At half past eight. The uk now has its third coronavirus vaccine. The first doses of the Moderna Vaccine have been given in wales and scotland with a 24 year old carer the first to receive it. Police in california say the golfer, tiger woods, was driving at nearly double the speed limit before a crash that left him seriously injured. A gambler who was denied a £1. 7 millionjackpot over an alleged Software Glitch wins his legal Battle Against Betfred to claim the playout, plus interest. And a team of scientists based in the United States say theyve found strong evidence for the existence of a new force of nature. Good evening and welcome. The uks Top Health Experts have issued new guidance on the roll out of the Oxford Astrazeneca vaccine. It follows growing evidence that in extremely rare cases people whove had the jab have developed blood clots. So what is the new guidance . People aged between 18 and 29 will be offered an alternative to the Astrazeneca Jab. Those whove already had a first dose of the astrazeneca vaccine should go ahead and get the second. Pregnant women and people with certain Blood Disorders should consult a doctor before taking the jab. The head of the medical regulator insisted that the benefits of taking the Astrazeneca Jab still far outweigh the risks for the vast majority of people. Our medical editor fergus walsh looks at the evidence that has led to todays changes. Turn up, get yourjab. The message remains the same. But in future for the first time, the Covid Vaccine you receive will depend on your age. Thats because evidence is emerging of a link between the Oxford Astrazeneca vaccine and very rare blood clots. The uk regulator the mhra said up to the end of march there have been 79 cases of rare clubs with low platelets following a first dose of the astrazeneca vaccine. 19 people have died. Thats out of 20 million who received the jab. Thats one rare clot in every 250,000 vaccinations. A79 a 79 cases of rare clots. These Monitoring Systems are now detecting a potential side effect of the covid 19 vaccine astrazeneca, in an extremely small number of people. The evidence is firming up. The balance of benefits and known risks of the vaccine is still very favourable for the vast majority of people. Very few adults under 30 have died from covid, so that changes the Risk Benefit Balance from getting a vaccine. Its thought younger adults are at higher risk from gods after the Astrazeneca Jab. From clots. About one in every 100,000 doses. So they will be offered a different vaccine when their time comes. Are you worried that this change of course might damage vaccine confidence, especially in the young . These are really carefully considered decisions, and it remains vitally important that people who are called back for their second dose come for it and it remains vitally important that all adults in the uk come forward for vaccination when they are offered at. The European Medicines Agency has come to the same conclusion there is a possible link between the astrazeneca vaccine and very rare blood clots. Mostly in women under 60. Several eu countries had already restricted the astrazeneca vaccine to older adults. France to those over 55. Germany to those over 60. Scientists who analyse risk say this change of course should not put people off getting a vaccine. This vaccine is extraordinarily effective and it would be tragic if this led to distrust of this vaccine, even worse if it was for vaccines in general for covid because it has been shown to be amazingly effective. Its saved thousands of lives already. The Prime Minister believes the path to lifting restrictions should not be disrupted. I dont see any reason at this stage at all to think we need to deviate from the road map, and we are also very secure about our supply. Its thought Covid Vaccines have already prevented 6000 deaths in the uk, and they remain the key to ending lockdown and returning life to normal. Fergus walsh, bbc news. In the past hour Oxford University has made a statement regarding the change in advice. Professor andrew pollard, director of the Oxford Vaccine Group said. The identification of rare cases of blood clots, which might be associated with the vaccine, shows that the Safety System works, and has also allowed mhra and ema to conclude that the benefits of vaccination continue to outweigh the risks, while putting in measures to help mitigate any possible risk. The pandemic coronavirus continues to be a huge threat to people throughout the world, and we continue with our mission to support global vaccination, not for profit, for the benefit of humanity. That statement coming in just within the past hour. Ever since the first reports of blood clots being associated with the Astrazeneca Jab thereve been questions about what it means for the uks Vaccine Programme and peoples attitudes to it. 0ur Health Editor hugh pym looks at some of the issues that have been raised. Lockdown is easing, the Vaccination Programme is going well. But today there has been a change of course, raising new questions. First, what is the risk with Oxford Astrazeneca . It is lower the older you are, as the potential for serious illness with covid is weighed against potential harms from blood clots. The official advice is that anyone who has had a firstjab and four days or more after that gets severe headaches, blurred vision or certain other symptoms, should contact a medical professional. A committee of europes regulator, known as prac, drew this conclusion. We know the benefits of the astrazeneca vaccine have been established. It prevents covid disease, it prevents hospitalisation and it prevents mortality. So in that respect, prac feels that the overall benefits outweigh the risks. So will it delay the vaccine roll out . Health Officials Say even with under 30s given a choice of alternative jabs, theyre still on course to offer all adults a first dose by the end ofjuly. So the road map should stay the same. Although it does depend on supplies currently promised. Of the vaccines currently in use, the government ordered 100 million doses from Oxford Astrazeneca. Though the roll out will slow down this month because of supply issues. From pfizer biontech, it was a0 million. And from moderna, 17 million doses, there are only a limited amount will come through this month. Two more vaccines are being assessed by the regulator, the mhra. Novavax, where there are 60 million doses on order, and janssen, 30 million doses. Trials are ongoing with other vaccines where the government has made preliminary orders. So will confidence in the Oxford Astrazeneca vaccine be affected . People in younger age groups we spoke to had varying opinions. I am a bit concerned to hear it because im 2a and ive already had my first dose of the astrazeneca vaccine. And i have my second dose booked in for a couple of weeks. Its one of those very rare cases. It might happen, but it probably wont. The risk is probably, its probably worth the risk, right . Im still all for it. Im going to do a little bit more research now into it, but i still think at this point i would get the astrazeneca vaccine. Officials say the benefits outweigh the risks for the vast majority of adults. It remains to be seen how people react. Hugh pym, bbc news. We will be answering more of your questions at 8 30pm right here on bbc news right here about the Oxford Astrazeneca vaccine, so send any questions you have using the hashtag bbc your questions where you can also e mail your questions and put into our experts. A young carer from carmathenshire has become the first person in the uk to receive the moderna coronavirus vaccine. The government has ordered 17 million doses of the jab which is the third to be offered in britain. About Five Thousand doses are being distributed across west wales, and another batch is being administered from a Vaccination Centre in glasgow. Heres our correspondent, huw thomas. A new weapon in the fight against coronavirus. 24 year old ella taylor was the first person in the uk to get them a during a vaccine in wales. Thousands of doses will be administered here beginning with unpaid carers. Trier . Administered here beginning with unpaid cerem unpaid carers. Very excited, very ha. L unpaid carers. Very excited, very happy. Thrilled. Unpaid carers. Very excited, very happy, thrilled. Why unpaid carers. Very excited, very happy, thrilled. Why are unpaid carers. Very excited, very happy, thrilled. Why are you unpaid carers. Very excited, very happy, thrilled. Why are you so l unpaid carers. Very excited, very happy, thrilled. Why are you so keen to net it . I happy, thrilled. Why are you so keen to get it . I am happy, thrilled. Why are you so keen to get it . I am going happy, thrilled. Why are you so keen to get it . I am going to happy, thrilled. Why are you so keen to get it . I am going to take happy, thrilled. Why are you so keen to get it . I am going to take care to get it . I am going to take care of my grandmother to get it . I am going to take care of my grandmother so to get it . I am going to take care of my grandmother so it to get it . I am going to take care of my grandmother so it is to get it . I am going to take care of my grandmother so it is very l of my grandmother so it is very important to me that i can get it and take care for and probably be safe. , and take care for and probably be safe. ,. , safe. Vaccines offer personal protection safe. Vaccines offer personal protection to safe. Vaccines offer personal protection to those safe. Vaccines offer personal protection to those who safe. Vaccines offer personal protection to those who have safe. Vaccines offer personal protection to those who have had them and they are part of the Exit Strategy from the pandemic. As with the other two vaccines being used in wales, the modernityjab needs two doses to be given to be most effective and the first is been received. It effective and the first is been received. ,. , , effective and the first is been received. ,. , received. It is massively important, ust to received. It is massively important, just to illustrate received. It is massively important, just to illustrate how received. It is massively important, just to illustrate how normal received. It is massively important, | just to illustrate how normal people like me just to illustrate how normal people like me can just to illustrate how normal people like me can have the vaccine, especiaiiy like me can have the vaccine, especially being the first it is a bit worrying i suppose for a lot of people bit worrying i suppose for a lot of people but seeing people like me having people but seeing people like me having it people but seeing people like me having it surely is going to give some having it surely is going to give some confidence to other people to come some confidence to other people to come forward. Come forward. Vaccine, vaccine, vaccine. The mauenta vaccine, vaccine, vaccine. The Magenta Vaccine vaccine, vaccine, vaccine. The Magenta Vaccine has vaccine, vaccine, vaccine. Magenta vaccine has big support vaccine, vaccine, vaccine. Magenta vaccine has big support is not least the singer dolly parton, she helped to fund its development and had her van she helped to fund its development and had hervan x she helped to fund its development and had her van x that help fund it last month that make if i was a familiar format given in two doses several weeks apart and like the fisa vaccine, the Magenta Vaccine are based on rna part of the Virus Protection and code. 0nce injected its team mates and immune response which means the body will be ready to fight the virus and future. The uk government which is managing the Vaccine Programme has bought 17 million doses with the first 5000 doses now being administered in west wales. 0n doses now being administered in west wales. On another doses now being administered in west wales. 0n anotherfront, more Ace Sentiment of testing is happening prince of wales, a second phase of Community Testing began in bridgend today aimed at people aged 11 and over who are not showing symptoms of the virus, designed to stop the unwitting spread of covid 19 between Family Members and work colleagues. Vaccinating carers will help protect the most vulnerable. The arrival of the most vulnerable. The arrival of the Magenta Vaccine is another tool to tackle a pandemic that still has a tight grip on all of our lives. Brazil has recorded more than 4,000 covid related deaths in 2a hours for the first time, as a more contagious variant of the virus fuels a surge in cases. Hospitals are overcrowded and the Health System is on the brink of collapse in many areas. 0ur Science Editor David Shukman reports. Even at night, the graveyards in brazil are busy. So huge are the losses from covid. And although the rate of deaths, given the size of the population, is not quite as bad as in the uk or italy, things are getting worse and medical staff are desperate that even now the message still isnt getting through. It is quite hard to understand the need for social distancing when you have a president that says that social distancing is bad. President Jair Bolsonaro is getting a lot of the blame. From the start he has played down the virus and he keeps blocking local authorities from taking any action, so the disease is now out of control. A big concern is a new variant, known as p1, which has now spread fast. The result is this, depressing picture of the rapid rise in the number of coronavirus deaths in brazil, with more than 1,000 in brazil with more than 1,000 in the last 2a hours. More than 4000. Behind much of this is that p1 variant which compared to others is more transmissible and seems to affect more younger people. Though it is thought the vaccines should still be effective against it. In any event the variant has spread to most of south america, including uruguay, peru and bolivia which hasjust closed its border with brazil and its got further british colombia is dealing with hundreds of cases and there are four smaller numbers as far afield as japan, turkey, the uk and many other countries. And although vaccines are being given in brazil, they have reached only 8 of people and the fear is that the more infections there are anywhere in the world, the greater the chance for new, more challenging variants to emerge. David shukman, bbc news. The headlines on bbc news. People under the age of 30 in the uk are to be offered an alternative to the astrazeneca Covid Vaccine, because of evidence linking it to extremely rare blood clots in a very small number of cases. The eu Drug Regulator also updated its guidance, concluding that unusual blood clots should be listed as a very rare side effect. The uk now has its third coronavirus vaccine. The first doses of the Moderna Vaccine have been given in wales and scotland with a 24 year old carer the first to receive it. For the full round up of all The Sports News began can cross over to the bbc� s sport centre to join austin for some good evening austin. Good evening, were going to start with football because the first legs of the last two Champions League quarterfinals have just got under way. And chelsea are in action away at fc porto. Currently goalless there. But in a repeat of last years final, reigning champions Bayern Munich are already 1 0 down against Paris St Germain in germany, Kylian Mbappe with the early goal. You can follow all the latest on the bbc sports website. Now, liverpool say racist abuse on social media cannot be allowed to continue after their players Trent Alexander arnold and naby keita were targeted. Both had racist emojis sent to them on instagram in the lead up to tuesdays Champions League tie with real madrid. In a statement, the club said. Saying that it was utterly unacceptable. The club will work with the relevant authorities to try to identify and prosecute offenders and added that it. Well, ahead of Arsenals Europa League match against Slavia Prague tomorrow, Midfielder Willian had his say on the online racial abuse. We report it. We share it with you guys and we speak about that, but we want action, you know . We dont see any action, you know, from the authorities in that case, you know . And, yeah, i think we have to try better a way to stop it. Staying with football, theres good news for fans in scotland, because the Scottish Government has given approval for 12,000 supporters to attend euro 2020 matches at hampden injune. So that would be 25 of the stadiums capacity. 0rganisers Uefa had given the 12 host cities until today to submit plans for Fan Attendance with venues likely to be changed if assurances werent be given. Werent given. Hampdens set to host four games, starting with scotlands opener against the czech republic. But dublins participation is in doubt after the Irish Government failed to give assurances. Assurances over the aviva stadium. The final of the World Snooker championship is set to be played in front of a capacity crowd on the 3rd of may. The tournament is part of the governments pilot scheme to ensure fans can safely return to sporting venues. The crucible can hold 980 spectators, and the plan is for it to be a third full for the opening round, increasing as the tournament progresses. Face coverings will be required and fans will have to take a covid test before arriving and another five days afterwards. In snicker, we are all show Men And Women and without that crowd there to perform two, it is difficult, you imagine a west and singer walking on stage to nobody. It is very difficult. Of course the musical does not change and the support has not changed, no one has moved the pockets but we all like the 12 man analogy, the crowd are like the 12 men and they can bring that out a few. I hope i am in the next but whoever is in the mix, it will be worth waiting for. There will be one major absentee from the first round of golf� s masters tomorrow and thats tiger woods. The five time champion is still recovering from a car crash, which this evening, the Los Angeles County sheriff has said was caused by driving at a speed that was unsafe. They said he was travelling at up to 87 Miles Per Hour in february, when the speed limit was a5. I know theres a lot of experts who claim the drug connection, they say they should have drawn blood or done this or done that and without the signs of impairment, we dont get to the point where we can actually offer a Search Warrant and develop the proper cause to develop that and search that warrant, that is not preferential treatment, that would occur in any collision of this type based on those circumstances. Just time to tell you chelsea are still 0 0 at porto in the Champions League quarterfile for sleigh. Thats all the sport for now. Well have more for you on the bbc news channel later on. Austin thanks for the update. Some effects of the pandemic are obvious, others are largely unseen. After more than a year of lockdowns and social distancing official figures reveal a growing and disturbing loss of well being. 3. 7 Million People class themselves as lonely, thats over a million more than last year. The report also found that areas with large numbers of young people, unemployment and high density living tend to be most affected. Elaine dunkley reports from manchester. 0pened during the pandemic, the feel good club couldnt come at a more needy time. Somewhere over here, when we are all laid back out again, is where our big talk table is going to go. It will be a signal to other people that you are here open to chatting to new people and making new friends. Keira and her wife amy hope when their coffee house is fully reopened, it will feel like a home for those affected by loneliness and isolation. I think what the pandemic has taught us is that actually being open about those feelings and talking about them helps. The small moments where you meet friends and off load, i think that has become very apparent to people that those things that we kind of took for granted pre pandemic are actually so important. People in busy towns and cities are often the loneliest. According to todays report, by the office for national statistics, a greater concentration of young people and high unemployment rates are majorfactors. 16 to 2a year olds were four times more likely to say they had recently felt lonely compared to the over 75s. Lonely young people turn into lonely adults. And if we dont talk about these things it becomes something that has a massive stigma around it. 16 year old allon is a young carer and often feels isolated. Claire has also experienced loneliness. I feel like the minute you say this person is a young person, they are always on the phone, they are talking to their friends, they are always connected. Yes, i have my phone or maybe i text my friends. But doesnt mean im not lonely. Lockdown, isolation and social distancing has intensified the Public Health issue of loneliness. Jed usually djs in care homes but has been unable to because of the pandemic. Through the charity manchester cares, he has been able to connect with different age groups struggling with loneliness. Many people dont even have a computer, you know, the older people. So i have been lucky enough to have a laptop and join in with activities. The older people welcome listening to a younger persons point of view. And in the opposite way the younger people like listening to the older peoples tales, you know, of things gone by and in the past, what we used to do. For some people, lockdown has been the First Experience of loneliness. For others, it has been a long term problem. For those wanting to break the stigma, highlighting the issue offers hope. Elaine dunkley, bbc news, in manchester. Lets bring you up to date with some of the other news stories. Schools and colleges in england where students have reported incidences of Sexual Violence could be visited by inspectors from the regulator, 0fsted. The watchdog has announced it will visit a sample of schools and colleges where cases have been highlighted. Inspectors will assess how well schools respond and support their pupils. It comes after more than 11,000 reports of abuse were posted anonymoulsy by students on a website. Doctors treating patients with chronic pain, where the cause is unclear, have been advised not to prescribe painkillers. The National Institute for health and care excellence said that to avoid possible addiction, people should instead be offered a range of therapies including Exercise Programmes and anti depressants. 24 year old azam mangori has been sentenced to Life Imprisonment for the murder of lorraine cox who went missing after a night out with friends. Mangori killed her in his flat in exeter last september. He then disposed of her remains in bins and woodland. A man has won a High Court Case against a betting firm after it refused to pay a £1. 7 million jackpot he won in an online casino. Andrew green said he was devastated when betfred told him it would not pay out on his win in 2018 because of what it called a defect in the game. Our Home Affairs Correspondent tom symonds has the details. For andy green it was the night of the big wins. 0ne after another, his luck held out. By the end, this was his jackpot. More than £1. 7 million. So when you saw that figure on your phone, what was your reaction . I cried. Just gobsmacked. I took screenshots of it to keep as a memory. Not to keep as proof for three and half years in court because betfred said the game had gone wrong. It wasnt paying up. He took another gamble and took betfred to court. What was going through your mind, what were the emotions . Its devastating. Devastating. I felt like somebody had just put their hand down my throat and ripped my heart out. The judge decided betfreds terms and conditions were not transparent orfair. Andy will now receive around £2 million. I look at myself today and all the way through this as a small fish in a big pond. Fighting a shark. But today proves that little fish has taken a big bite out of that shark andy is celebrating. Betfred has apologised for the delay, three and a half years he experienced in receiving his money. Tom symonds, bbc news, the high court. An International Team of Scientists Say they have found strong evidence for the existence of a new force of nature. Theyve discovered that Sub Atomic Particles called muons dont behave in a way predicted by current theories of physics. The uk funders of the research say that science is on the precipice of a new era of physics. 0ur science correspondent, pallab ghosh, has more. The theories of modern physics have given scientists a new understanding of how the universe works. But the current ideas arent able to solve some of the biggest scientific puzzles, such as how the universe as we know it came into existence. Now, scientists at fermi lab, a Particle Accelerator just outside chicago, have got a result that might take us a big step forward in answering those questions. Theyve been accelerating particles inside this giant ring close to the speed of light, and they found that they might be behaving in a way that cant be explained by the current theory of physics at the subatomic level. We found that the interaction of a muon, which is a Heavy Electron with a Magnetic Field is not in agreement with our current best theory of physics, and clearly thats very exciting, because it potentially points to a future of new laws, new particles and new forces in physics which we havent seen up to date. You have heard of electrons, well, there are similar particles called muons which are much heavier and spin like tops. In the experiment, they were made to wobble using magnets. The current theory suggests they should wobble at a certain rate, instead, they wobbled faster. This might be caused by a Mystery Force that in turn is created by another yet to be discovered particle. Scientists believe that there are four fundamental forces of nature, one for gravity, another for electricity and two nuclear forces, which control the behaviour of atoms. Together, they explain the way the world works, but in recent years, astronomers began noticing things in space that cant be explained by the four forces, such as galaxies spinning faster than they should. And they cant explain why the stars and planets and everything on them, including us, exist at all. The new result suggests there might be a fifth force which could explain some of these mysteries. I think its quite mind boggling, and they have the potential to turn physics on its head. We have a number of mysteries that remain unsolved, and this could give us the key answers to solve these mysteries. Evidence for the fifth force has been growing, just two weeks ago, researchers at the large Hydron Colliderjust Outside Geneva had a similar result. The race is really on now to try and get one of these experiments to really get the proof that this really is something new. They will take more data and make more measurements and hopefully show evidence that these effects are real. These very early results arent definitive yet, but they are generating a lot of excitement about the prospect of a giant leap forward in our understanding of the universe. Pallab ghosh, bbc news. Some Breaking News for you. The sad news from the metropolitan police and the search for a 19 year old young man, richard 0korogheye. They have said that the body that had been found in Epping Forest is indeed that of the 19 year old who has been missing from west london and since the 22nd of march. So the metropolitan police just bringing and since the 22nd of march. So the metropolitan policejust bringing us up metropolitan policejust bringing us up to date with this developing story that they have been informed by their colleagues from essex police that the body of a man which had been found in a lake in Epping Forest is indeed after formal identification that of 19 year old richard 0korogheye. He went missing from Lead Brooke Grove back on the 22nd of march. We are expecting police to give us a statement, This Is The Life seen from new Scotland Yard where the metropolitan police, we are waiting for them to just bring us up to date. The next of kin have been informed, they are being supported by specialist officers but of course very sad news that the body that had been found in the wake in Epping Forest is indeed 19 year old richard 0korogheye. His death is being treated as unexplained and police do not believe at this stage that there was any Third Party Involvement following a Postmortem Forensic Which took place on the 7th of april. The cause of death is pending further investigations. Just that news that confirmation and we are awaiting the metropolitan police to make a statement about this developing story. Its take a break and bring you up to date with all the weather news. Hello, a little less cold for the next few days but dont drop your guard arctic air comes back into the weekend. Frosty nights again by then. Sunshine and wintry showers. Theres rain across Northern Ireland pushing into scotland overnight preceded by a little bit of snow into the hills, some rain reaching in towards parts of wales and western england. Elsewhere, though, where youre getting to see a few breaks in the clouds, still cold enough for A Touch Of Frost although not nearly as cold as it was last night. Into tomorrow, plenty of cloud around. Some patches of rain. Still some sunshine towards North East Scotland for a time before the Heavy Rain North West Scotland sinks across Scotland Southwards as the day goes on with a strengthening wind. It will get into Northern Ireland as we go on through thursday evening. Not much rain into east anglia south east of england, only very limited sunny spells, the air coming in from a less Cold Direction that will be turning breezier but with air from the west rather from the north, some temperatures showing up into double figures here before, again, it gets colder for the weekend. Hello, youre watching bbc news. Im kasia madera. The main headlines people under the age of 30 in the uk are to be offered an alternative to the astrazeneca Covid Vaccine, because of evidence linking it to extremely rare blood clots in a very small number of cases. The eu Drug Regulator also updated its guidance, concluding that unusual blood clots should be listed as a very rare side effect. The uk now has its third coronavirus vaccine. The first doses of the Moderna Vaccine have been given in wales and scotland, with a 24 year old carer the first to receive it. Police confirm the body found in a lake in Epping Forest, essex is that of missing 19 year old richard 0korogheye. The Foreign Office suspends uk aid funding for 0xfam again after fresh allegations of misconduct were levelled against staff working for the charity. A gambler who was denied a £1. 7 millionjackpot over an alleged Software Glitch wins his legal Battle Against Betfred to claim the playout, plus interest. Hello, welcome. Many of you have been sending in your questions about the Oxford Astrazeneca jab, after the uks regulator issued new guidance. Growing evidence that, in extremely rare cases, some people who have had the jab went on to develop blood clots means that people aged between 18 and 29 will now be offered an alternative to the Astrazeneca Jab. Over the next half hour, were going to be speaking to professor Robin Shattock, the head of immunity at Imperial College london, and also dr brian ferguson, immunologist at cambridge university, to answer your questions. But first, lets look at the numbers this affects. Up until the end of march, the mhra said there were 79 cases of blood clots with low platelets following the first dose of the Oxford Astrazeneca vaccine. 19 people have died. Thats out of 20 Million People who have had the jab. Thats one rare clot for every 250,000 vaccinations. Lets look a bit closer at the numbers. At the News Conference this afternoon, Professorjonathan Van Tam showed this slide to help explain the decision not to give astrazeneca to under 30s. The potential benefits of the vaccine are the blue dots on the left, which represent the number of people who avoid entering Intensive Care because theyve had the jab. The orange dots on the right represent the number of people who might suffer harm because of the vaccine. This slide is for a scenario where coronavirus isnt circulating heavily among the population a scenario the uk is on course to reach. And you can see that for the 20 to 29 age group, the Benefit Figure is 0. 8 and the harm figure is 1. 1. In other words, for under 30s, for whom risks from coronavirus are low, the risk of harm from the vaccine is higher than from the virus itself, but for older people, its overwhelmingly better for them to have the vaccine. Professor van tam then went on to show the Risk Benefit Analysis for a medium amount of Coronavirus Cirulating in the uk, and a high level of exposure. This is now a medium risk scenario, and it is set at 60 cases per 100,000. That is marginally higher than the uk average at the moment, but it is lower than some of the remaining hotspots in the uk. And you can see that when the disease is around us more, when theres more exposure, then the benefits, the potential benefits, start to stack up, but the potential serious harms remain static, of course. And this is still over a 16 week period and you can see that the data becomes more overwhelming, in terms of vaccine benefit. Finally, lets move to a high exposure risk. And this one next slide, please is set, typically, at where well get to, in terms of a Pandemic Wave. This is set at the height of the second Pandemic Wave that we went through in the last few months and i think is reflective of the kind of scenario we want to avoid in the forthcoming autumn and winter if we possibly can. But here, when theres a lot of covid 19 circulating in the population, you can see that even in the 20 to 29 group, the potential benefits, in terms of Intensive Care admissions averted, is very much higher than the serious harms due to vaccine. And thats why the regulators have concluded as they have about risk benefit for the astrazeneca vaccine. Professorjonathan professor Jonathan Van Tam Professorjonathan Van Tam at that Press Conference it little bit earlier on today. Youve been sending in your questions on the vaccines. And to answer them, were joined by professor Robin Shattock, head of immunity at Imperial College london, and dr brian ferguson, an immunologist at cambridge university. Gentleman, think you very much for joining us. We will crack on street away, because we have an awful lot of interest in this and a lot of questions, so professor robin, im going to come to you first. Claire is asking if you are under 30 and have had the first dose of astrazeneca, what should you do . Should you have the second dose . Yes, she should definitely go ahead and have the second dose, that is what is recommended at the moment, and so far we have no recorded cases of this type of blood clot with the second dose of the astrazeneca vaccine. It does not mean it completely removes the risk, but it looks so far as of the risk may be lower, if you have had a first dose and not had an adverse event. And lower, if you have had a first dose and not had an adverse event. And in keein in and not had an adverse event. And in keeping in line and not had an adverse event. And in keeping in line with and not had an adverse event. And in keeping in line with this and not had an adverse event. And in keeping in line with this idea and not had an adverse event. And in keeping in line with this idea of keeping in line with this idea of the second dose, dr brian ferguson, kim is asking, will people under 30 who have had Theirfirst Kim is asking, will people under 30 who have had their first astrazeneca dose be offered an alternative dose for their second, dose be offered an alternative dose fortheirsecond, or dose be offered an alternative dose for their second, or is it not possible . If for their second, or is it not possible . For their second, or is it not possible . For their second, or is it not ossible . I. , possible . If you had the first dose of after zeneca, possible . If you had the first dose of after zeneca, you possible . If you had the first dose of after zeneca, you will possible . If you had the first dose of after zeneca, you will be possible . If you had the first dose | of after zeneca, you will be offered the second of after zeneca, you will be offered the second dose astrazeneca as well, as is currently the guidance, not mixing as is currently the guidance, not mixing between shots, so, no, you and i mixing between shots, so, no, you and i get mixing between shots, so, no, you and i get the mixing between shots, so, no, you and i get the choice of swapping out the az and i get the choice of swapping out the a2 for and i get the choice of swapping out the a2 for a and i get the choice of swapping out the a2 for a new vaccine. The and i get the choice of swapping out the az for a new vaccine. The az for a new vaccine. The same one, the az for a new vaccine. The same one. Thank the az for a new vaccine. The same one. Thank vou the az for a new vaccine. The same one, thank you. Professor the az for a new vaccine. The same one, thank you. Professor robin, l one, thank you. Professor robin, becky is under 30, becky has had the usher had the Robin Shattock vaccine and wants to know what she has to look out for in terms of blood clots now. ,. ,. ,. ,. ,. , now. Things to be aware of, a persistent now. Things to be aware of, a persistent headache now. Things to be aware of, a persistent headache lasting. Now. Things to be aware of, a persistent headache lasting more than four days, blurred vision, confusion, shortness of breath, chest pains or swelling of your legs or a long term, persistent domino pain, orsome kind or a long term, persistent domino pain, or some kind of severe bruising around the Injection Site becky has had the Oxford Astrazeneca vaccine. Those are the things that are worth taking note of them getting a medical opinion as soon as possible if you have any of those symptoms. Thank ou. And have any of those symptoms. Thank you. And following have any of those symptoms. Thank you. And following on have any of those symptoms. Thank you. And following on from have any of those symptoms. Thank you. And following on from that,. Have any of those symptoms. Thank you. And following on from that, dr| you. And following on from that, dr brian, suzanne asks a question that actually a lot of people are asking in the newsroom here. How quickly after having the oxford vaccine did these rare blood clots occur . The vast majority these rare blood clots occur . The vast majority occurred within the first 14 vast majority occurred within the first 14 days, post vaccination, so that is first 14 days, post vaccination, so that is the first 14 days, post vaccination, so that is the kind of timeframe to be looking that is the kind of timeframe to be looking out for for some obviously anytime looking out for for some obviously anytime post vaccination, if youre suffering anytime post vaccination, if youre suffering from this kind of symptoms that Professor Shattockjust outlined, go ahead and seek medical advice outlined, go ahead and seek medical advice as outlined, go ahead and seek medical advice as soon as possible. Gk, outlined, go ahead and seek medical advice as soon as possible. Advice as soon as possible. Ok, so thats really advice as soon as possible. Ok, so thats really important, advice as soon as possible. Ok, so thats really important, within advice as soon as possible. Ok, so thats really important, within the | thats really important, within the first 14 days. Robin, frank is asking, has anyone who has had the first Astrazeneca Jab without this got in the rare side effect with the second jab . 50 got in the rare side effect with the second jab . Second ab . So far, no reported blood second jab . So far, no reported blood clots second jab . So far, no reported blood clots after second jab . So far, no reported blood clots after the second jab . So far, no reported blood clots after the second second jab . So far, no reported i blood clots after the second dose, but we after member the number of people having two doses is much lower than the number of people having a single dose, so it is still an open question do we know that people have a stronger response to the first dose of the vaccine, so it is probable but not certain that, if you have not had a bad response to the first dose, you are not likely to get a bad response to the second dose. , to get a bad response to the second dose. ,. , to get a bad response to the second dose. , ~ , � to get a bad response to the second dose. , i. ~ �. , dose. 0k, thank you. And, brian, karen is asking, dose. 0k, thank you. And, brian, karen is asking, is dose. 0k, thank you. And, brian, karen is asking, is the dose. 0k, thank you. And, brian, karen is asking, is the risk dose. 0k, thank you. And, brian, karen is asking, is the risk of karen is asking, is the risk of clutching higher in young women currently taking the Birth Control pill . Currently taking the Birth Control ill . ,. ,. , pill . There is no evidence in an increased pill . There is no evidence in an increased risk pill . There is no evidence in an increased risk of pill . There is no evidence in an increased risk of this pill . There is no evidence in an increased risk of this particular| increased risk of this particular type increased risk of this particular type of increased risk of this particular type of clot being higher postvaccination with the pill, or indeed postvaccination with the pill, or indeed any other medicine, at the moment, indeed any other medicine, at the moment, so while people are on the pill to moment, so while people are on the pill to have moment, so while people are on the pill to have a general increased risk of pill to have a general increased risk of clotting, it is not, there is no risk of clotting, it is not, there is no link risk of clotting, it is not, there is no link between the vaccine type and clot is no link between the vaccine type and clot that has been caused with the pill, and clot that has been caused with the pill, so and clot that has been caused with the pill, so that is currently, there the pill, so that is currently, there is the pill, so that is currently, there is no the pill, so that is currently, there is no link there at all. Gk, there is no link there at all. Ok, so thats birth there is no link there at all. Ok, so thats Birth Control. There is no link there at all. Ok so thats Birth Control. What about hrt, joanne was asking, does that increase your chances of blood clots . �. , increase your chances of blood clots . ~. ,. ,. , clots . Again, currently the answer no, it clots . Again, currently the answer no. It does clots . Again, currently the answer no. It does not clots . Again, currently the answer no, it does not increase clots . Again, currently the answer no, it does not increase the clots . Again, currently the answer no, it does not increase the risk i clots . Again, currently the answer no, it does not increase the risk of blood clots, and i think it is to put this into useful to put this into context up having the vaccine with the pill or Hormone Replacement Therapy is not more likely our we are quite happy to have those two types of approaches. Without thinking too much about the risk of underuse. , � , ,. , underuse. Ok, thats pretty clear, thank you underuse. Ok, thats pretty clear, thank you. Brian, underuse. Ok, thats pretty clear, thank you. Brian, if underuse. Ok, thats pretty clear, thank you. Brian, if you underuse. Ok, thats pretty clear, thank you. Brian, if you have thank you. Brian, if you have conditions that already make you susceptible to blood clots, should you reject the astrazeneca vaccine . The current advice is that if you are predisposed to specific types of blood are predisposed to specific types of Blood Disorders that lead to clotting, you should talk to your gp, your clotting, you should talk to your gp, your doctor, before having to ab. Gp, your doctor, before having to jab that gp, your doctor, before having to jab. That would be a discussion that would jab. That would be a discussion that would be jab. That would be a discussion that would be most sensible to have currently would be most sensible to have currentl. �. , g. , currently. And, robin, june asking, is it ust currently. And, robin, june asking, is it just the currently. And, robin, june asking, is it just the ashes currently. And, robin, june asking, is it just the ashes zeneca currently. And, robin, june asking, is it just the Ashes Zeneca Vaccine L is itjust The Ashes Zeneca Vaccine Or has the Pfizer Vaccine also had these blood clots reported astrazeneca vaccine . These blood clots reported astrazeneca vaccine . These blood clots reported astrazeneca vaccine . Theres been a coule of astrazeneca vaccine . Theres been a couple of reports astrazeneca vaccine . Theres been a couple of reports of astrazeneca vaccine . Theres been a couple of reports of blood astrazeneca vaccine . Theres been a couple of reports of blood clots couple of reports of blood clots associated with the Pfizer Vaccine. It really is below the Background Level you would expect, so so far, there does not seem to be the same association, although we still need to be clear that this association with the astrazeneca vaccine looks probable but it is still not proved beyond all doubt. The other thing, with the Pfizer Vaccine, its been used very widely in the us, and we are not seeing an increase Reporting Rate of blood clots with the very wide use of the Pfizer Vaccine in the us. � , wide use of the Pfizer Vaccine in the us. �. , ,. , wide use of the Pfizer Vaccine in the us. �. ,. ,. , the us. And, robin, ust on that note, i wonder the us. And, robin, ust on that note, i wonder if the us. And, robin, ust on that note, iwonder if i the us. And, robin, just on that note, i wonder if i could the us. And, robin, just on that note, i wonder if i could just the us. And, robin, just on that l note, i wonder if i could just throw regarding myjournal. Do we have the figures yet, with this latest approved here . Moderna. The approved here . Moderna. The moderna approved here . Moderna. Tue Moderna Vaccine approved here . Moderna. Tte Moderna Vaccine does approved here . Moderna. Tte Moderna Vaccine does not approved here . Moderna. Tte Moderna Vaccine does not seem approved here . Moderna. Tte Moderna Vaccine does not seem to be linked to a increase in blood clots at this point, and that is also used highly in the us. It is particular with the astrazeneca vaccine. That is not to say that picture might change with other vaccine starting to use more widely over time. We are only being able to see this literally looking at hundreds of millions of people globally getting these particular vaccine candidates. Sure, 0k, these particular vaccine candidates. Sure, ok, thats pretty clear, and, brian, and asking, what a good question, are under 30s allowed to have the after zeneca vaccine anyway if they want to have a . Tt. Have the after zeneca vaccine anyway if they want to have a . If they want to have a . If, at the moment. If they want to have a . If, at the moment. What if they want to have a . If, at the moment, what will if they want to have a . If, at the moment, what will happen, if they want to have a . If, at the moment, what will happen, if i if they want to have a . If, at the l moment, what will happen, if they are offered the vaccine, they will be allowed to choose a different vaccine, be allowed to choose a different vaccine, pfizer or moderna, in place ofthe vaccine, pfizer or moderna, in place of the astrazeneca vaccine if there offered of the astrazeneca vaccine if there offered it of the astrazeneca vaccine if there offered it. If they are not offered it, offered it. If they are not offered it. If offered it. If they are not offered it. If for offered it. If they are not offered it, if for example in their region the pfizer it, if for example in their region the Pfizer Vaccine is not being given the Pfizer Vaccine is not being given to the Pfizer Vaccine is not being given to the particular population, they will given to the particular population, they will not be able to choose to have they will not be able to choose to have the they will not be able to choose to have the s they will not be able to choose to have the s zeneca vaccine in place of the have the s zeneca vaccine in place of the one have the s zeneca vaccine in place of the one they are being offered. But he of the one they are being offered. But he will of the one they are being offered. But he will be able to do the other way around, so they will be if if they are offered the astrazeneca one, they. They can take astrazeneca one, they. They can take the astrazeneca one, they. They can take the pfizer or Moderna Vaccine. I take the pfizer or Moderna Vaccine. I wonder. Take the pfizer or Moderna Vaccine. I wonder, robin, take the pfizer or Moderna Vaccine. Iwonder, robin, in take the pfizer or Moderna Vaccine. I wonder, robin, in terms of your reaction to this slight change in the directive of how to use the astrazeneca and who should receive it, what do you make of it come what is your initial reaction to this . T is your initial reaction to this . I think my initial reaction is it shows the government is being very transparent about the whole process, it is a precautionary step, is not necessarily required. Other countries are not doing it. Obviously we do have supplies of other vaccines and so they are playing it very safe, and they are laying out the risks and benefits, and i think that transparency is really critical for people to understand the situation and make their own choices. Understand the situation and make their own choices. And, brian, when we are talking their own choices. And, brian, when we are talking about their own choices. And, brian, when we are talking about the their own choices. And, brian, when we are talking about the numbers, | we are talking about the numbers, just put that into perspective, the realistic chance of having this very rare blood clot. The realistic chance of having this very rare blood clot. Rare blood clot. The realistic chance is rare blood clot. The realistic chance is tiny. Rare blood clot. The realistic chance is tiny. You rare blood clot. The realistic chance is tiny. You laid rare blood clot. The realistic chance is tiny. You laid it. Rare blood clot. The realistic| chance is tiny. You laid it out right chance is tiny. You laid it out right at chance is tiny. You laid it out right at the beginning, where it is one in right at the beginning, where it is one in 250,000 people are seeing any kind of one in 250,000 people are seeing any kind of clots one in 250,000 people are seeing any kind of clots after taking the vaccine kind of clots after taking the vaccine and one in a Million People have vaccine and one in a Million People have unfortunately died after taking this vaccine with this type of clot. Again, this vaccine with this type of clot. Again, that this vaccine with this type of clot. Again, that is a correlate of link at the again, that is a correlate of link at the moment, there is no causality there at the moment, there is no causality there it at the moment, there is no causality there it is at the moment, there is no causality there. It is not necessarily the vaccine there. It is not necessarily the vaccine causing those debts, although this is being absolutely studied although this is being absolutely studied very hard at the moment, to see if studied very hard at the moment, to see if there studied very hard at the moment, to see if there is a causal link. To put into see if there is a causal link. To put into perspective, a ticket to the same put into perspective, a ticket to the same kind of risk as being murdered the same kind of risk as being murdered in the next month or Something Like that. There was somebody putting the same kind of Risk Analysis therefore it is an extremely low risk of having an adverse extremely low risk of having an adverse reaction, and it is extremely much lower risk than there is of ill extremely much lower risk than there is of ill health from covid, including long covid and including other including long covid and including other kinds of problems from getting the disease, so that is why the risk benefit the disease, so that is why the Risk Benefit Analysis is so important and i benefit analysis is so important and itotally benefit analysis is so important and i totally agree with what Professor Shattock i totally agree with what Professor Shattock says, which is that the transparency that was present in the press transparency that was present in the Press Conference today, and all of the data Press Conference today, and all of the data that has been presented and is now the data that has been presented and is now publicly fallible to see, how this risk is now publicly fallible to see, how this risk is is now publicly fallible to see, how this risk is being analysed, and how the advice this risk is being analysed, and how the advice is this risk is being analysed, and how the advice is being given to individuals to allow them to make their choices is extremely positive and very their choices is extremely positive and very helpful indeed. We their choices is extremely positive and very helpful indeed. Their choices is extremely positive and very helpful indeed. We will put that like that, and very helpful indeed. We will put that like that, that and very helpful indeed. We will put that like that, that certainly and very helpful indeed. We will put that like that, that certainly puts. That like that, that certainly puts it into perspective. Thank you, just one final one to you, robin, if i may. I know you have been working with looking at variance and how that works, and we know brazil has never recorded a very, 4000 covi related deaths, they are looking at a more contagious variance. When it comes to the vaccines, how can they change . And kind of fight against the different variants that are coming through . Tt is the different variants that are coming through . It is certainly ossible coming through . It is certainly possible to coming through . It is certainly possible to change coming through . It is certainly possible to change these coming through . It is certainly l possible to change these vaccine coming through . It is certainly possible to change these vaccine so they can accommodate these kind of variations, and it may be that that is something that might be needed by the time we approach the winter. What is really critical right now is to keep the number of cases in the uk as low as possible until we have got maximal vaccine coverage, and that means that everybody getting two doses, because we anticipate with that, even if the vaccine were to lose some activity against getting the infection, they should still prevent people ending up in hospital or potentially dying from covid. So its kind of a race, in the uk, to get those vaccines out and keep the case is low, and that is like listening to be slightly cautious about unlocking too quickly and paying real attention to the data. �. ,. ,. ,. ,. , data. And on that note, i want to thank you data. And on that note, i want to thank you both data. And on that note, i want to thank you both extremely data. And on that note, i want to thank you both extremely for data. And on that note, i want to | thank you both extremely for your expertise and your time, professor Robin Shattock, head of immunity at Imperial College london, and dr brian ferguson, immunologist at cameron university. Thank you very much for giving us your responses to the rather excellent questions from our viewers. The Hashtag Hashtag your questions answered. Bbcyourquestions. Thank you. People diagnosed with covid 19 appear to be at greater risk of developing psychological and neurological conditions, including depression, psychosis and stroke. A study by Oxford University examined the Health Records of more than half a million patients in the United States and found almost all the main Brain Illnesses were more common in people whod caught the virus. Heres our Health Reporter rachel schraer. Coronavirus breaks into our cells and multiplies wherever in the body it finds itself. Thats why it causes such a wide range of symptoms from the lungs, to the gut, to the brain. The team at the university of oxford looked over half a million Patient Records in the us to see if conditions affecting the brain were more common in those whod had covid. They looked at 14 conditions including anxiety, depression and psychosis, stroke, Brain Haemorrhage and dementia. All of these conditions were seen more often in people whod had a Covid Infection in the previous six months. But these conditions all have very different causes. It could be that in some people, the virus actually gets into the brain and causes some damage. It could be the way your body is reacting to the virus, produces a sort of immune or inflammatory response that, again, contributes to the problems. And for other people, it may simply be a psychological effect, if you like, of the stress that having covid and thinking what might happen to you next is the important factor. The study couldnt prove the virus itself was definitely causing the changes, but patients recovering from covid were more likely than similar people whod had flu or another infection to develop a psychological or neurological condition. And the sicker coronavirus patients had been, the more likely they were to develop these complications. Rachel schraer, bbc news. King abdullah ofjordan has said that a crisis sparked by an alleged plot involving the former crown prince hamzah has been brought under control. In an address to the nation, the king said sedition had been nipped in the bud. He described the affair as painful. Over the weekend, prince hamzah was accused of conspiring to destabilise the country. He released a video in which he denied this, but he was also bitterly critical of the wayjordan was being governed. Later, after mediation efforts, the prince pledged his allegiance to the king, his half brother. Human Rights Group Amnesty International says that kremlin critic Alexei Navalny has been incarcerated in conditions that amount to torture and may slowly be killing him. Mr navalny tested negative for the coronavirus on wednesday, but his health has deteriorated and he has been on a Hunger Strike since last week, in protest at what he said was the refusal of Prison Authorities to treat him properly for acute back and leg pain. People living in cities have been urged to think twice before buying suvs which are meant for the countryside. The Motoring Organisation the rac says drivers should choose vehicles which are less polluting, when they dont Need To Plough across rivers or fields on their way to the shops. Research suggests most Sports Utility Vehicles are now bought by people who live in urban areas, particularly london. Roger harrabin reports. 4x4 Wheel Drive cars are officially called suvs, Sports Utility Vehicles. To people who hate their bulk on city streets, there is a less respectful title chelsea tractors. New Research Shows that most of them are indeed bought in kensington and chelsea, Hammersmith And Fulham and westminster, london boroughs where wealthy residents can afford the prices. It is a far cry from the origins of the chelsea tractor, the Humble Workhorse land rover, loved by farmers, Country Dwellers and the military. Their appeal has spread into the towns. Two thirds of these cars are being sold to People Living in cities where there are no opportunities to drive off road. So actually, our call is not so much to consumers to think twice. What we are asking for is for these vehicles to stop being advertised in the uk. It is part of a trend towards bigger cars that has kept Carbon Emissions from transport unacceptably high. The classic mini, for instance, was 3. 05 metres long. The new version mini is 3. 82 metres long. Compare the huge mercedes gls. It is 5. 21 metres. And beasts like this are too big for a conventional parking space. If suv drivers were a country, they would be seventh in the world for Carbon Emissions. People choose different cars for different reasons. It might be style. It might be safety. It might be seating position. Indeed, it might be size. If people have got a big family, they want a bigger car. If they want to tow things, they might need a bigger car. But not all suvs are big and dirty. Some of the cleanest cars are now coming in the style of suvs. That means electric suvs, although they are only part of the solution. They waste energy, dragging tonnes of steel with heavy batteries through city streets, like this electric hummer, based on an American Army truck. It is a beast. Banning advertising for suvs would help, campaigners say, just as adverts for smoking are banned. It wont work, motoring groups warn. They say people buy suvs for all of the space inside and because they are good to drive. Roger harrabin, bbc news. Your thoughts are always welcome. I will be back a little bit laterfor the papers, but now lets bring you up to date with the weather. Here is nick miller. Hello. Its hard to think of two weeks of Spring Weather that could be more opposite. Last week, we had the warmth, temperatures into the 20s. This week, its the cold, the frost, the snow, not even as much sunshine around the wintry showers today. We are turning things for the next couple of days a little less cold, the arrows not pointing down from the north, but coming in from the atlantic instead. But itll be very short lived, because the arctic air comes right back at us into the weekend. Now with this less cold air coming in from the atlantic, were starting to bring in a bit more cloud today, and we may see a bit of rain out of that, as well. Northern ireland through the evening, overnight pushing them toward scotland, the western side, some rain into wales and western parts of england. East of all of that, with any clear spells, temperatures will still fall low enough for A Touch Of Frost, but not as cold as it was last night. So tomorrow, plenty of cloud around again out of that cloud, some rain, particularly Northwest Scotland with a strengthening wind here. Elsewhere, it willjust be very patchy in nature some sunny spells in Northeast Scotland until the afternoon, and for east anglia and the southeast, although a fair amount of cloud, a few brighter breaks, but not much of any rain as we get into the evening. The winds are picking up with the rain in scotland, its a breezier day elsewhere but remember, this is that less cold air coming in from the west, which is why there are actually some double figure temperatures showing for thursday. Now as we go on through the evening, well take this area of rain, clear it away from scotland, push it across Northern Ireland and into Northern England thats our cold front, behind which the arctic air is coming back. On friday, its very slowly moving further south through england and wales where it clears from Northern England, Northern Ireland, and scotland back into the cold arctic air. Therell be some sunshine around again, also a few wintry showers, and these snow showers are packing in once again to northern scotland. Now looking at the picture going into the weekend, the cold front clears away only to be replaced by more Weather Fronts heading up from the south this time, toward southern england. Some uncertainty about how far north any rain will get from those on saturday before clearing on into sunday, so keep across the forecast. But for many areas over the weekend, its cold, quite sunny, chance of a few wintry showers and coming back will be those frosty nights again. This is bbc news side effect or red flag . The eus medicines regulator says blood clots do occur with the astrazeneca vaccine. The risk is extremely low, but those under 30 in the uk will be offered a differentjab if they want it. Uk government scientists assure the public that the vaccine is safe and is still the countrys best hope for ending the pandemic. Changes in preference for vaccines are business as usual and this is a course correction. Going from bad to worse in brazil. The country has recorded 4000 deaths in a single day, its highest ever total. Well speak live to a Critical Care doctor. Also on the programme. Former President Trump weighs in on the matt gaetz scandal. He denies the congressman asked him for a pardon,