I was there, just not always where i needed to be. With new money an members. And its using controversial new tactics like an ad opposing the is she alright . I hope so. So i talked to my doctor about humira. Kavanaugh nomination. I learned humira is for people who still have symptoms its former director isnt pleased. Of Crohns Disease after trying other medications. For the a. C. L. U. Of all and the majority of people on humira organizations to be complicit in saw significant symptom relief and many achieved remission converting accusations into in as little as 4 weeks. Convictions without a trial. Humira can lower your ability to fight infections, including tuberculosis. Serious, sometimes fatal infections and cancers, im excited. Including lymphoma, have happened; as have blood, liver, we have been following a cutting edge Clinical Trial at and nervous system problems, serious allergic reactions, the National Institutes of and new or worsening heart failure. Health using gene therapy on a before treatment, get tested for tb. Brutally painful disease, tell your doctor if youve been to areas sicklecell anemia. Youll hear the surprising where certain fungal infections are common, results that one day may lead to and if youve had tb, hepatitis b, cures for thousands of other are prone to infections, or have flulike symptoms or sores. Diseases. To see that emerging not just dont start humira if you have an infection. As hoped for advances for, but real data showing cures for people. You is just cuesed the curing word. Youre willing to say that . This looks like a cure. Im steve kroft. Im lesley stahl. Im scott pelley. Im anderson cooper. Im jon lapook. Im bill whittaker. Those stories tonight on 60 minutes. I can do more to lower my a1c. Because my body can still make its own insulin. To activate my body to release it,licity onca like its supposed to. Trulicity is not insulin. It starts acting in my body from the first dose and continues to work when i need it, 24 7. Trulicity is an injection to improve blood sugar in adults with type 2 diabetes stahl the american civil when used with diet and exercise. Liberties union the a. C. L. U. Dont use it as the first medicine to treat diabetes, has been a thorn in the side of government for the nearly 100 or if you have type 1 diabetes years, since it was created. Or diabetic ketoacidosis. Dont take trulicity if you or your family with its unflinching devotion to the bill of rights, it has have medullary thyroid cancer, youre allergic to trulicity, angered just about everyone by or have multiple endocrine neoplasia syndrome type 2. Representing violent criminals, communists, and famously, in stop trulicity and call your doctor right away skokie, illinois, neonazis if you have symptoms of a serious allergic reaction, always insisting that if rights or severe stomach pain. Dont apply to everyone, they serious side effects may include pancreatitis. Apply to no one. A. C. L. U. Lawsuits and friend of taking trulicity with a sulfonylurea or insulin the court briefs have won huge increases your low blood sugar risk. Expansions of rights in this common side effects include nausea, diarrhea, vomiting, country miranda warnings from abdominal pain, and decreased appetite. Police, access to contraception, these can lead to dehydration, internet privacy, interracial which may worsen kidney problems. And samesex marriage. I choose onceweekly trulicity to activate my within. And yet, the a. C. L. U. Has always if you need help lowering your a1c, been something of a pariah ask your doctor about onceweekly trulicity. Being called a cardcarrying member suggests being to the left of the left. Thanksmrs. Murphy. Unitedhealthcare, hi, i need help getting an appointment with my podiatrist. But in the trump era, that thorn in the side of power has found hows wednesday at 2 . New power, and youll be i csday a10 . Agility. Surprised at the direction its taking. Aclu we are here; we stand with you m how about the 28th at 3 . Aclu stahl january 28, 2017. Donald trump had been president for a week and a day when the itasier get thearhen ed idulins a. C. L. U. Scored its first legal victory against him thank you, a. C. L. U. Lawyers stahl they won a temporary injunction against the seresto, serjake. Eresto. President s order banning seresto, seresto, seresto. Travelers from seven majority whatever your dog brings home to you, muslim countries, the night it shouldnt be fleas and ticks. After he signed it. Seresto gives your dog 8 continuous months a. C. L. U. Executive director Anthony Romero looked a bit of flea and tick protection stunned by the crowd. In an easytouse, nongreasy collar. Anthony romero ive come out seresto, seresto, seresto. Of many courthouses. I have never come out of a courthouse where there were ohh no, jake. 3,000 people who spontaneously seresto. Amassed. 8month. Seresto, seresto, seresto. So, we want to thank you, very, very much. Cheeri stahl am i correct that soon thereafter you started to see bumps in your membership . [indistinct conversation] romero there were almost 400,000 new members just on that one weekend, after the muslim ban. Trump we are also taking strong measures to protect our nation. [friend] ive never seen that before. Stahl at President Trumps first address to congress, some senators and congressmen wore blue a. C. L. U. Ribbons, that also turned up on hollywood red i have. Romero that was new. Stahl that was definitely new. Romero yeah. David cole what we saw after President Trump was elected was the most energized citizenry around Civil Liberties and civil rights that i have ever seen. Stahl david cole is the a. C. L. U. s National Legal director. Cole we had all these people coming to us, newly joining the a. C. L. U. And wanting to engage. Not wanting just to write a check or push a button, but wanting to actually take action in defense of liberty. Stahl you owe it all to donald trump. Cole exactly. He has reminded people of the importance of standing up and defending liberty. Stahl the a. C. L. U. Senior staff saw membership nearly quadruple, and online donations came pouring in. How much . Pelley fridays surprisingly romero over 120 million in the first year. Weak job creation numbers wereas stahl what . 120 million in the first year slowing. After trump was elected . Economists and the president will debate whether the federal that was 25 times the previous reserve is the reason. Years number. Did you think that was going to the chair of the Federal Reserve happen . Romero never. Is arguably the most powerful lawyer we have won every person handling our economy. Single one of those motions. But, interviews with the head of the fed are rare. Money to wor hirin chairman Jerome Powell was and filing lawsuit after lawsuit appointed to the board of against the administration governors by president obama and 115 of them, so far. Was elevated last year to chairman by President Trump. Cole so we sued him over the since then, the fed has raised muslim ban. Weve sued him over family separation. Interest rates four times, we sued him over the adding leading mr. Trump to call the Citizenship Question to the Federal Reserve crazy. Census. Last week, at the feds stahl are you busier than headquarters in washington, we youve ever been against an administration . Asked powell about interest cole i think without rates, whether the president can question. Fire him, and what he believes faiz shakir one, two, three are the greatest threats to people power prosperity. Stahl but the a. C. L. U. Did have you stopped raising rates . More than file lawsuits. Jerome powell well, thats a good question. It set out to turn all those we see the economy as in a good place. People wanting to take action we t tfaon into a grassroots civil inflation is muted, and our liberties army called people policy rate, we think, is in an power, modeled after a group appropriate place. So what weve said is that we would be patient. That might seem an unlikely pelley what does patient mean . Source of inspiration for the powell patient means that we a. C. L. U. The n. R. A. , the dont feel any hurry to change National Rifle association. Our Interest Rate policy. Youre looking to the n. R. A. For what whats happened in the guidance . laughs last 90 or so days is that weve romero yeah. Stahl come on. Seen increasing evidence of the the a. C. L. U. And the n. R. A. . Global economy slowing down, romero were very different. Although our own economy has continued to perform well. Stahl no kidding. Romero we believe in the regulation of firearms. Pelley where do you see they focus on one amendment. Weakness in the u. S. Economy . Ive got the rest of them. But theres a lot we can learn powell generally speaking, from them. The u. S. Economy is coming off a very strong year last year. Stahl as a. C. L. U. Political we had growth, just a touch director, faiz shakir has been higher than 3 . In charge of implementing some we have high levels of employment, low levels of of the n. R. A. s lessons. Unemployment, wages are moving up. What is it in their model that Consumer Confidence is high, you like . Business confidence is high. Shakir theyre building Civic Society around their weve seen a bit of a slowing, issue. You go to gun clubs and gun but i would say the principal shows, even p. T. A. Meetings and risks to our economy now seem to church meetings, with your be coming from Slower Growth in fellow activists. And i think that is china and europe, and also risk events, such as brexit. Inspirational in some regards for us, to think about pelley a record seven mobilizing your issues as a as million amanhale a lifestyle. Behind on their car payments. Stahl and, as the deciding never happened before. Factor at the ballot box. What do you make of that . Just as the n. R. A. Built a bloc powell car sales have been quite high for a number of of gun rights voters, theanloc c years. So, the whole body of outstanding auto loans is much larger than it was. Rights a voters. I think it also, though, shows that not everyone is their slogan vote like your experiencing this widespread rights depend on it. Prosperity that we have. But theyre not taking and thats something we pay everything from the n. R. A. Attention to as well. Playbook. Romero what is different is pelley retail sales declined in december, the fastest pace that we dont pick a candidate. Since 2009. We dont give money to a candidate. Are these things, taken we dont have a pac. Together, suggesting that the stahl thats because the a. C. L. U. Has a strict and long system is blinking red . Powell theres also standing policy of non evidence, by the way, that partisanship never supporting spending has popped back up in january. A political party, and never but well thats a endorsing or opposing any surprisingly weak reading, and candidate for elective office. Well be watching the next months reading shortly. The idea is to remain free to pelley but the overarching challenge anyone in government question is, are we headed to a recession . Whose actions violate Civil Liberties. Powell i think growth this year will be slower than last were calling about amendment four. Year. Last year was the highest growth stahl so, as the a. C. L. U. That weve experienced since the dove into the fall midterm financial crisis, really in more than ten years. Elections with more funds and fight than ever. This year, i expect that growth, continuebele federal res cagned forlot system was createdco aia initiatives in several states to expand Voting Rights, a longtime a. C. L. U. Goal. S mission is to create mimum shakir i want to move to races real quick. Stahl but shakirs team also employment, while keeping inflation under control. Got involved in two governors you mentioned growth last year being slightly over 3 . Races, leading to complaints they violated their own policies. That was with the tax cut, and with unemployment in this in kansas, thensecretary of country at a rate that we state kris kobach, a president havent seen in decades. Trump ally who the a. C. L. U. Had is that the best the economy can sued several times, alleging do now . Voter suppression, was in a are the days of 4 growth over . Tight fiveway race for governor. Powell you can break it down kris kobach took an oath to into a couple of things. Uphold the constitution, and one is, how fast is the labor force growing . Then, as secretary of state, he and the other part is, how fast was held in contempt of court is productivity growing . For refusing. Stahl the a. C. L. U. Ran tv the labor force, back when we used to have 4 and 5 growth ads and sent mailers critical of kobachs record. Years, the labor force was growing quickly, 2. 5 , 3 in. Threatening children with disabilities. Some cases, back in the 60s and 70s. Regardless of who you vote for we have an older population now, on november 6, we the people and our labor force is growingy. Must demand that politicians respect the rule of law. The a. C. L. U. Does not endorse or oppose candidates. Sustain the kinds of growth stahl heres what i smile rates that we had when at. Shakir yes. Population and the labor force stahl you have that ad. Was growing more quickly. You tell the voters of kansas pelley so 4 is something we all the things that you strongly shouldnt expect in the future . Disagree with about him. Powell there will be years of 4 growth. And then at the bottom it says, but it would be. It would be we dont endorse candidates. Shakir yes, thats right. Challenging to see sustained 4 growth, again, because of the we are also advertising to slow growth of the workforce. People that we are a nonpartisan organization, that we dont endorse and oppose candidates. So when you watch an issue pelley powells experience stahl its like a wink thing. In the workforce is a privileged ha, ha, we dont endorse shakir i dont think it is a one. Wink thing. Princeton led to georgetown law, it was the most horrific day which led to a wall street of my life. Hl in geo addicted to drugs. Career that made him a multi millionaire. Now, as chairman, hes been governors race, the a. C. L. U. Ran an ad touting democrat raising rates in tiny increments to control inflation. Stacey abrams record on but the president thinks hes criminal justice. Gone too far. And Stacey Abrams will end trump no, i think the fed is dependence on private prisons, saving millions that could instead be used for treatment. Making a mistake. Theyre so tight. We were so destroyed as a family. I think the fed has gone crazy. A. C. L. U. Does not endorse or oppose candidates. Powell i dont think it would be appropriate for me to ira glasser they ran an ad comment on other elected which you could show to 1,000 officials, or on the president. People, and 1,000 people would say, if you asked them, oh, pelley isnt it your duty to thats a political ad for stacey respond, when the president abrams. Calls the fed a much bigger stahl ira glasser spent problem than china . Powell my duty is one that 34 years at the a. C. L. U. 23 of congress has given us, which is them as executive director. To use our tools to achieve maximum employment and stable he believes the a. C. L. U. s prices, and to supervise and involvement in candidate races regulate banks so that they haos treat their customers fairly and partisanship, and hes concerned enough about it to so that theyre strong, wellpim speak out. Their critical function in good glasser i think its strategically weakening its times and bad. Thats my job. Mission. Pelley can the president fire you . The best strategy of protecting powell well, the law is Civil Liberties is not to be partisan. Clear that i have a fouryear stahl the current leadership term. And i fully intend to serve it. Of the a. C. L. U. Would say, what pelley so no, in your view . Powell no. Theyre really doing is just pelley how independent is the fed . Telling you where Stacey Abrams stands on issues, and where her who do you answer to . Opponent glasser no, but thats not what theyre doing. Powell we are directed to theres nobody could look at take, to execute policy, in a that ad and not think it was a campaign ad for Stacey Abrams. Strictly nonpolitical way, it was. Serving all americans, and thats what we do. Look, we are living in a time we are independent, in that now where trump has made it a sense. Our decisions on rates cant be cultural habit to say to do reversed by any other part of government. Something and then, while youre doing it, deny that youre doing our accountability runs through it. So the fact that they deny it is mmtees ined representatives and just dissembling, its just ress. Its just, you know dishonest. Pelley traditionally, chairs of the fed dont do interviews. Stahl ira glasser says that their words can upend markets. Ky this is a key principle of the a. C. L. U. , not to get involved with candidates. Ben bernanke on 60 minutes he thinks you crossed a line. During the great recession. Cole hes welcome to his views, and well defend hist tod recently, we assembled bernanke, his successor, janet yellen, and powell. And i wonder what kind of advice youve given chairman powell whether the government is going about the withering criticism that you might get from the to respect Civil Liberties or public, congress, business, the violate Civil Liberties. President . Ben bernanke well, i kept and so why would you not ask the on my desk a quotation from Abraham Lincoln to the effect citizenry to think about that issue when they are choosing who that, if youre right, it wont matter what they say. They want in office . If youre wrong, it wont matter what they say. Romero it would be almost so the best thing to do is to malpractice if, in this moment, make what you believe is the right call. We said, oh, were not going to pelley chair yellen, what advice did you give to chairman engage the political process powell . Janet yellen we worked because were afraid of being called partisan. Together closely, and i knew when our issues are at play, that he knew everything that one like immigrants rights, and Voting Rights, and reproductive needs to be a successful chair rights, and l. G. B. T. Rights, we to be inclusive in decision have an affirmative obligation to step up. Making, to bring many voices to the table, to listen carefully. Stahl but glasser says powell being in this role is theyre stepping up too much, a very humbling thing. Putting progressive politics and you learn to listen to other aheaieconcerns like the peoples perspectives pretty well. Presumption of innocence. Pelley powell listens to a lot of perspective in the feds boardroom. Case in point the a. C. L. U. s the federal open market decision to oppose brett Committee SetsInterest Rates. Kavanaughs Supreme Court nomination. Christine blasey ford youve had four Interest Rate i believed he was going to increases in your tenure. Rape me. Stahl . Based on christine i wonder, were any of those blasey fords allegation of unanimous . Sexual assault and kavanaughs response. Powell they were all unanimous. Pelley all four . The a. C. L. U. Bussed and flew in powell thats not to say that we dont have vigorous discussions, and a range of large numbers of women to perspectives. Capitol hill to lobby key pelley the fed wants to senators and ran an ad in four maintain inflation at 2 , about where it is now. States, insinuating kavanaughs but powell told us hes guilt by association. Flexible to a point. Weve seen this before, if the inflation rate rises denials from powerful men. Clinton i did not have something over 2 for a limited period of time, that doesnt sexual relations with that woman. Mean the feds going to jump on the brakes . Powell i think we wouldnt cosby ive never seen anything like this. Kavanaugh i categorically overreact to inflation modestly and unequivocally deny the allegation against me by dr. Above 2 any more than we ford. Overreacted to inflation america is watching. Modestly below 2 . Oppose the confirmation of i think well always be moving judge kavanaugh. Stahl weve heard criticism inflation back to 2 with our policy. That the a. C. L. U. Would oppose but i think we do that in a someone on an unproven charge. Pelley its taken nearly a decade to worry about inflation youre usually defendieople again. When theres an unproven charge. The collapse in the 2008 cole right. Financial crisis was the worst and if the question was whether since the great depression. Brett kavanaugh should go to mortgage fraud on a massive jail, we would have defended him. But the question was not whether he should go to jail. Scale caused the dow to fall 54 the question was whether he should be appointed to one of and unemployment to rise to 10 . The most powerful positions in taxpayers were force government, for life. Stahl this wasnt a criminal out reckless wall street excess. Trial. It wasnt even a civil trial. It was a Job Interview. Back then, tighter restrictions glasser i agree with the were imposed on banks. Fact that it was a Job Interview and not a criminal trial, but but now, powell and congress are loosening those rules. Were talking about the a. C. L. U. Are american banks safe today . Taking out a Million Dollars worth of ads, arguing that an powell the American Banking accusation was the equivalent of system is much, much stronger a finding of guilt. And more resilient than it was for the a. C. L. U. , of all before the financial crisis. Organizations, to be complicit particularly the largest banks in in the National Pastime now have double or more the amount of converting accusations into of capital, which is to say, convictions without a trial resources to absorb losses. In addition, weve required them stahl ira glasser, who had to undergo resolution planning your job for many years. Romero a great director. O, which doesnvolve a taxpay stahl he has said that the bailout. Changes that have come about pelley but in 2007, the fed recently under your leadership are shortsighted, and may missed the reckless, criminal undermine the credibility of banking that was happening. This organization. Romero i think he gets it how do you know today that the wrong. Were more relevant now than banks are safe . Weve ever been. Powell we spent ten years were more impactful than weve ever been. I think thats a sign of our analyzing, understanding what success, that we are willing to went wrong, and trying to correct it. Take kind of on new tactics and new strategies, even as we pelley a collapse of the remain true to the Core Financial system like we saw in principles. 2008 cannot happen again . Shakir yeah, look at that cheers stahl on Election Night in powell cannot is a strong statement. November, all the Voting Rights measures the a. C. L. U. Fought for passed. You know, i would say that our cheers system is vastly more resilient. And in kansas, kris kobach was pelley how concerned are you defeated. But, victory didnt silence the about either criminals, or more criticism. Importantly, hostile nations, three a. C. L. U. State affiliates attacking our Banking System have gone on record opposing through the Computer System . What one called the abandonment powell we devote very large of nonpartisanship, and amounts of time and resources to turning the a. C. L. U. Into an protect the fed, but also to advocacy organization. Do you see yourself now as a protect Financial Institutions critic of the a. C. L. U. . And the financial markets. Glasser no, i see myself as the banks we supervise are a critic of some of what the required to have plans in place a. C. L. U. Is doing. The a. C. L. U. Probably still does and state of the art, you , more good work on issues i care about than any organization in america. The sacred importance of their primary mission, and theres i just hit on the thing that keeps you up at night. Nobody else to do it. Powell i would say, of the risks that we face, that certainly is the largest one. Stahl political director pelley its become your top priority. Faiz shakir recently announced powell the kinds of risks his departure from the a. C. L. U. That we faced in the financial his new job Bernie Sanders crisis are very real, but we campaign manager. Know, i think, generally what to do there. Cyber is a relatively new kind of a risk with nation state actors, and its one where the playbook is still being developed in real time. Welcome to cbs sports hq presented by progressive insurance. Im greg gumbel in new york. Pelley powell told us about one week from selection sunday, another risk, hidden in our economy. And the field of 68 is beginning to fill up. It includes an estimated half a earlier today on cbs in college million workers whove given up basketball, bradley overcame an 18point secondhalf deficit to looking for jobs. Win the Missouri Valley powell we have an unusually conference title. Gardnerwebb is going to their large number of people in their first ncaa tournament after prime working years who are not winning the big south in the labor force. Championship. The United States has a lower and in the atlantic sun, liberty knocked of Labor Force Participation rate than almost every other advanced tournament ticket since 2013. Country. That is not our selfimage as a country. M. Pelley where did these people go, who are no longer im not calling him dad. Looking for work . Oh, nno. Powell part of it is look, [sighs] i get it. Evolving technolog some new guy comes in helping your mom bundle and save with progressive, requires rising skills on the part of the people. But hey, were all in this together. U. S. Educational attainment has right, champ . Not moved up as rapidly as it im getting more nuggets. Has in other countries. How about some carrots . Globalizations also a factor. You dont want to ruin your dinner. Youre not my dad for many advanced economies, thats fair. Manufacturing to some extent, overstepped. Has moved into developing countries. So for whatever reason, and the Opioid Crisis is related to, i think, to those other factors. Pelley the Opioid Crisis . Powell the Opioid Crisis is millions of people. They tend to be young males. And its a very significant problem. And its part of a larger picture. Pelley you seem to be talking about part of this generation being lost. Powell that is the issue. When you have people who are not taking part in the Economic Life but when i started seeing things, of a country in a meaningful i didnt know what was happening. Way, who dont have the skills so i kept it in. He started believing things that werent true. And aptitudes to play a role, or who are not doing so because of i knew something was wrong. Because theyre addicted to but i didnt say a word. Drugs, or in jail, then in a during the course of their disease sense, they are being left around 50 of people with parkinsons behind. May experience hallucinations or delusions. Pelley still, these are not bad days to be chair of the fed. But now, doctors are prescribing nuplazid. Unemployment is near a 50year the only fda approved medicine. Low, wages are growing at a pace proven to significantly reduce of more than 3 , and if the hallucinations and delusions expansion lasts another three related to parkinsons. Dont take nuplazid if you are allergic to its ingredients. Months, it will be the longest nuplazid can increase the risk of death in history at ten years. In elderly people with dementiarelated psychosis how long can it last . And is not for treating symptoms powell i would just say, unrelated to parkinsons disease. Theres no reason why it cant continue. Nuplazid can cause changes in heart rhythm pelley for years . Powell eventually, and should not be taken if you have certain expansions come to an end. Abnormal heart rhythms or take other drugs the Business Cycle has not been repealed. That are known to cause changes in heart rhythm. But i would say theres no reason why this economy cannot tell your doctor about any changes in medicines youre taking. Continue to expand. The most common side effects are swelling of the arms and legs and confusion. We spoke up and it made all the difference. Ask your parkinsons specialist about nuplazid. Cbs money watch sponsored by the capital one saver card. Whats in your wallet . Morhave discoveredour their irish roots. Good evening. Which means your smiling eyes, might be irish too. A boeing Technical Team is headed to ethiopia after the order ancestrydna, deadly crash of a new 7378 max and find the surprises in you. Just 59 through march 18th. Jetliner. President trumps budget get your kit today. Tomorrow is expected to boost military spending and cut domestic priorities. And the longest bull market in history begins its 11th year monday. Im elaine quijano, cbs news. Tto harrison, the wine tcollection. To craig, this rock. The redwoods to the redheads. The rainbows to the proud. I leave these things to my heirs, all 39 million of you, on one condition. That you do everything in your power to preserve and protect them. With love, california. Dearest britain. We love you. Maybe its your big hearts. Your sense of style. Welcome to ba100. ba100, youre clear for takeoff . How you follow your own path. Youve led revolutions. Of all kinds. Yet you wont shout about it. Its just not in your nature. Instead, youll quietly make history. Cake. Beds. Poetry. Trouble. Love hope and rather a lot of tea. The best of britain, from the moment you step on board. Lapook nearly 20 years ago, scientists stunned the world when they announced they had decoded the genes that make up a human being. They hoped to use that genetic blueprint to advance something called gene therapy, which locates and fixes the genes responsible for different diseases. Now, a Clinical Trial at the National Institutes of health is doing exactly that in an attempt to cure sickle cell anemia a devastating genetic disease that kills hundreds of thousands of people around the world every year. For the past 15 months, weve been following the scientists, and patients, who are ushering in a genetic revolution. Jennelle stephenson im excited. Tephenoday ithe big day. Lapook its the day after christmas, 2017, and 27yearold Jennelle Stephenson has come with her father and brother from ida nio institutes of health, just outside washington, d. C. Jennelle stephenson good morning. Dr. John tisdale good morning. Lapook shes one of a small group of patients to receive an infusion containing altered d. N. A. Nurse this is what they look like. Jennelle stephenson Merry Christmas to me. Brother best Christmas Present ever. Jennelle stephenson yay. Lapook the clear liquid in the bag contains jennelles stem cells, that have been genetically modified. Dr. Tisdale there are about 500 million in there. Jennelle stephenson oh, my goodness. Lapook the hope is the new d. N. A. In the cells will cure jennelle of sickle cell anemia a brutal disease that causes debilitating pain. At its worst, on a scale of zero to ten, how bad was your pain . Jennelle stephenson we can go beyond a ten. Its terrible, its horrible. Lapook pain where . Jennelle stephenson everywhere. My back, my shoulders, elbows, arms, legs, even my cheekbones, just pain. Lapook can you actually describe it . s aleeike bonerushing releasistantl lapook pain from sickle cell can occur anywhere blood circulates. Thats because red blood cells, normally donutshaped, bend into an inflexible sickle shape, causing them to pile up inside blood vessels. The resulting traffic jam prevents the normal delivery of oxygen throughout the body, leading to problems that include bone deterioration, strokes and organ failure. The gene that causes sickle cell anemia evolved in places like subsaharan africa, because it protects people from malaria. There, millions have the disease, and its estimated more than 50 of babies born with it die before the age of five. Dr. Glassberg right on the bone there . It affects 100,000 people mostly african americans. For jennelle, having the disease as a child often meant spending christmas in the hospital. As an adult, she struggled through pain to complete college, but keeping a job was tough because something as simple as walking up stairs could trigger a pain crisis. Do you have friends whove died from sickle cell . Jennelle stephenson i do. Yes, younger than me. Lapook and youve known this your whole life growing up . Jennelle stephenson right. Lapook that you could potentially die early . Jennelle stephenson right. Yes. Lapook did you think you would die early . Jennelle stephenson i did, actually. When i hit about 22, i was like, you know, im for a sickle celler, im kind of middleaged right now. Lapook what are some of the things that youve always wanted to do that you couldnt do . Jennelle stephenson honestly, everybody laughs at me for this i just want to run, to be honest. Lapook things that most people would take for granted. Jennelle stephenson just basic things. Lapook one of the most cruel parts of the disease, jennelleh, is being accused of faking pain to get narcotics, being labeled a drugseeker. During one trip to the emergency department, when she fell to the floor in pain, a doctor refused to help her. Jennelle stephenson and im looking up at her, and im in tears, and, im like, im doing the best that i can. Lapook and youve got to be thinking. Jennelle stephenson i just, sometimes i dont understand, i dont get it. Like, sorry. Im in so much pain, and you think i just want some morphine. And it just makes me sad that some people in the medical Community Just dont get it. Dr. Francis collins so this would be my lab. Lapook dr. Francis collins is director of the National Institutes of health, the largest Biomedical Research he oversees budget that funds more than 400,000 researchers worldwide. Clinton dr. Collins, please come up to the lectern. The n. I. H. In 2000 when he made a landmark announcement after a decade of work, scientists had finally decoded the genes that make up a human being. Dr. Collins today, we celebrate the revelation of the first draft of the human book of life. Lapook when did it all start for you . Dr. Collins i got excited about genetics as a firstyear medical student. A pediatric geneticist came to teach us about how genetics was relevant to medicine. And he brought patients to class, and one of the first patients he brought was a young man with Sickle Cell Disease who talked about the experience of sickle cell crises and how incredibly painful those are. And yet, it was all because of one single letter in the d. N. A. That is misplaced, a t that should have been an a. And that was profound. You could have all of that happen because of one letter that was misspelled. Lapook the double helix of d. N. A. Is made up of billions of pieces of genetic information. What dr. Collins is saying is. Out of all that, its just one error in the d. N. A. Code a t that should have been an a that causes sickle cell anemia. Fix that error, and you cure the disease. But figuring out how to do that would take more than 20 years of research. Do you remember when we used to sing lapook . And a little serendipity. Dr. Collins was playing in the n. I. H. Rock band in 2016 when his bass player hematologist dr. John tisdale started riffing on an idea. Dr. Tisdale wed finished setting up and went for a pizza, before dr. Collins i remember that. Dr. Tisdale before the gig. And at this point, i pitched to th wdo something definitive for Sickle Cell Disease. Lapook in dr. Tisdale and his collaborators created a gene with the correct spelling. Then, to get that gene into the patient, they used something with a frightening reputation h. I. V. , the virus that causes aids. It turns out, h. I. V. Is especially good at transferring d. N. A. Into cells. Dr. Tisdale so this shows the process. Lapook heres how it works. The corrected gene, seen here in yellow, is inserted into the h. I. V. Virus. Then, bone marrow stem cells are taken from of a patient with sickle cell anemia. In the laboratory, those cells are combined with the virus carrying that new d. N. A. Dr. Tisdale this virus will then find its way to one of those cells and drop off a copy or two of the correctlyspelled gene. And then, these cells will go back to the patient. Lapook if the process works, the stem cells with the correct d. N. A. Will start producing healthy red blood cells. I capl s out there, thinking, wait a second, how do you know youre not going to get aids from the h. I. V. Virus . Dr. Tisdale the short answer is, we cut out the bits that cause infection in h. I. V. And we really replace that with the gene thats misspelled in Sickle Cell Disease, so that it transfers that instead of the infectious part. Lapook the stakes here are enormous. Dr. Collins yes. Lapook theres really very little safety net here, right . Dr. Collins make no mistake, were talking about very cuttingedge research, where the certainty about all the outcomes is not entirely there. We can look back at the history of gene therapy and see there have been some tragedies. Lapook deaths . Dr. Collins yes. Lapook in 1999, 18yearold Jesse Gelsinger received altered d. N. A. To treat a different genetic disease. He died four days later, from a massive immune response. And in another trial, two children developed cancer. Jennelle stephenson understands this is a trial, with huge risks, and no guarantees. Jennelle stephenson this is it. Lapook when she arrived at the n. I. H. Clinical center in december 2017, jennelle asked her brother, ray, for some help. Jennelle stephenson there goes ray, cutting my hair. Oh, snip. Lapook she decided to cut off all her hair, rather than watch it fall out from the massive dose of chemotherapy needed to suppress her immune system so her body wouldnt reject the altered stem cells. Jennelle stephenson i dont know how to feel right now. Im a little emotional. But im okay; it will grow back. Lapook a few days after the chemotherapy, jennelle received the infusion of genetically modified cells. Dr. Tisdale is it going good now . Nurse yes. Jennelle stephenson its just a waiting game. Lapook but the wait was a painful one. Not only for jennelle, but also for her father, ray. Ray stephenson let me fix this heating pad a little bit. Lapook . Who did what little he could as the effects of the chemotherapy kicked in, stripping jennelles throat and stomach of their protective layers. Jennelle stephenson oh, that hurts. Lapook she was unable to speak for a week, and lost 15 pounds. And, because having a severely weakened immune system means even a mild cold can turn deadly, jennelle had to stay in the hospital for nearly a month. Last spring, she moved back to florida and returned to the n. I. H. For periodic checkups. Dr. Tisdale these are her red blood cells. Lapook it didnt take long for dr. Tisdale to notice something was happening. This is jennelle before any treatment . Dr. Tisdale right. All across her blood you can see these really abnormal shapes. This one in particular is shaped like a sickle. Lapook nine months later, this is what dr. Tisdale saw not a sickle cell in sight. Was there ever a moment where you saw one of these normal looking smears and thought, is this the right patient . Dr. Tisdale oh, absolutely. E skeptical all the time. So, first thing you do is look and make sure its that patient, go grab another one, make sure its the same. And weve done all that. And, indeed, her blood looks normal. Teacher move. Switch your arms and move. Lapook remember, jennelle used to struggle just to walk up a flight of stairs. Teacher and you fall. Lapook . And a fall like this would have landed her in the hospital. Teacher boom. Yeah. Good job. You did it. Bam. Lapook jennelle. You look amazing. Jennelle stephenson thank you. Lapook i have to say, i was a little nervous when you were thrown and you went down on the mat. Jennelle stephenson it was nothing. It was nothing. My body just felt strong. Lapook tell me about the adjustment that you need to make, to go from the old you to the new you. Jennelle stephenson my body, it almost felt like it was, like, itching to do more. And i was like, all right, well, lets go swimming today. Lets go to the gym today. Im like, all right, my body loves this. I kind of like it because my, i guess, all my endorphins started pumping. Lapook the endorphin high, something you had never experienced. Jennelle stephenson never experienced before. Yup. Lapook what was going through your head as you were thank you for medical science. And thank you for giving her a new life. Jennelle stephenson new life, indeed. Lynndrick holmes ive never lived before. Lapook eight other adults with sickle cell anemia have undergone the same gene therapy as jennelle. So far, all are responding well. Dr. Francis collins says it will take years to improve the treatment to make it more widely available. Dr. Collins heres another dream. There are 7,000 genetic diseases for which we know the precise d. N. A. Misspelling. Couldnt this same strategy, this same set of principles work for lots of those, maybe someday all of them . Lapook youve been working on this for decades. Youre at a moment which is significant. Dr. Collins to lead the human genome project and to put that foundation in place. And now, to but real data showing cures for people. Lapook you just used the curing word. Youre willing to say that . Dr. Collins i believe that this looks like a cure. Ive got to be careful. But from every angle that i know how to size this up, this looks like a cure. To learn more about the nih trial that may have secured janelle and dr. Jon lapooks thought on genetic therapy, go to 60minutesovertime. Com, sponsored by pfizer. Cold turkey. Ng soprhe you quit. Elp you quit slow turkey. G , is with chantix you can keep smoking at first and ease into quitting. Chyoull be more ready to kissen cigarettes goodbye. When you try to quit smoking, with or without chantix. You may have nicotine withdrawal symptoms. Stop chantix and get help right away if you have changes in. Behavior or thinking, aggression, hostility, depressed mood, suicidal thoughts or actions, seizures, new or worse heart or blood vessel problems, sleepwalking, or life threatening allergic and skin reactions. Decrease alcohol use. Use caution driving or operating machinery. Tell your doctor if youve had Mental Health problems. The most common side effect is nausea. Quit smoking slow turkey. Talk to your doctor about chantix. Its easy to move forward when youre ready for what comes next. At fidelity, we make sure you have a clear plan to cover the essentials in retirement, to keep you on the right track, without the unnecessary fees you might expect from so many financial firms. Because when you have a partner who gives you clarity at every step, theres nothing to stop you from moving forward. Who gives you clarity at every step, actually, thats my buick. Your buick doesnt have a roof rack this is my buick. How are we gonna fit in your moms buick . Easy. I like that new buick. Me too. I was actually talking about that buick. I knew that. Did you . Buicks fresh new lineup is full of surprises. Its march madness. Get a sweet 16 below msrp on most of these buick models. Ooh woo, im a rebel just for kicks, now i been feeling it since 1966, now might be over now, but i feel it still ooh woo, im a rebel just for kicks, now ooh woo, im a rebel just for kicks, now let me kick it like its 1986, now might be over now, but i feel it still mightve had your fill, but you feel it still, ooh woo pelley im scott pelley. Well be back next week with another edition of 60 minutes. But some give their clients cookie cutter portfolios. Fisher investments tailors portfolios to your goals and needs. Some only call when they have something to sell. Fisher calls regularly so you stay informed. And while some advisors are happy to earn commissions whether you do well or not. Fisher investments fees are structured so we do better when you do better. Maybe thats why most of our clients come from other money managers. Fisher investments. Clearly better money management. To severe Rheumatoid Arthritis was intense. My moms pain from moderate i wondered if she could do. Which is kind of, a lot. And if that pain. Could mean something worse . Joint pain could mean joint damage. Br. And helps stop irreversible joint damage. Enbrel may lower your ability to fight infections. Serious, sometimes fatal events including. Infections, tuberculosis, lymphoma, other cancers, nervous system, and blood disorders, and allergic reactions have occurred. Tell your doctor if youve been some place where fungal infections are common. Or if youre prone to infections, have cuts or sores, have had hepatitis b, have been treated for heart failure, or if you have persistent fever, bruising, bleeding, or paleness. Dont start enbrel if you have an infection like the flu. Since enbrel. My moms back to being. My mom. Visit enbrel. Com. And use the joint damage simulator to see how joint damage could progress. Ask about embrel. Enbrel. Com fda approved for over 19 years. Captioning nded by cbs and ford. We go further, so you can. Captioned by Media Access Group at wgbh access. Wgbh. Org previously on god friended me. Simon hayes. Pleasure to meet you, man. Im working on something pretty revolutionary. Why would henry run the god account through simons servers . Because its henrys way of making a point. Arthurs tenure here at harlem episcopal might be coming to an end, and we think you would make an excellent replacement. Will you go to dinner with me . Id love to. [gentle music] wow. [wave romes be my girl] clouds looking down gits our i touchtoould we would never know its making me crazy its a nice night