relatively safe, participants are warned about everything from headaches to liver damage. that's why jennifer martinez only enrolls in trials that promise side effects won't be severe. >> i do ones that i don't think are crazy, that have, you know, normal side effects. >> reporter: peace of mind for this mom giving up a piece of herself in the name of science. some things to remember about the trials, don't treat this as free medical advice. remember, you are a test subject, not a patient. also find out who pays if something goes wrong. remember most importantly, the higher the pay, the riskier the trial. andrea canning, abc news, new york. >> do that cash/risk assessment, folks. >> especially moms. coming up, lightening the mood when we come back. including the sexiest woman of all time. >> and one of oprah's favorites will sign off of his talk show. stay tuned for "the skinny."