This article was originally published December 18, 2020 on PSQH by Marcie Metroyanis, DNP, RN, NEA-BC, Patricia Reagan Webster, PhD, CPPS, and Robert Panzer, MD Abstract Background: Medical errors are the third leading cause of death in the United States (Makary & Daniel, 2016). Situational awareness, monitoring, and remediating risks in the clinical setting are hallmarks of the high reliability necessary to prevent patient harm. Design: To enhance awareness of hazards of medical errors that jeopardize the safety of patients, we created a “Medical Mayhem Room” to simulate safety risks that may be found in the patient care environment. Scenarios for each simulated patient included diagnosis, age, allergies, and precautions or special considerations. We deliberately introduced mistakes and hazards into each of these scenarios. The Medical Mayhem Room staged four patients with a total of 95 patient safety risk factors.