Hypertension, tobacco top most causes of premature mortality By IANS | 0 Views How hypertension can affect male fertility.. Image Source: IANS News New Delhi, May 20 : Hypertension and tobacco are the top most causes of premature mortality and people consuming tobacco in any form are at high risk of many diseases, as nicotine is solely responsible for constricted arteries, heart failure, inflammation, many types of cancers, blindness, and gangrene, while it also complicates existing hypertension. The above was mentioned by noted interventional Cardiologist Dr. (Prof) (Col.) Shekhar Kashyap while speaking at a webinar on 'Hypertension, COVID-19 and Tobacco - A Deadly Triad'.