Here’s how a seasonal shot may prevent Lyme disease Updated Mar 04, 2021; STATEN ISLAND, N.Y. — A new seasonal shot to prevent Lyme disease could be available in 2023, according to researchers at MassBiologics, a nonprofit unit of the University of Massachusetts Medical School, Worchester. Researchers are starting the first human clinical trial of the shot, called Lyme PrEP, according to news releases from the University of Massachusetts Medical School Communications. The pre-exposure prophylaxis developed by MassBiologics uses a monoclonal antibody that protects humans against the disease. But this shot isn’t a vaccine, researchers say. Instead, it would be given as a yearly injection before tick season begins.