the longevity industry is worth billions, with hopes of delaying disease, extending our sprightly years and maybe even throwing in a few extra. i let a system of science and data run my body. it does a betterjob taking care of me than i can. maybe even our furry friends can be with us for longer. he sneezed in my face. and the things some people will do to stay young! you got this. do you consider yourself a guinea pig? laughs. no, i do not. i consider myself to be an explorer on the frontiers, trying to find out what is possible. tech entrepreneur bryanjohnson is spending millions trying to turn back time on his body. i refer to myself as a professional rejuvenation athlete. it's a new sport i want to create. i'm not a bio—hacker, i'm not a health enthusiast, i am a professional rejuvenation athlete. i love it. working with a team of 30 scientists, his daily life is dictated by an extreme regime of fitness, diet, tablets, tracking and treatments. i am chronologically 45 years old, biologically i am a few hundred ages. my left ear is 64. my fitness tests say i'm 18. my heart is 37. my diaphragm strength is 18. and i playfully say i am trying to become like an 18—year—old. my son is 17 so i always tease him and say, "when i grow younger, i want to be like you". where is he taking me? wow. where to start in here! what is this? this is a high frequency electromagnetic stimulation. we got this machine because we were trying to solve a problem. every night i was getting up one time per night to go to the bathroom. and when i do so, that is actually normal — but when i did so, it produced less quality sleep. so, i wanted to see if i could get up zero times, so we got this machine to trial could we strengthen my pelvic floor and my bladder so i wouldn't get up at night to go to the bathroom. do you want to try it out? do you want to just sit down? 0k — is it going to vibrate or something? it's actually, a lot of women use this after having babies to rebuild the strength of the pelvic floor. a lot of women use kegel exercises. this is basically kegel stimulation. right. i'm going to turn it on, and the feeling is going to be a little foreign, and it might be shocking initially. 0k. oh, it's like pins and needles. it is sort of tickling, but tickling in a quite hard and aggressive way. how long do you do it for? the session is 30 minutes. but actually it has been successful. is this one of those devices that measures the age of your skin? that's right. how's yours doing? we have made about 22 years of progress in reversing the age of my skin. it takes all these images of yourface, and you get about ten reports on pore size, uv spots, reds, browns. your skin is amazing. is this just from your regime or is there other help? other help too, we have some lasers over there. there's no injections — that's just from everything in here? that's right. what do we have next? this is something that also tells you the health of your cardiovascular system, so your age. it looks at advanced glycinated product in your skin. if you want to try it, you can put your arm on it and it will tell you your age. ideal score would be around two. right — so i am only a little bit too old for my age, it could be worse. what's next? ok, this is an ultrasound machine, medical grade. this is what you'd see in a hospital. are you having a baby? laughs who knows, with what you're getting up to already! what are you actually using it for? we look at the brain, the lungs, the heart, the pancreas, the prostate, tendons, ligaments, everything, it is really a useful technology to have in the clinic to do on a routine basis. how do you feeljust before you do any of this tracking? do you get a bit nervous, hopeful? do you have expectations? it is a game. some of my most happiest days are when we do these full measurement days. what's your motivation? are you doing this for yourself or for humanity? when i was 21 years old, i decided that i wanted to spend my life doing something meaningful for the world. and i didn't know what to do so i said, i'm going to make a whole bunch of money being an entrepreneur by the age of 30, then i'll decide what to do. since i sold my company, braintree venmo, i made $300 million and the question was, what could i do that would matter in the year 2500 and right now it could be ageing. if we slowed the speed of ageing and even reversed it, it would change what it means to be human. do you think you are risking your health here? in all the things you're doing to protect it, do you think there's also some real risk? certainly, there is always risks. but there is potentially an argument that we are being more safe than anyone else because we have the rigour of measurement. whilst bryan signed his life away to experimentation, i visit the buck — the world's first institute for ageing research. these scientists are working on drugs that they hope could delay age—related disease. here i have two of my postdocs, jorge and genesis... would you say there has been huge scientific advancement in this field recently or is there just a sudden trend for investment and interest in it? the science has matured in terms of, we have been doing this for close to 30 years, understanding the basic mechanism of ageing, number one. number two, the societal needs are there, you have a rapidly ageing population with an increasing burden of chronic diseases. this place is huge. this is one of about 20 labs. three, two, one, squeeze. it's notjust drugs and supplements being put through their paces here though, it's also exercise. what kind of exercise, how much, how often, aerobics, anaerobic, lifting weight, yoga, balance, swimming — which one of these interventions actually works the best? but one really important discovery in mice here was the ability to reduce what are called senescent cells. these zombie cells play a useful role throughout our lifetime but as we age, we acquire many more, and as they also lead to inflammation, that increased number ends up providing a hotbed for cancer and all sorts of disease. so biotech companies are trying to create drugs that will reduce that cellular senescence. i'm adding my reagent to the eye tissue so i can understand which types of cells are senescent. unity is using this science, and it has now achieved small early—stage clinical trials for eye injections to treat macular degeneration — that is failing eyesight that glasses can't fix. we stain senescent cells purple so i can visualise spatially within the eye where the senescent cells reside. once you get rid of one of these cells, it is gone. this would be a small number of treatments over a limited amount of time. one of the things we started to see is because the fda won't approve drugs just for anti—ageing, companies are looking for a specific problem to treat. alzheimer's disease is an important one, cardiovascular diseases, kidney diseases, liver diseases — all of these are diseases that are more prevalent as we get older, and to the extent that they have a basis of cellular senescence, these agents we are working on could have applicability in other diseases. what have you got here? that looks like it is connected to an eye? yeah, we get normal eyes and diseased eyes. we can section the eye, a cross—section of it very thinly and put it on a microscope slide. here we are testing different drug candidates on our animal models. so we test in a diseased animal model, does our drug actually inhibit the neovascularisation from forming or get rid of it once it is already formed? a lot of mouse trials have not translated well into humans? we believe it translates relatively well compared to a tumour of cells, and a tumour in a human. quite creepy when you know what it is. yeah, i think it is quite cool. but maybe we are missing something. lifestyle is responsible for about 93% of your longevity. only about 7% on your genetics so you can't blame your parents. a lot of exercise, some fasting, a lot of good sleep, a lot of social connection, very little alcohol, try to spend at least 14 hours of your 24—hour day without ingesting any calories. this has profound effects on your metabolism, on many of the pathways. based on the data, i would predict that most people could live to 95 in good health if they did all of the things that we know would promote a healthy lifespan. if they work, why do we need to deal with this bigger picture? senescence is still going to happen. hopefully if you exercise, its going to be delayed by 10, 15, 20 years. i don't mean to be saying that lifestyle intervention is all that needs to be done, there is a need for science for the future. what is that thing that people do where they sit on the floor and try to get up without using their hands? whatever eric has been doing seems to be working. this is meant to be some sort of sign of youth, if you can stand up by not using your hands... how can anyone do that, pushing yourfeet down, how is that possible? how do you do that? i don't know. i think it means you are under 20 or something. exactly. i can't do it! 0ur furry friends could get their paws on a life extending pill first though. # i love my dog to bits... you'll notice there are no great danes here, there are no large dogs here, and it's because they can have a lifespan of six, seven, eight, nine years, almost half of what a little guy like this could be expected to have. our hypothesis is that the short lifespan of big dogs is a disease. # he's my honey, sweetie, sugar canine number one pal... we are a senior dog rescue, and when we take in dogs, like a great dane for instance, at five years old, they are already starting to age so much, and it would be like a miracle cure if we could have some of our big dogs live longer and live as long as the small dogs. ms robinson, that's for you. where are you at now with the trial? we are kicking off our big, pivotalstudy, we are trying to understand, does our drug extend life span and quality of life? it's a preventative drug, inhibiting the protein that we believe drives big dogs to age fast. and if everything goes to plan we will hopefully have a drug on market in 2025. if successful, this drug could hasten the solution for humans as well. has there been any sort of scientific breakthrough that has made possible what you are trying to do? yeah, the thing that people don't realise is there have been hundreds of drugs that have shown lifespan extension, health span expansion in mice. the issue is you can't develop a drug for people today from just a purely logistical standpoint. if i gave you an ageing drug, it would be decades before i would know if you develop age—related diseases, and decades before i find out your eventual lifespan. dogs eat similar diets to us, they live in the same environment and they also develop the same age—related diseases as we do, at approximately at the same time in our lifespan, so if a drug works in a dog, it is not i—to—i to human but it's much more likely versus, we do a lot of research on mice and that does not translate out all. back to humans, and if we want to reduce the age that our bodies seems rather than is, well, we need to find a way to measure it. i was really put through my paces with this test, assessing my baseline, then pushing me to my physical limits. was this really necessary? really nicejob. you got this! good job. what a relief to take that off! i've recovered so how fit am i? you've done a really nicejob, nice test. at least i discovered at the end that i have a fitness age of 36, that's seven years lower than my years. but there is an easier way — a few drops of blood and this scientist's invention, known as the epigenetic clock, can assess my biological age and possibly the date of my demise. there is this grim age which is our best mortality predictor and unfortunately you are a little bit older than you should be. it says 49 years. that's unfortunate! it's very important to have a sense of humour when one looks at these reports. i could come up with a date almost predicting when you would die. when do you think it is going to occur, according to this? we don't give people this. but you know, you know the answer to that question? i have a way to calculate it. tell me! no, i won't, and the reason is things change, you know, people develop healthy habits or bad habits, bad luck, so it's essentially not very informative for you. you can't even tell me the likelihood of which illness it is, it is just that my body is ageing a bit faster? i don't want to go back to this, but it's a bit concerning. the question is really why. we have a lot of good news for you. i wanted to start with the bad news. look at that, your female age is 36.5, seven years younger than expected. right, my biological age is 36, my chronological age is 43, and my disease risk is a lot higher than it should be... i won't worry too much though, it's very early days for these tests. how about this one? in fact, i'm keeping my spirits up and i'm off to a longevity meet up. are these brainy scientists living the longevity lifestyle? there are still unopened bottles of wine, so probably! tonight we had a longevity friendly mix of food, seaweed and so on. other parts of the industry have not been quite so wholesome though. in four decades there has been a lot of snake oil, a lot of miracle pills, the god pill, all of this stuff. many have been desperate to believe, just ask this leading silicon valley doctor. i don't know why people want to gamble with their health. i understand gambling with money, if it is safe and not effective like a vitamin, some vitamins, then you are gambling with your money but if it is not proven safe, and it is not proven effective you are gambling with your health, and then there are people spending a lot of time doing these things and they are not living their life, they are living the version of their life to give themselves a future life, but what happens if the future life never materialises? the repurposing of current drugs might hold some promise to preventing age—related disease and some don't even want to wait for the clinical trials. especially in silicon valley amongst techies, it's hard to find somebody who isn't taking metformin, this diabetic drug that these people are not diabetics and they are typically quite healthy, but they have seen some of the studies and even though it has not been approved as an anti—ageing drug, they are taking it, the same with others, so you have a lot of people who are going off book, going doctor shopping, looking for those doctors that will give them the pills that might be for something else but have shown an effect on extending life in animals. i get asked by young men in their 405, should i take metformin. and my first question is are you ready to lose half of your testosterone? there are no medicines without side effects. the good news is with all these blood tests, breath tests, urine tests, wearables, apps, there are so many things that track things so if you really want to, like if you are overweight and have high blood pressure, and you love your wine and your life, but you want appealed to make you live long, guess what? you cannot stop the wind with your hands. it's probably getting close to this last bedtime, they really value sleep. i want to wake up naturally, because your cortisol levels, which is your stress hormones go down as you sleep and right up when you wake up they spike. so a lack of good sleep can disrupt them and in turn lead to unnecessary inflammation and a higher risk of disease. it's like ageing, so you want to do everything you can to decrease the inflation in your body. the pills and supplements and the cryo and all this stuff, they tout that it does that, but show me the measurements outside of people saying i feel better. because by the way, placebo, people feel better and i'm not saying that is placebo because there is lots of interesting science in there. whether pills or procedures are proven or not, there are a whole lot of people who are really obsessed. some of this stuff seems a bit cult like, this stuff. very cult like and i try to protect my people against that cult aspect. we try not to let it become that way. there is one issue that none of this can resolve though. in the united states, the single biggest determiner of your life expectancy is your postcode, where you live. that is a problem that cannot be engineered. 0nce drugs are developed, will they not further enhance the inequality, because who was going to get access the drugs and when? the model, the way it works, the drugs become valuable if they actually are demonstrated to be valuable to insurance companies, and we expect the same thing to happen with all drugs that will be developed together. so where does this leave us? there is exercise, but... exercise�*s hard, magic pills are easy. one a six months, another gets a year, and you piece this together and we are living to the age of 85, 95, healthily. will the drugs come? there are a ton of companies who are trying to capitalise on this enthusiasm, raising a lot of money, but then you get to the very hard yards of actually science, bench science, putting something in a human body and actually having at work. and there are bigger questions over how we may need to work longer, the unexpected diseases that will emerge at these older ages, and our planet is already pretty busy. first thing to consider is these changes we are talking about are not going to happen tomorrow, they are going to be happening slowly, the same way we have doubled our lifespan over the past 150 years, and we slowly adapted. as for brian... what has the reaction been from doctors and scientists to what you are doing, because i guess it has been kind of mixed? the reaction has been very mixed. there are quite a few people who are excited that this is happening and it's a good blueprint for them. there has also been a colossal amount of hate, which i love. i love every bit of it. i think brian is a true pioneer. is there not a bit of a risk in what he is doing to himself. there is a concern, we will see what happens to him in the long—term. so his numbers look good, he claims to be extremely happy, it's an interesting experiment for us to watch. delicious! the reality is we know a lot about the science of ageing. squeeze, squeeze, squeeze. but the big scientific breakthroughs are just are not there yet, so i guess i come away from this feeling more than ever that it is so important to live your healthiest life, just maybe not quite to the extent of brian johnson. lucky us, we exist. let's play the most fun games we can for as long as we can. hello, i'm dealing with the capture. tonight, all things football, bsl signs and doctor. first, it's a big weekend for football, the premier league kicking off with manchester city up against burnley, and don't forget the women's world cup, england are gearing up to face columbia on saturday's quarter—finals, looking to draw against sweden and spain in the semifinals but they will be without lauren james semifinals but they will be without laurenjames after her two match band. some other stories now, rishi sunak is racking up frequent flyer miles with the raf, new data showing he is taking more domestic flights on governmentjust in helicopters than the last three prime ministers, making almost one flight per week in his first seven months as prime minister. tori lane says he doesn't need to apologise after he was sentenced to ten years in prison for shooting her in the foot in 2020. a little bit of good news for people who use sign language. 200 environmental science students now have their own sign, including pollution, acidification and carbon footprint, meaning teachers and scientists might have to spell out each letter for those words, and it will be easier for deaf people to take part in discussions on climate change. finally, i believe you were ten seconds of docs. forget the premier league because the world's largest festival is happening in the east midlands with thousands of dogs, just like that one, taking part. that it from me, you are all caught up. hello. it is shaping up to be yet another unsettled weekend of weather but that doesn't mean it's going to be raining all the time — far from it. while it will be showery and quite breezy, there'll be some drier spells, too. in fact, parts of the south and the east are going to see the driest of the weather, furthest away from the centre of this area of low pressure. that is what will be driving the showers over the weekend. and see all the white lines, the isobars squeezing together? that shows that we are going to have some quite brisk winds, particularly around western coasts. a band of rain through the morning pushing its way northwards and eastwards across scotland. northern england seeing some of that, maybe parts of wales. behind that, sunny spells and showers, some of them heavy and thundery. a few showers breaking out down towards the south—east corner but actually, a decent amount of dry weather to be had here. so, there's confirmation of what will be a breezy, indeed quite windy day around some western coasts. temperatures a little down on where they have been. the warmest weather in eastern england at 2a degrees, more generally around 16 to 22. and then, as we head through saturday evening, we'll continue to see some showers, particularly across the north and the west of the uk. some areas of cloud, some clear spells, too, and another relatively warm night — 12 to 15 degrees. so, for sunday, our area of low pressure just continues to swirl, centred close to the north—west of scotland, so that will be driving the showers. this frontal system here to the south—west, that'll be running in later in the day. so, some spells of sunshine to be had but also some showers, maybe some longer spells of rain at times for northern ireland and western parts of scotland. and then, late in the day, some cloud and perhaps some rain into the far south—west of england, maybe the far south—west of wales. temperatures between 18 and 23 degrees. breezy again — perhaps not quite as windy as on saturday. now, through the coming week, low pressure will be with us initially but then, it looks like high pressure will build for a time and, actually, as that high shifts eastwards, it may be that we start to pick up a feed of slightly warmer air from the near continent. the big question mark is about how quickly this area of low pressure then swirls in from the west to turn things unsettled once again. but signs are that as we head through the coming week, there will at least be some drier and warmer weather on the way for many of us. live from washington, this is bbc news. the death toll from the hawaii wildfires rises again, amid questions about whether alert systems failed to warn residents. the usjustice department names a special prosecutor in the hunter biden inquiry. plus, a well—known mountaineer denies accusations her team climbed over an injured guide during a bid to break a world record. hello, i'm carl nasman, thanks forjoining us. the number of people killed by wildfires on the hawaiian island of maui has risen to at least 67. that makes it officially the us state's deadliest ever natural disaster. these are pictures from the all—but—destroyed town of la haina. structures completely levelled, nearly nothing left. the fire that ripped through here still hasn't been fully contained. residents are now for the first time being allowed to return, if it's safe — but they won't be able to stay, with a curfew coming into force at 10pm local time. meanwhile, hawaii governorjosh green says he's ordering