this is cnn breaking news. >> hello and welcome to our viewers in the united states and around the world. i am john vause live in lviv, ukraine, and what could be the start of a definitive value batle for ukraine. the long-awaited russian military offensive in the dop bas region appears to be underway in the frontline which stretches for hundreds of miles. >> i am paula newton at cnn world headquarters in atlanta, where masks are now optional throughout the united states, onboard planes, trains, and buses, after a judge strikes down a public-transit mandate. for books, ukrainian, nato officials woorned the russians were preaching for a renewed offensive in the east. now, it seems it has begun. ukraine's top security official, a 300-mile front line stretching from kharkiv, donetsk, and luhansk region came under attack by russian forces monday. for the most part, that defensive line held. the city in western lieu hans ks was repeatedly hit by artillery, igniting heavy fires across the city, smoke filling the sky line. a senior defense official says moscow may have changed tactics after suffering humiliating defeats in the north. each btg consists up to 800 troops, which means tens of thousands of russian soldiers. but ukraine's president says despite being outnumbered and outgunned, his country will not give up the fight. >> reporter: russian forces have started the battle for donbas, for which they have been preparing for a long time, and a considerable amount of the russian forces are concentrated and focused on that offensive. no matter how many russian servicemen they are bringing into that area, we will keep on fighting and defending and we will approximbe doing this dail >> and there are new images from mariupol. ekes of heavy fighting have decimate d the port city. the russians, now in near-toll control. a sprawling steel factory on the azov sea. a ukrainian commander in the city says hundreds of civilians have been sheltering there, as well. he says russian forces are aware of their presence and they are firing on the plant, anyway. >> translator: right now in mariupol, at the azov factory, hundreds of civilians are sheltering. among them are children of all ages, women, the elderly, and the families of mariupol defenders. they are sheltering in the basements and bunkers from the russian world. >> and as this war enters a deadly new stage, u.s. president joe biden, expected to hold a call with allies in the coming hours to discuss continued support for ukraine, as well as efforts to try and hold russia accountable. here, in western ukraine, city the lviv has been a relative-safe harbor from this war but russian missile strikes shattered that sense of security monday. video captured one missile streaking across the sky on the way to its target. ukrainian officials believe four struck lviv, killing at least seven people, injuring 11 others. details now from cnn's matt rivers. >> reporter: lviv has largely been spared the horrors of this war, which made the black smoke in monday's skies so unusual here. we chased one such plume until we arrived at its source. flames shooting out of two buildings as firefighters rain water down from above. ukrainian officials say at least four missile strikes, across lviv on monday morning, three of which hit military infrastructure sites. another, hitting just across these railroad tracks behind me. let me show you the imt pact crater from where ukraine yan officials say that russian missile struck. military and sufficient responders on the scene quickly thereafter. the explosion, destroying an auto-repair shop and a dozen-or-so cars lined up outside. the explosion's shock waves blew w out windows more than 500 feet away. i got very scared she says and i was scared the whole building was going to fall down. i don't know whether i should stay here in this building or if i should move to poland and flee for my life. overall, the four strikes across the city killed at least seven people, and injured about a dozen including a child. here, scenes from a hospital treating victims of the strike that survived. other victims in body bags outside the repair shop where that they worked. the opener said they were just getting ready to open the business for the day when the miss lts struck. four of his employees were killed ask several others sent to the hospital. and what appears to bes such an obvious non-military target, was this a mistake by the russian military? or was this place targeted on purpose? the owner told us the only vague connection his shop had to the military is volunteering time to make sure cars being sent to soldiers at the front where are in good shape. for him, this is just another example of russian' military brutality. he says they die astroour infrastructure. they kill people. they want to kill and destroy the ukrainian nation. several of those who died have families with young children. so instead of leaving work to go home and see them, their bodies were taken to the morgue. more victims in a needless war. matt rivers, cnn, lviv, ukraine. >> joining me now, daniel davis, retired u.s. army lieutenant colonel. now, seen your expert for a washington-based thinktank. colonel, good to see you again. we had this offensive in the east appears to be under way. what are key indicators in the coming days that you will be looking for ukrainians are holding their own? >> yeah, what's going -- what we can expect, versus what we started to see really today -- and that is a saturation bombing that russia, historically, will saturate an area with artillery, with rocketfire, and with airpower and those are the key things they are going to use to, quote, soften up some of the targets. along this very long line here, only known to russia, they have selected probably several points where are they are going to try to make penetrations in. so one of the things we will see after this softening up here, which could be anywhere from one to three days is that then some of this russian armor that you just refer today will probably try to start making a breakthrough. their intent would be break through the front lines and get into the rear areas, and potentially cordon off certain parts of the ukraine forces and try to destroy them in piecemeal. what we look for if the ukrainians are successful, if if they will prevent those penetrations and be able to louisiana local counterattacks in depth of the defensive positions so if they make penetration, they will able to hit it in the flank and cut it off quickly. that's the going to be the key to how this battle unfolds. >> ukraine's president spoke about the missile strikes and air attacks over the past 24 hours. here he is. >> translator: the russian army is not slowing down the use of the missiles against ukraine. they are pressuring. looking for a weak spot in defense of our state to find and enter there with the main forces. >> so essentially, confirming what you have been saying but he also added he believed because of international sanctions, moscow may have some trouble resupplying those missiles and going through them at quite a rate. how do you see it? >> well, without a question, because it -- it takes a long time, even without sanctions, to replenish those missiles because it takes, often, months to -- to make a new one. so there is no doubt that the -- that the inventory continues to go down but that's when you are going to see an increase of use in heavy artillery, which they can really make thousands and thousands of rounds without too much difficulty. and in the airpower with the so-called dumb bombs, they will keep those precision-guided munitions for the high-value targets and unfortunately, i don't think they are that short of them right now pause they have been preparing for this for quite some time. >> and the air strikes here in lviv about 24 hours ago, also damaged rail lines. there any assessment how badly damaged those rail lines are and the impact that could have from transporting aid from nato and u.s. allies? >> that is exactly right. and -- and that is the -- the big concern because to really to have a good chance to hold on, ukraine is going to have to have weapons whether it's tanks, heavy artillery, or long-range missile systems. and -- and infantry fighting vehicles, armored vehicles. he they have got to have those. we just provided a bunch. several overs have provided them, too. the problem is those things can't just be driven there. they have to approximate put on either railcars or heavy equipment transports obt road and there is only three bridges over the dnipro river right now and if they take any of those bridges out, it will make it very difficult to get through and we already know russia's b disrupting spots on the rails and if they continue to do that, it is going to make it very difficult, no matter how much equipment we give them for it to actually get township the fight. >> very quickly, cnn.com right now, worth a read. you say the main gzeal goal app- militarily tharks looks like a far more attainable objective from-let neighbor target of kyiv. we are talking about 40,000 at least of the best ukrainian fighters. that is the goal for russian' offensive. why not just pull them back to safety in ukrainian territory? >> that's what i argued several weeks ago. i said ukraine probably needed to have a plan where they would fight what is called a fighting withdrawal to where you continue to exact press on the attackers. but you have preplanned, fallback lines to where you have defensible positions so you don't get flanked and it appears ukraine has chosen that they are going to stay in the defensive positions, and just see if they can hold out. that is an option. i wouldn't have done it if i was in charge but we will see how it works out. they probably know more than do. >> we will see. colonel, thank you so much. peesht are your time. appreciate you being with us. >> thank you. >> well, kramatorsk, the donetsk region says at least eight residential build gts were destroid, as well as educational and infrastructure facilities, and the artillery shelling lasted throughout the night. cnn's ben wedeman has more from this once-puslibustling city whs now practically desert d. >> the playgrounds are empty. the pigeons indifferent to the air-raid siren, and so it would seem are the people. i close my others when i am walking around, says nikolai, because it's all the time. as fighting flares to the east, north, and south, the few residents left in kramatorsk carryings on. the train station ten days ago of a russian missile strike that left almost 60 dead is closed. trains don't come here anymore. the buses, oddly enough, still run. overnight, a russian missile struck. there were no injuries, this time. nearby, signs of an earlier bombing. after almost two months of war, constantine is fatalistic. i am not suicidal, he says, but as long as other people stay here, i will stay here. kramatorsk is blunt about the perils his city faces. >> it's not safe. it's dangerous in each part of the city. you can be attacked in every place of the cities. >> reporter: elisa and her husband stroll through the city's main square. >> this is very brave and but we want live in ukraine. >> reporter: for now, they havemont have most of their city to themselves. under normal skraptss, on a mild-spring evening here in the main square in kramatorsk, there would be lots of people here. now, just lots of pigeons. curfews approaches and dogs abandoned by their owners roam the empty streets. ben wedeman, kramatorsk, eastern ukraine. >> we will take a short break. when we come back, in the united states, a court has ended the mask mandate for pub transportation. jubilation, some concern from others. we will have response from the white housuse when we come back. ♪ ♪ ♪ ♪he'd better not take the ring from me.♪ we need to reduce plastic waste in the environment. that's why at america's beverage companies, our bottles are made to be re-made. not all plastic is the same. we're carefully designing our bottles to be 100% recyclable, including the caps. they're collected and separated from other plastics, so they can be turned back into material that we use to make new bottles. that completes the circle and reduces plastic waste. please help us get every bottle back. ♪ ♪ we believe there's an innovator in all of us. ♪ that's why we build technology that makes it possible for every business... and every person... to come to the table and do more incredible things. bipolar depression. it made me feel trapped in a fog. this is art inspired by real stories of bipolar depression. i just couldn't find my way out of it. the lows of bipolar depression can take you to a dark place. latuda could make a real difference in your symptoms. latuda was proven to significantly reduce bipolar depression symptoms and in clinical studies, had no substantial impact on weight. this is where i want to be. call your doctor about sudden behavior changes or suicidal thoughts. antidepressants can increase these in children and young adults. elderly dementia patients have increased risk of death or stroke. report fever, confusion, stiff or uncontrollable muscle movements, which may be life threatening or permanent. these aren't all the serious side effects. now i'm back where i belong. ask your doctor if latuda is right for you. pay as little as zero dollars for your first prescription. my name is ami and i bought and financed my car through carvana. everything was all good but then things hit a slight snag. ok so they were trying to verify my employment status while i was at work, in a giant hole, in a mine. but then something amazing happened. hello? 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>> it's really confusing, paula, because for the last-several months and many months, cdc has tolgd us that masks were required for travel and that masks were a form of mitt digat to slow the spread of covid-19 and this one judge sitting in florida, judge who hasn't been on the bej a good-two years has made this sweeping ruling literally, within an instance, changes the way we will travel and the biden administration has said it's not clear in terms of what it's going to do. if it's going to file an appeal and i think that just creates even more confusion because if we are to believe this mask mandate was necessary to lessen the transmission of covid-19, it is really unexplainable as to why the biden administration won't challenge it. i roids it was due to expire in a couple weeks but i am concerned this really sets a precedent and says that the cdc and presidential administration cannot enact, you know, decisions like this mask mandate even in the face of a public-health crisis. so i think there is some bigger issues here that need to be looked at. >> i am so glad you brought that up because, in general, they have -- this judge has decided the cdc couldn't do this. it is not like the judge decided well, from a public-health perspective, we don't need this anymore. it was completely different in terms of the legal ruling. >> absolutely. she said that this the -- the -- basically, the mask mandate, in its entirety, has been illegal from its inception. she says this procedural act was not commented, public comment wasn't allowed to take place and by violating this procedural rule, this -- this law, this procedural law, that the mask mandate basically should have never gone into place. and now, that flies in the face of what other federal courts have said. even the supreme court and definitely flies in the face of what the public-health officials have been telling us for months and months about the need to wear masks as we travel through crowded airports ask crowded train stations. so again, i just think this -- you know, just really erodes the public' trust in the cdc and the administration if it does not challenge this ruling. >> not to mention, as you said, confusion with the legal system. now, andy slavitt is a former adviser to president biden on covid, had this reaction on cnn earlier. i want you to listen to it with me. >> this is kind of a victory for mob rule. this has been a huge burden on flight attendants who have had to enforce a very small number of very loud and uncivil folks who have basically said, you know, i dare you to enforce this mask mandate. >> you know, he brings up a lot of what you were alluding to earlier. but also, the other issue is what flight attendants, tsa workers, have any legal grounds themselves to appeal this because this could compromise their health? >> i think we may see lots of lawsuits. the question is, paula, who files first? because it's not clear, as i said, that the biden administration is going to challenge this but i agree with what andy said. basically, this is a decision made for maybe the convenience of those that have to enforce this rule. main, it is a business decision but it flies in the face of what we have been told in terms of what the public-health experts say was the necessity of the mask mandate and that's what has people so confused. are these rules being eliminated because it's in the best interest of businesses? or is it in the best interest of the public? and if the biden administration again doesn't challenge this rule, i think it just adds to the confusion and adds to the sense that we can't trust these are rules that are being decided to keep us safe, versus to promote big business. >> yeah. and as you say, the domino effect of that could be quite profound. areva martin for us, thanks so much. appreciate it. >> thanks, paula. now, dozens of chinese cities are under full or partial lockdown, as authorities there try to curb the spread of covid-19 under the country's strict zero-covid strategy. but an increasing shortage of food, medicine, other critical supplies due to disrupted supply chains is fueling growing problems and public frustration. cnn's steven jiang is following this story from beijing, and steven, you guys have been bringing us this story, day after day, with residents looking for lee relief, being incredibly frustrated. what is the latest from there now? >>. >> paula, the grim reality is millions of people across china, including the 25 million or so residents in hshanghai continue to be sealed in their homes, many facing shortages of food and supplies, despite repeated government pledges to increase the distribution channel. the form of video showing workers dumping a large amount of perfectly-looking vegetables that were intended to be sent to shanghai residents in great need of groceries. local officials, later, insisted those vegetables had rotten inside and had to be disposed of and another rather disturbing development in shanghai is authorities there are now further tightening the reg regulations in terms of sending all positive cases and their close contacts into government-run isolation wards with no more exception. so that has meant a growing number of senior citizens, some of them in their 90s, being forcibly taken out -- out of their homes, and being sent to those facilities that are often in very crowded and primitive conditions but this is not just happening in shanghai. this is actually happening across china because -- because of the lockdown measures are being enforced in many places. some of them only have one or several cases. and in the least one instance, a city not far from beijing, authorities locked down their entire city when there were no cases at all, they later explained they were doing that in preparation for -- for a citywide mass testing. so, this is really, in a way, reaching a level of absurdity, according to many outside observers but the reason, of course, is also very clear because the central leadership here has made clear zero covid is here to stay and this is according to them, still the best way to protect people's health ask avoid all the deaths and destructions caused by covid in the west. and that's why for many local officials, this has become a political test of sofrt, if you will, the lesson they have drawn from what is going on in shanghai is when it comes to lock downs, you have to do it early, have do it big instead of how almost impossible it is to contain omicron given its highly contagious nature with those measures. but at end of day, paula, this as you know is -- is a country lun by now an increasingly powerful leader and he has put his personal stamp of approval on this policy so we are not going to see local officials change course anytime soon, mau la. >> no, in fact, seem to be doubling down for it. steven jiang for us in beijing, thanks so much. we will head bang to ukrien after a short break, as cnn visits at eastern city directly in the line of fire, and russia begins the battle for the donbas region. what the locals think of putin there? 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welcome back, everyone. i am john vause live in lviv, ukraine. breaking news from the war here, where president volodymyr zelenskyy says russian forces have started the battle for the donbas region. moscow-backed separatists have been fighting for control of the industrial heartland seance 2014. cities key to establishing a land corridor from the donbas to the crimean peninsula, which russia annexed illegally. >> reporter: an art and prayer from worshippers under the shadow of russia's war. with he ask for your mercy, lord. please, hear us. they have gathered here for orthodox palm sunday. carrying willows, instead of palms, per the orthodox' tradition. it's supposed to be a celebration of jesus's return to jerusalem, but there is little joy in this congregation. ukrainian officials say this city will be a decisive battleground in russia's imminent defensive in the donbas re region. the streets are getting emptier, as the fatephyting gets closer. those still here are are being urged to leave. the air-raid siren is an unrelenting wail. we have heard a steady stream of booms coming from that way, in the distance. but as you can see, people here are just used to it. the children continue to play. the adults tday strong. this group is awaiting an evacuation bus to the safety of western ukraine. she tells us she is taking her grandchildren to lviv. their mother died three years ago. you hear what is happening here, she says. my husband is still at home. his health isn't good enough to make the journey. her granddaughter offers some support. oh, grandma, she says, i love you. anna is full of anguish that the international community has failed to reign in putin. when they show the children killed, i can't. i cry, she says. why can't they stop this one idiot? if they will send me, i will shoot him. seven weeks into this ugly war, there is no end in sight. pablo is saying good-bye to his wife olga. she doesn't want to let go of him. scenes of separation that have become all too familiar. everything will be okay, the organizer tells her. comforting words that mask a grim reality. >> cnn's clarissa ward reporting from ukraine. well, images on social media seem to support ukraine's claim that the russian arship moskva was hit by two anti-ship missiles. video clip show as huge plume of shoek pillowing from the ship as it lifts to one side. and shows large black holes on the port side of the vessel just above the waterline. notably, the jagged edges are pointing inwards, not outwards, which would have been indicative of an internal explosion. russia's flagship missile cruiser sank in the black sea last week. one other point here. moscow claims the cruiser went down during a storm. as you can see by these images, there was no storm. i will have a lot more from lviv at the top of the hour, but let us for now, let's head to cnn world headquarters and pay la newton. the israeli defense forces say it is in response to rocket fired from gaza into israel earlier in the day. idf say the rocket was intercepted by the iron-dome defense system. tensions in the region have been escalating for weeks anyway. monday's rockets were the first fired toward israel in months. football superstar suffers a terrible loss. cristiano ronaldo and his partner issue a message about their late newborn son. we will have the details when we come back. stuff. we love stuff. and there's some really great stuff out there. but i doubt that any of us will look back on our lives and think, "i wish i'd bought butan even thinner tv,f us found a lighter light beer, or had an even smarter smartpne." do you think any of will look back on our lives and regret the things we didn't buy? or the places we didn't go? ♪ i'd go the whole wide world ♪ ♪ i'd go the whole wide world ♪ discover a simple way to use colors in managing diabetes! inspired by nature, onetouch verio reflect® meter shows instantly if you're below, within or above your range. it cheers you on and provides guidance. connected to your health and your phone. visit onetouch.com today. i am here because they revolutionized immunotherapy. i am here because they saw how cancer adapts to different oxygen levels and starved it. i am here because they switched off egfr gene mutation and stopped the growth of tumor cells. there's a place that's making one advanced cancer discovery after another for 75 years. i am here... i am here.... because of dana-farber. what we do here changes lives everywhere. i am here. the president of south africa says they have declared a state of disaster. a week of torrential rains left thousands homeless, more than 440 people dead, and advertises still missing. dozens still missing. 10,000 troops are helping with rescue missions and providing medical support. cnn's zain asher has more. >> reporter: a rescue team on a mission to find a woman missing since torrential rains swept through parts of south africa. they zero in on the river. it's where rolocals say nay fou remains of victims. >> we are sure she was swept by the river because we was found her son because haven't found her. >> it is just one of several search operations under conditions way in and around durbin, where emergency workers probe the banks of rivers and sniffer dogs comb through piles of debris. one relief attorneys who just returned from the area says he hasn't seen this kind of flooding in decades. >> they have lost everything. and they have seen their houses opinion swept away. they have seen their livelihoods been swept away ask the situation is really quite dire. >> reporter: officials say 10,000 troops have been activated to provide support for rescue missions, as well as to help clean up and bring aid to the more than 40,000 people left homeless from the floods. disaster management workers and volunteers are packing water and other spupplies to deliver to communities without clean water and power. some places are already getting help, now that floodwaters have receded in some areas but authorities say many roads and bridges are damaged or washed away. the devastation is so widespread, south african president cyril ramaphosa, declared a national state of disaster. >> this is a humanitarian disaster, that call for a massive and urgent relief effort. the lives, health, and wellbeing of thousands of people are still at risk. >> reporter: with dry weather expected, officials hope to begin the long process of reco recovery skan asher, cnn new york. >> police in sweden arrested 26 people and more arrests are expected after a weekend of vio violent riots and protests other koran burnings. the clashes broke out over several cities, 40 people injured including police and protestors. the vi lens wiz triggered by a far-right group's burning of the quran. cristiano ronaldo ask his partner are mourning the loss of their newborn son. they announced the loss along wt the birth of his twin sister. cnn's don riddell has the story. >> reporter: just the moufl most powerful news coming out of ieng land monday night where cristiano ronaldo announced his baby boy had died. the portuguese scored the 50th hat trick of his career on the weekend, posted a statement on social media that he co-signed with his partner. they said quote it is with our deepness saddent we have to announce our baby boy has passed away. it is the greatest pain any parent can feelment only the birth of our baby girl givens us the strength to live this moment with some hope and happiness. we would like to thank doctors and nurses for all their expert care and support. we are all devastated at this loss, ask we kindly ask for privacy at this very difficult time. our baby boy, you are our angel. he wil we will always love you. ronaldo is one with of the greatest football players of all time. one of the most marketable athletes on the planet and there was outpouring and support on social media immediately after the statement was posted. he often poses with his son christiano jr. his twins eva and mateo and another daughter martina must all be hurting so painful right now. ronaldo would have been expected to start for united in tuesday on a crucial premiere league game against their biggest rivals, liverpool. the liverpool club itself experienced terrible tragedy. they just marked another anniversary of the stadium disaster. it will surely overshadow anything that happens at anne field. remember, football is just a game. back to you. just ahead here for us. one ukraine crane family was forced to go to russia to flee the fighting in their city. find out how a relative arranged for them to be reunited in poland. living with metastatic breast cancer means beieing relentles. because every day matters. and having more of them is possible with verzenio. the only one of its kind proven to help you live significantly loer when taken with fulvestrant, gardless of menopause status. veenio + fulvestrant is for hr+, her2- metastatic breast cancer vthat has progressed after hormone 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(music throughout) a u.n. deputy has issued a grim assessment on the prospects for any sort of truce in ukraine. the conflict has killed more than 2,000 civilians. that's according to the u.n. but it's of course believed to be that the true death toll is much higher, especially in places like the besieged city of mariupol, where people are desperate to escape. listen. >> cease-fires, they're not on the horizon right now, but they may be in a couple of weeks. they may be a little bit longer than that. it will all depend on two things -- the war, of course, where that's going. your guess is as good as mine. and the talks. >> okay. some 5 million people have fled the fighting in ukraine so far, and more than 7 million others are internally displaced. now, as their homes and families, of course, come under attack, some ukrainians are forced to do the unthinkable. that's flee to the country that's bombing them -- russia. the thought of their loved ones being trapped in enemy territory can be a terrifying prospect for relatives safe in the west. salma abdelaziz reports on how one woman had to deal with smugglers to get her family out of russia. >> reporter: mila does not trust the man she's about to meet. he is a smuggler. she is anxious, looking for her mom and sister, hoping they are here. it's vita, her sister. brief joy, but there's no time to hug her mom. the smuggler wants to be paid now. 500 u.s. dollars for the pair, much more than most families fleeing war can afford. we pull away with her mom, luba. we don't want our presence to call problems. away from our camera, mila is extorted for more cash. getting to safety is dangerous. this is the story of one family's escape into russia after its troops bombed and occupied their city. they are from azun, a city under siege. mila's phone was filled with videos like this. living in cleveland, ohio, she had no way to call her family, no way to find out if they were alive. so this is your room? we first met mila a day earlier at this refugee shelter where she volunteers. >> somebody said that missile actually hit my backyard, and i was crying so bad. i just didn't know. >> how did you deal with that? >> i came to poland to take that energy and convert it into something. >> reporter: she finally got a call, but it was not from azun. >> i heard them for the first time after whole month. i was so torn. i was happy they alive, but i was terrified that they're in russia. and i don't know. should i be happy, or should i be sad? >> reporter: mila's only option, she says, was to hire a smuggler to drive her family from russia to safety here in poland. >> somebody from poland gave me a number of people who transport, smuggling basically. obviously it's dangerous, dangerous activity in russia. very dangerous. >> reporter: now they are reunited, but how did the victims of putin's war end up in russia? desperate to flee, they tell us they could only find one way out. a private driver offered a ride to the russian border. >> now they fill me in to details, and it was actually even worse than i thought. i already was terrified. >> were you scared to go to russia? >> they needed to go somewhere to escape that. >> reporter: thousands of ukrainians have faced the same. many say they had no choice. it was go to russia or die. salma abdelaziz, cnn, on the poland/ukraine border. if you would like to safely and securely help people in ukraine who may be in need of shelter, food, and water, please go to cnn.com/impact. you will find several ways there you can help. i'm paula newton at cnn center in atlanta. thanks for joining us. we will be right back with john vause live from lviv, ukraine, after a break. ♪ we believe there's anan innovator in all of us. ♪ that's why we build technology that makes it possible for every business... and every person... to come to the table and do more incredible things. meet ron. that man is always on. and he's on it with jardiance for type 2 diabetes. his underhand sky serve? on fire. his grilling game? on point. and his a1c? ron is on it. with the once-daily pill, jardiance not only lowers a1c... it goes beyond to reduce the risk of cardiovascular death for adults with type 2 diabetes and known heart disease. and jardiance may help you lose some weight. jardiance may cause serious side effects, including ketoacidosis that may be fatal, dehydration that can lead to sudden worsening of kidney function, and genital yeast or urinary tract infections. a rare life-threatening bacterial infection in the skin of the perineum could occur. stop taking jardiance and call your doctor right away if you have symptoms of this infection, ketoacidosis, or an allergic reaction, and don't take it if you're on dialysis. taking jardiance with a sulfonylurea or insulin may cause low blood sugar. a once-daily pill that goes beyond lowering a1c? 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