Hit as a category 3. Mandatory evacuations, multiple states in the path of This system. Ginger zee with the latest track. Also breaking as we come on, the images coming in now, a toxic and flammable Chemical Leaking Outside Cincinnati. Thousands evacuating, authorities moments ago saying they are concerned over the potential for an explosion now. Many being urged to close doorms and windows, and to seal them, if you can. With President Biden before World Leaders at the u. N. Today, tonight, israel launching a new wave of deadly Air Strikes on beirut. The israeli military saying a top Hezbollah Commander was killed in a targeted missile attack. Tens of thousands of people trying to escape. What the president said about the escalating crisis. Ian pannell In Beirut. Election day, 42 days away now. Donald Trump And Xkamala harris on the economy and on immigration. Former President Trump in georgia. Vice president harris headed to pennsylvania, and then to the border. Tonight, Football Hall of Famer Brett favres stunning reveal while on Capitol Hill. His very personal battle, his diagnosis. Overseas, an american woman is believed to be the first person to ever use whats called a Suicide Pod in switzerland. A criminal investigation now under Way Tonight. The 64yearold Woman from the midwest reportedly had suffered from an autoimmune condition. In Kansas City tonight, the daring rescue. 23 stories up. Also, 12 members of a University Lacrosse Team tonight seriously injured, several hospitalized after a workout conducted by a Navy S. E. A. L. What the workout included. The earth about to get a second mini moon. In new York City tonight, who Sean Diddy Combs is now sharing space with behind bars. The fireworks on Capitol Hill over the cost of those popular Weight Loss drugs. Why are they so expensive . How the ceo answered. And America Strong tonight. The grandmother hiking, she lost her footing. Who found her and rescued her on that trail . Its remarkable. Good evening. We begin tonight with two bre breaking stories. This toxic laeg. Thousands evacuating Outside Cincinnati at This hour. There is concern over the potential for an explosion now. The images coming in just moments ago. But first, bracing for what could become a category 3 hurricane. States of emergency already up tonight. Hurricane warnings and watches in florida and now georgia, as well. Tropical Storm Helene gaining strength at This hour and bearing down, expected to become a major category 3 hurricane, with 115mileanhour winds. Up to a foot of rain possible. A dangerous storm surge. And flooding well inland. Storm clouds gathering on the beaches of cancun, mexico, ahead of Helenes Arrival there. Expected to make landfall here in the u. S. On thursday. Tonight, mandatory evacuations already under way. Chief meteorologist Ginger Zee back with us tonight, leading us off with the latest track of This. Hi, ginger. Reporter hey, david. This storm should be a Hurricane By tomorrow. Once its in the gulf, it is going to rapidly intensify. Head toward the coast, make landfall thursday night. Somewhere in the Eastern Panhandle or the big bend of florida. Either way, major impacts well beyond that cone, and thats why we have widespread warnings including a warning from apalachicola to cedar key. Tampa bay is in that hurricane watch. Savannah, georgia, with a tropical storm watch. Lets talk about the number one loss of life and property, that is storm surge. Crystal river, 6 to 10 feet. Thats a lot of water. 4 to 8 feet around tampa bay, causes big problems. And then, talk about the wind and timing. So, the wind will start to pick up, especially thursday. Thursday night, when we see landfall. On This model, perry has a 1 120mileperhour gust. Then This thing cruises overnight, by 7 00 a. M. , its in western north carolina, with a 70mileperhour Gust at asheville. Not just the winds that will knock down Power Lines and trees, but that significant risk of flash flooding, greenville, south carolina, in there, too. David . David Ginger Zee, thank you. In the meantime, to the Emergency UnfoldingOutside Cincinnati, as i mentioned at This hour. The toxic and flammable Chemical Leak from a train in hoi hoip. Authorities just before we came on the Air Tonight saying they are now concerned over the potential for an explosion in the hours ahead. They are dousing the train. Thousands of families have been urged to leave the area. And residents who are staying have been told to stay indoors and to try to seal their windows if they can. Gio benitez with the images coming in now. Reporter tonight, the alarming scene. You can smell it. Reporter a train spewing a toxic Chemical Cloud into the air, sparking urgent evacuations in ohio. Firefighters racing to the scene near cleves, about 30 Minutes West of cincinnati, spraying water on the railcars. The company that owns the train saying one of its railcars was venting styrene, a colorless, flammable, and highly volatile liquid used to make plastics and rubber. Its nasty smelling. Reporter about 3,000 people near the scene urged to leave the area immediately. Schools put on lockdown and evacuated. Residents told to stay inside and seal off doors and windows. With the heat of the material in the car, that there is potential for an explosion. Reporter it comes more than a year after a devastating Train Derailment in east palestine, ohio, that caused Ah Ha sarr douse Chemical Fire to burn for days, leading to a massive cleanup. And david, of course, as you mentioned, Authorities Tonight are very concerned about a potential explosion. Thats why This is such a big deal. And as you can imagine, environmental agencies are responding right now to that scene, david. David gio benitez, thank you. Now, to the escalating war between israel and hezbollah, with President Biden before World Leaders at the u. N. Today. The crisis escalating overseas. Israel launching a new round of Air Strikes on lebanon, saying theyve now killed another top hezbollah leader. Hezbollah firing back, some rockets actually getting through Israels Iron Dome defenses. President Biden Today in his final u. N. Address as president calling for an end to the escalation, saying a diplomatic solution is still possible. Our chief foreign correspondent Ian PannellIn Beirut again tonight. Reporter tonight, intense fire between israel and hezbollah. World leaders fearing a broader regional conflict with unimaginable consequences. The Chaos And Fear here on the streets of beirut seen in video circulating online. Israel saying it took out a top Hezbollah Commander, but the militant group not commenting. Over the last 24 hours, Israel Firing 2,000 rockets and missiles on what it says are hezbollah targets. Casualties are mounting, according to lebanese officials. Over 500 are dead, including children, and over 1,800 injured. So many parts of the country left smoldering in ruin. Residents running for their lives. These videos given to abc News Document the terrifying journey of one young woman, gia. Explosions everywhere. This time yesterday morning, This school was completely empty, but in a matter of hours, thousands and thousands of people flooded here from the south. Now its at capacity. We met one family here who made that same terrifying journey, traveling for 20 hours. Two parents and their five children. Baby mohammed just 8 months old. Hassan, who didnt want to show his face, says there was a lot of panic. His children crying in terror as he says rockets kept landing around them as they tried to get out. President biden at the u. N. , saying the world is now at an inflection point. Full Scale War is not in anyones interest. Even if the situation has escalated, a diplomatic solution is still possible. Reporter david, a senior official telling our Martha Raddatz says theres going to be another round of massive attacks with israel mobilizing Ground Forces for raids. David . David ian, thank you. Our team in the middle east, thank you. President biden, after addressing World Leaders at the ub, will sit down with exclusively with the hosts of view here on abc tomorrow. His first interview since that debate in june. Thats at 11 00 a. M. Eastern right here on abc. Meanwhile, 42 days to go until the election. Donald trump and Kamala Harris on the economy and on immigration This week. Former President Trump in georgia, Vice President harris headed to pennsylvania, and then to the border in arizona. And the new polling tonight, several new national polls showing Kamala Harris with a slight edge over Donald Trump, but within the margin of other record. And in the key battleground states, several states with Donald Trump with a slight edge, others with Kamala Harris with the edge. This is a very close race. Heres Rachel Scott. Reporter tonight, in battleground georgia, former president Donald Trump zeroing in on the top issue for voters, the economy, promising that if he wins, the u. S. Will scoop up manufacturing jobs from other countries. Were going to take their factories. American workers will no longer be worried about losing your jobs to foreign nations. Instead, foreign nations will be worried about losing their jobs to america. Reporter trump says hell bring business back home by slashing taxes and regulations, and by imposing sweeping tariffs on foreign imports, something Vice PresidentKamala Harris says will drive up prices on everything from groceries to gas to medicine. Many economists agree with her. And today, the senates top republican says he does, too. Im not a fan of tariffs. They raise the prices for american consumers. Reporter the Vice President s Team Pointing to the more than 700,000 manufacturing jobs created during the biden harris administration. Harris today leaning into whats become a defining issue for her campaign, abortion, saying she wants to abolish the Senate Filibuster to restore Reproductive Rights as they existed under Roe Versus Wade with a simple Majority Vote instead of the twothirds vote now required. Ive been very clear. I think we should eliminate the filibuster for roe and get us to the point where 51 votes would be what we need to actually put back in law the protections for reproductive freedom. Reporter trump has boasted of Nominating Three Of The Supreme Court Justices who overturned Roe Versus Wade, keenly aware hes paid a political price with we mall voters. The former president now making an allout appeal to the women who are concerned about abortion rights. I am your protector. I want to be your protector. As president , i have to be your protector. You will no longer be abandoned, lonely, or scared. You will no longer be in danger. Youre not going to be in danger any longer. You will no longer have anxiety from all of the problems our country has today. You will be protected, and i will be your protector. Women women will be healthy, confident, and free. You will no longer be thinking about abortion. Thats all they talk about. Abortion. Reporter but tonight, a Harris Campaign Spokeswoman with a blunt response after ripping away our reproductive freedom, now hes trying to tell us how to think. David lets bring in Rachel Scott here with us. A rare moment in studio in new york instead of on the campaign trail. We so appreciate your long hours on the campaign trail. So, weve got former President Trump in georgia, on the economy. Weve got Vice President harris going to pennsylvania on the economy, and then shes going to arizona to the border. Reporter both of these candidates keenly aware that immigration and the economy are top issues to voters. Harris will be delivering that speech on the economy in pittsburgh, and then, she travels to Battleground Arizona with a visit to our southern border. Shes expected to tout the biden administrations Executive Action that led to a significant drop in the number of migrants crossing the border. Che shes also expected to say Shed Sign that bipartisan Border Bill into law. David Rachel Scott, great to have you. We continue now with the news tonight, and to Capitol Hill now, where hall of Fame Quarter brak back brett Favre T revealed his parkinsons diagnosis. Here on that, trevor ault. Reporter tonight, stunning news from controversial Nfl Hall of Famer Brett favre, revealing hes battling parkinsons disease. Ive recently been diagnosed with parkinsons. This is also a cause dear to my heart. Reporter the 54yearold former quarterback sharing the Diagnosis Today during testi testimony. Parkinsons disease is a neurodegenerative disorder that causes parts of the brain to deteriorate, affecting movement and cognition. Favres 20year career possibly made him more susceptible to the disease. Hundreds, probably thousands of concussions, including This careerending one in 2010. Its one of the few times i kind of went blank there for awhile in my career. In general, repeated hits to the head are linked to neu neurodegenerative diseases. Concussions and even subconcussive hits can alter Brain Structure and chemistry. Reporter and a new study shows 1 in 3 former nfl players surveyed believe they have the neu neurodejennive disease cte. Favre sharing his experience on the Football Field in the new documentary concussed. I cant tell you how many times my head hit the turf and stars, or fireworks or whatever went off. I didnt think that was a concussion. Its hard to even put a number on how many of those i had. Reporter david, the average age of onset of parkinsons is the early to mid 60s. Favre is just 54. Some are diagnosed in their 50s, regardless of their career. David . Reporter trevor, thank you. Overseas tonight, and to an investigation involving suicide, which is legal in switzerland. Tonight here, the case of an american woman believed to be the first person to use whats called a Suicide Pod in switzerland. The 64yearold Woman, from the midwest, reportedly suffered from an autoimmune condition. He