I could come up with a date predicting when you would die. Well, thanks, but maybe the way that the years play out isnt inevitable. So, how about the idea of being able to increase our health span live the better years of our lives for longer, feel like were a0 at 60 . There is 15 17 years of healthy life that is up for grabs for all of us. We head to california to meet the scientists and founders who want to make it a reality. Ageing by itself is the largest risk factor for every single disease, Chronic Disease of ageing. So by targeting it, you target all disease together. But how do we separate science from snake oil . The Longevity Industry is worth billions, with hopes of delaying disease, extending our sprightly years and maybe even throwing in a few extra. I let a system of science and data run my body. It does a betterjob taking care of me than i can. Maybe even our Furry Friends can be with us for longer. He just sneezed in my face and the things some people will do to stay young push it out, push it out. You got this. Do you consider yourself a guinea pig . No, i dont i consider myself to be an explorer on the frontiers, trying to find out whats possible. Tech entrepreneur bryanjohnson is spending millions trying to turn back time on his body. I refer to myself as a professional rejuvenation athlete. Its a new sport i want to create. Im not a bio hacker, im not a health enthusiast, i am a professional rejuvenation athlete. I love it. Working with a team of 30 scientists, his daily life is dictated by an extreme regime of fitness, diet, tablets, tracking and treatments. I am chronologically 45 years old. Biologically, im a few hundred ages. My left ear is 64. My fitness test say im 18. My heart is 37. My diaphragm strength is 18. And i playfully say im trying to become like an 18 year old. My son is 17 and so, i always tease him and say, when i grow younger, i want to be like you. Wheres he taking me . Brilliant. Wow where to start in here . Whats this . This is High Frequency electromagnetic stimulation. We got this machine because we were trying to solve a problem. Every night, i was getting up one time per night to go to the bathroom, and when i do so thats actually normal but when i did so, it produced less quality sleep. Of course. So i wanted to see if i could get up zero times, so we got this machine to trial, could we strengthen my pelvic floor and my bladder so that i wouldnt have to get up at night to go to the bathroom . Do you want to try it out . Do you want to just sit down . 0k. Is it going to vibrate or something . So, its actually a lot of women use this after having babies to rebuild the strength of their pelvic floor. A lot use kegel exercises. Yeah. This is basically kegel, just through stimulation. Right. Im going to turn it on. 0k. And the feeling is going to be a little foreign and it might be shocking initially. 0k. Zapping oh, its like pins and needles. Its sort of tickling, but tickling in a quite hard, aggressive way. How long do you need to do it for . The session is 30 minutes. But actually, its been successful. Is this one of those devices that measures the age of your skin . Thats right. Hows yours doing . Weve made about 22 years of progress in reversing the age of my skin. It takes all these images of your face and you get about ten reports on pore size, uv spots, reds, browns. Your skin is amazing is this just from your regime or is there other help . Other help, too we have some lasers over there, which ill show you. But theres no injections, thats just from everything in here . Thats right. What do we have next . This is something that also tells you the health of your cardiovascular system, so your age. It looks at advanced glycinate products in your skin. So if you want to try it, you can put your arm on it and it will tell you your age. Ideal score would be around two. Right. So im only a little bit too old for my age it could be worse. Whats next . 0k. This is an ultrasound machine, medical grade. This is what youd see in a hospital. Are you having a baby . Laughs who knows, with what youre getting up to already what are you actually using it for . So we look at the brain, the lungs, the heart, the pancreas, the prostate, tendons, ligaments everything. Its really a useful technology to have in the clinic to do on a routine basis. How do you feeljust before you do any of this tracking . Do you get a bit nervous, hopeful . Do you have expectations . It is a game. Some of my most happiest days are when we do these full measurement days. Inaudible thats a lot better whats your motivation . Are you doing this for yourself or for humanity . When i was 21 years old, i decided that i wanted to spend my life doing something meaningful for the world. And i didnt know what to do, so i said, im going to make a whole bunch of money being an entrepreneur by the age of 30, then ill decide what to do. And so, for the past since i sold my company, Braintree Venmo i made 300 million and this question was, what could i do that would matter in the year 2500 . And right now, it could be ageing. If we slow the speed of ageing and even reverse it, it would change what it means to be human. Do you think youre risking your health here . In all the things youre doing to protect it, do you think theres also some real risk . Certainly, theres always risks. But theres potentially an argument that we are being more safe than anyone else because we have the rigour of measurement. Whilst bryans signed his life away to experimentation, i visit the buck the worlds First Institute for ageing research. These scientists are working on drugs that they hope could delay age related disease. So, here, i have two of my postdocs, margie and genesis. Would you say there has been huge scientific advancement in this field recently, or is there just a sudden trend for investment and interest in it . The science has matured in terms of, you know, weve been doing this for close to 30 years, understanding the basic mechanism of ageing, number one. Number two, the societal needs are there. You have a rapidly ageing population with an increasing burden of Chronic Diseases. This place is huge this is one of about 20 labs three, two, one squeeze. Its notjust drugs and supplements being put through their paces here, though, its also exercise. One. What kind of exercise, how much, how often . Aerobics, anaerobic, lifting weight, yoga, balance, swimming which one of these interventions actually works the best . But one really important discovery in mice here was the ability to reduce what are called Senescent Cells. These zombie cells play a useful role throughout our lifetimes, but as we age, we acquire many more and as they also lead to inflammation, that increased number ends up providing a hotbed for cancer and all sorts of disease. So, Biotech Companies are trying to create drugs that will reduce that cellular senescence. Im adding my reagent to the eye tissue, so that i can understand which types of cells are senescent. Unity is using this science and its now achieved small early stage Clinical Trials for Eye Injections to treat Macular Degeneration thats failing eyesight that glasses cant fix. Were able to stain the Senescent Cells purple, so that i can visualise spatially, within the eye, where the Senescent Cells reside. Once you get rid of one of these cells, its gone. This would be a small number of treatments over a limited amount of time. One of the things weve started to see is that because the fda will not approve drugs just for anti ageing, companies are looking for a specific problem to treat. Alzheimers disease is an important one, cardiovascular diseases, kidney diseases, Liver Diseases all of these are diseases that are more prevalent as we get older, and to the extent that they have a basis of cellular senescence, these agents were working on could have applicability in other disease areas. What have you got here . That looks like its connected to an eye . So, yeah, we get normal eyes and diseased eyes. We process them into this wax like substance, so that we can section the eye, a Cross Section of it, very thinly and put it on a microscope slide. Here, were testing different drug candidates on our animal models. So we test, in a diseased animal model, does our drug actually inhibit it from forming or get rid of it once it is already formed . A lot of mouse trials have not translated well into humans. We believe that it translates relatively well compared to maybe, like, a tumour of cells and a tumour ina human. Quite creepy, when you know what it is. Yeah i think its quite cool but maybe were missing something. Lifestyle is responsible for about 93 of your longevity. Only about 7 on your genetics, so you cant blame your parents. A lot of exercise, you know, some fasting, a lot of the good sleep, a lot of social connection, very little alcohol. Try to spend at least 11 hours of your 24 hour day without ingesting any calories. This has profound effects on your metabolism, on many of the pathways. So based on the data, i would predict that most people could live to 95, in good health, if they did all of the things that we know will promote a healthy lifespan. But if they work, why do we need to be trying to deal with this Bigger Picture of senescence . Senescence is still going to happen. Hopefully, if you exercise, its going to be delayed by 10, 15, 20 years. I dont mean to be saying that Lifestyle Interventions is all that needs to be done. Theres a need for science for the future. Whats that thing that people do when they sit on the floor and try to get up without using their hands . Whatever erics been doing seems to be working. This is supposed to be some sort of sign of youth, isnt it . If you can stand up by not using your hands and just. How can anyone do that . Pushing your feet down . How is that possible . How do you do that . I dont know i think it means youre under 20 or something. Exactly i cant do it i cant do it. Thank you. Snoring our Furry Friends could get their paws on a life extending pill first, though. I love my dog to bits. Youll notice there are no great danes here, there are no large dogs here, and its because they can have a lifespan of six, seven, eight, nine years you know, almost half that of what a little guy like this could be expected to have. And our hypothesis is that the short lifespan of big dogs is a disease. Hes my honey sweetie, sugar canine my number one pal. We are a senior dog rescue and when we take in dogs like a great dane, for instance, at five years old, theyre already starting to age so much. It would be like a miracle cure if we could have some of our big dogs live longer and live as long as our small dogs. Ms robinson, thats for you. There you go. Where are you at now with the trial . So were kicking off our big, pivotal study. Were trying to understand, does our drug extend life span and quality of life . Its a preventative drug, inhibiting the protein that we believe drives big dogs to age fast. And if everything goes to plan, well hopefully have a drug on market in 2025. If successful, loyal� s drug could hasten the solution for humans as well. Has there been any sort of scientific breakthrough that has made possible what youre trying to do . Yeah, so the things that people dont realise is there have been hundreds of drugs that have shown lifespan extension, healthspan expansion in mice. The issue is that you cant develop a drug for people today for a purely logistical standpoint. Right . Like, if i gave you an ageing drug, it would be decades before i would know if you develop age related diseases and decades before ifind out, you know, your eventual lifespan. So dogs have similar diets to us, they live in the same environment and they also develop the same age related diseases as we do, at approximately the same kind of in our lifespan. So if a drug works in a dog, its not i to i to work in a human, but its much more likely versus, we do a lot of research on mice and that doesnt translate at all. Back to humans, and if we want to reduce the age that our bodies seems, rather than is, well, we need to find a way to measure it. I was really put through my paces with this test, assessing my baseline, then pushing me to my physical limit. Was this really necessary . Really nicejob. You got this good job. What a relief to take that off ive recovered, so how fit am i . You did a really nicejob, nice test. At least i discovered at the end that i have a fitness age of 36, thats seven years lower than my years. But there is an easier way a few drops of blood and this scientists invention known as the Epigenetic Clock can assess my biological age and possibly the date of my demise. There is this grim age which is our best Mortality Predictor and, unfortunately, you are a little bit older than you should be. It says 49 years. Thats unfortunate its very important to have a sense of humour when one looks at these reports. What about death . I could come up with a date almost predicting when you would die. When do you think its going to occur, according to this . We dont give people this. But you know, you know the answer to that question . I have a way to calculate it. Can you tell me . No, i wont, and the reason is things change, you know, people develop Healthy Habits or bad habits, bad luck, so its essentially not very informative for you. You cant even tell me the likelihood of which illness it is, it is just that my body is ageing a bit faster . Yes. I dont want to go back to this, but a bit deflated. The question is really, why . We have a lot of good news for you. I wanted to start with the bad news. Look at that, your female age is 36. 5, seven years younger than expected. Right, my biological age is 36, my chronological age is 43, and my disease risk is a lot higher than it should be. Hmm. I wont worry too much, though, its very early days for these tests. How about this one . Infact, im keeping my spirits up and im off to a longevity meet up. So are these brainy scientists living the Longevity Lifestyle . Well, there are still unopened bottles of wine, so probably tonight, we had a longevity friendly mix of food, seaweed and fish. Other parts of the industry havent been quite so wholesome, though. For decades, theres been a lot of snake oil, a lot of miracle pills, the god pill, all of this stuff. And many have been desperate to believe just ask this leading Silicon Valley doctor. I dont know why people want to gamble with their health. I understand gambling with money, so if its safe and not effective like a vitamin, some vitamins. Then youre gambling with your money. But if its not proven safe, and its not proven effective, youare gambling with your health, and then there are people spending a lot of time doing these things and they are not living their life, they are living the version of their life to give themselves a future life, but what happens if the future life never materialises . The repurposing of current drugs might hold some promise to preventing age related disease and some dont even want to wait for the Clinical Trials. Especially in Silicon Valley amongst techies, its hard to find somebody who isnt taking metformin this diabetic drug that these people arent diabetics and theyre typically quite healthy, but theyve seen some of the studies and even though it hasnt been approved as an anti ageing drug, they are taking it. The same with others, so you have a lot of people who are going off book, going doctor shopping, looking for those doctors that will give them the pills that might be for something else, but have shown an effect on extending life in animals. I get asked by young men in their 405, should i take metformin . And my first question is, are you ready to lose half of your testosterone . There are no medicines without side effects. The good news is with all these blood tests, breath tests, urine tests, wearables, apps, there are so many things that track things. So if you really want to, like, if you are overweight and have high blood pressure, and you love your wine and your life, but you want a pill to make you live long, guess what . You cannot stop the wind with your hands. Its probably getting close to this lot� s bedtime, and they really value sleep. I want to wake up naturally, because your cortisol levels, which is your Stress Hormones go down as you sleep and right up when you wake up a spike. A lack of good sleep can disrupt them and in turn lead to unnecessary inflammation and a higher risk of disease. Its like inflammation, so you want to do everything you can to decrease the inflation in your body. The pills and supplements and the cryo and all this stuff, they tout that it does that, but show me the measurements outside of people saying, ifeel better. Because by the way, placebo, people feel better. And im not saying that is placebo because there is lots of interesting science in there. Whether pills or procedures are proven or not, there are a whole lot of people who are really obsessed. Some of this stuff, does it seem a bit cult like, this stuff . Very cult like and i try to protect my people against that cult aspect. We try not to let it become that way. There is one issue that none of this can resolve, though. In the united states, the single biggest determiner of your Life Expectancy is your postcode, where you live. So that is a problem that cannot be engineered. Once drugs are developed, will they not further enhance the inequality, because whos going to get access to the drugs and when . The model, the way it works, the drugs become available and if they actually are demonstrated to be valuable, they become available to insurance companies, and we expect the same thing to happen with all drugs that will be developed together. So where does this leave us . Theres exercise, but. Exercise is hard, magic pills are easy. One gives us an extra six months, another gets a year, and you piece this together and we are living to the age of 85, 95, healthily. Will the drugs come . There are a ton of companies who are trying to capitalise on this enthusiasm, raising a lot of money, but then you get to the very hard yards of actually science, bench science, putting something in a human body and actually having it work. And there are bigger questions over how we may need to work longer, the unexpected diseases that will emerge at these older ages, and our planet is already pretty busy. First thing to consider is these changes that were talking about are not going to happen tomorrow, theyre going to be happening slowly, the same way weve doubled our lifespan over the past 150 years, and we slowly adapted. As for bryan. What has the reaction been from doctors and scientists to what youre doing, because i guess itas been because i guess its been kind of mixed . The reaction has been very mixed. There are quite a few people who are excited that this is happening and its a good blueprint for them. Theres also been a colossal amount of hate, which i love. I love every bit of it. I think bryan is a true pioneer. Is there not a bit of a risk in what hes doing to himself . There is a concern, we will see what happens to him in the long term. So far, his numbers look good, he claims to be extremely happy, i think its an interesting experiment for us to watch. Ooh, delicious the reality is that we know a lot about the science of ageing. Squeeze, squeeze, squeeze. But the Big Scientific Breakthroughs just arent there yet, so i guess i come away from this feeling more than ever that its so important to live your healthiest life, just maybe not quite to the extent of bryanjohnson. Lucky us, we exist. Lets play the most fun games we can, for as long as we can. Hello there. Good afternoon. Well, its still blustery for this time of year, but the keen South Westerly Wind is falling a little lighter for most areas than it was yesterday. Another day of sunshine and showers. Shower clouds building here in clacton on sea, in essex. And a lot of sunshine recorded by our Weather Watcher in east lothian. So the general theme is just set to continue. But the showers will be less heavy, less frequent for most places than we saw yesterday. Still some sharp and thundery showers, though, always possible close to that centre of low pressure out towards the north of scotland. Theres another system, too, approaching from the south west by the time we get to the end of the day. So it will cloud over by the end of the afternoon across pembrokeshire and parts of cornwall. The showers will gradually fade away through parts of england as we head through the afternoon. Some brightness out towards eastern areas of england will help to lift the temperature to 23 or 2a degrees. Cloudy across western scotland. A rumble or two of thunder always possible across the moray firth. And then overnight tonight, this rather large area of rain isjust going to be pushing its way further northwards and eastwards across central and southern england, and into northern england, too. Certainly very wet across wales tonight. Mild and muggy underneath that rain. Clear spells across Northern Ireland. And for scotland, watch out for a few showers still. Now, that rain continues to push further northwards and eastwards through the day on monday. Its a rather messy area of rainfall, a lot of uncertainty still on the timing of the clearance of it. There are localised met Office Weather warnings in force for heavy rain across wales and for much of northern england, East And West of the pennines. Rainfall totals of around 30 to a0 millimetres, but higher than that with any embedded thunderstorms. Brightness developing later on through the day across wales and south west england. Warmest out towards eastern areas of england, with some brightness here. We should see sunshine and showers across much of Northern Ireland and scotland on monday, so a quieter looking day here. It will be windy in the south, but the winds ease down considerably on tuesday, so a much quieter day of weather. That system has now pushed off into scandinavia. There could be a few showers breaking out through the afternoon, but also some sunshine on tuesday, with temperatures rising for most areas into the low 20s in celsius. And then we start to see High Pressure building in from the south, so towards the South Of England and south wales, temperatures could rise into the mid 20s in celsius. Always a little cooler, a bit more showery towards the north and west, but still some sunshine here. Live from london. This is bbc news. A warning of a significant rise in the death toll from hawaiis devastating wildfires. 93 people are confirmed dead so far. When we find these, you know, ourfamily and ourfriends, the remains we are finding is through a fire that melted metal. The British Government is under renewed pressure to stop migrants crossing the sea in small boats after six people drowned in the channel. And a look atjust how much streaming platforms like netflix know about us in the quest to recommend the perfect show. Hello. We start in hawaii, where the governor is warning that the death toll is likely to rise still further following the wildfires on the island of maui. 93 people are now known to have died as the inferno burnt most of the Historic Town of lahaina to the ground. So far only a tiny fraction of the worst hit area has been searched for bodies. More than 2,200 structures homes and businesses have been damaged or destroyed. Recovery crews continue to comb through the charred ruins and hundreds of people remain unaccounted for. The wildfires are the worst to hit a state in america in over
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