Operator Good morning, and welcome to Ionis Pharmaceuticals' Fourth Quarter and Full Year 2020 Financial Results conference call. [Operator Instructions] At this time, I would like to turn the call over to Wade Walke, Vice President of Investor Relations to lead off the call. Please begin. D. Wade Walke -- Vice President, Investor Relations Thank you, Tom. Before we begin, I encourage everyone to go to the Investors section of the Ionis website to find the press release and related financial tables, including a reconciliation of the GAAP to non-GAAP financial measures that we will discuss today. We believe non-GAAP financial results better represent the economics of our business and how we manage our business. We also have posted slides on our website that accompany our discussion today.