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still the most potent weapon, getting fully vaccinated. research showing the pfizer vaccine is 88% effective against the variant after the second dose, but just 33% effective after one dose. >> communities that are not well vaccinated, that haven't hit vaccination targets that we're looking for, are those that are going to be most at risk in the future. >> reporter: some southern states are among the least vaccinated in the country. >> at one time we had cars lined up all the way around getting the shot. >> reporter: in forest, mississippi, this vaccination site almost empty. community leaders worry about another surge. >> come in and get the shot. it's far from over. let's take every precaution. because we're not out of the woods yet. >> reporter: today chicago and washington, d.c., joining other major cities to fully re-open as the country inches closer to a horrific milestone -- nearly 600,000 lives lost. the family of shanetta wilson says she was pregnant, waiting to get the vaccine because of underlying health conditions when she got covid.