Delays in treatment, for thousands of Cancer Patients because of the pandemic, we hear one womans story. Everything was good to go, and then coronavirus. So when i went back, in april, the tumour had started growing and it was too late to do the procedure. find growing and it was too late to do the procedure. Growing and it was too late to do the procedure. And also today, how ureen is the procedure. And also today, how green is your the procedure. And also today, how green is your football the procedure. And also today, how green is your Football Club . The procedure. And also today, how green is your Football Club . Fans i green is yourFootball Club . Fans are encouraged to persuade their team to be more environmental. And coming up on bbc news, zak crawley� s been ruled out of the first two tests against india after spraining his wrist in a freak accident. The opener slipped on a marble floor. Good afternoon and welcome to the news at one. Scientists are investigating whether giving people different covid vaccines for their first and second doses would work as well as using the same kind ofjab twice. It is thought it could give more flexibility should there be disruption to supplies, and may even offer Greater Protection against the virus. The results will not be available until the summer, so there is no change to the Vaccine Programme yet stop this fire station in hampshire is the latest venue to become part of the latest venue to become part of the vaccine roll out, one of thousands of sites operating across the uk. More than ten Million People have had theirfirst the uk. More than ten Million People have had their firstjabs, the uk. More than ten Million People have had theirfirstjabs, but the uk. More than ten Million People have had their firstjabs, but a the uk. More than ten Million People have had theirfirstjabs, but a new study aims to find out if mixing doses of the Oxford Astrazeneca and Pfizer Biontech vaccines could offer the body even more chances to develop defences against the virus. What we are doing is seeing how well peoples Immune Systems respond if you give the first dose of one vaccine on the second dose of another. The reason to do that is to build flexibility into the uk Immunisation Schedule for vaccines. And even globally, it makes it much easier to administer the vaccines if we dont have to worry too much about always giving the second dose the same as the first dose. The trial will mix the same as the first dose. The trial will mix doses the same as the first dose. The trial will mix doses from the two vaccine is currently being used. But others could be added as they are approved. The study will involve 820 volunteers, none of whom have yet had the vaccine. All will be aged 50 or older, part of the group to be vaccinated in the next priority wave. The trial will run initially at eight sites across england. Tackling outbreaks of ebola is one reason they think it might work. Mixing vaccines was used successfully against this virus. A second boosterjab that uses another way of prompting an immune response can be more effective than two jabs from the same vaccine, and it is already in use with the many inoculations we are aware of. It is something inoculations we are aware of. It is something that inoculations we are aware of. It is something that is inoculations we are aware of. It 3 something that is done historically with vaccines or hepatitis, childrens vaccines, polio, measles, mumps and rubella. It will hopefully maintain the uk at the Forefront In Research Into Covid vaccines. We are proud of our record on the Vaccine Task Force on the deployment programme. But this is another part of the armoury. Programme. But this is another part of the amount of the armoury. Given the erratic nature of vaccine of the armoury. Given the erratic nature of vaccine supply, of the armoury. Given the erratic. Nature of vaccine supply, described by ministers as lumpy, a degree of flexibility in the Vaccination Programme could be a real help in the months to come. But perhaps the biggest benefit will be for those developing countries that have yet to get Vaccination Programmes up and running. Being able to mix and match supplies could make all the difference. The first results of this trial should be known by the early summer. Dominic hughes, bbc news. Lets talk more about this with fergus walsh. Is this trial really important . I fergus walsh. Is this trial really important . Important . I think it is. It is important important . I think it is. It is important and important . I think it is. It is important and also important . I think it is. It is important and also really i important and also really fascinating. Because this could be of practical help, both in the uk and elsewhere, where you could see potentially disruption in supplies of vaccine, and people coming along now will have the same type of vaccine they had when they had their booster, as their first dose. It later in the year, if we get disruption in supply, it would be really useful if you could swap around the vaccines. But really interesting for science as well. Because the pfizer and astrazeneca vaccines both target the spike protein, to get the Immune System to target that. But they do it in very different ways. They are differently designed vaccines. And really, its interesting to see whether mixing those vaccines may actually give a better overall immune response. And its not only going to be done in england, where this trial is due to start soon, astrazeneca is also talking to the scientists in russia who developed the sputnik vaccine, which released results, very impressive results, earlier this week. And they are going to do a trial there, week. And they are going to do a trialthere, mixing week. And they are going to do a trial there, mixing the astrazeneca vaccine and the sputnik vaccine, which both use very Similar Technology. Which both use very Similar Technology which both use very similar technolo . ,. ~ ,. , technology. Fergus, thank you very much. Technology. Fergus, thank you very much fergus technology. Fergus, thank you very much. Fergus walsh. The the owners of the Biggest Hotel chain say they have not heard from ministers about housing people there. The Prime Minister said last month that people coming from this country from 19 hotspots would have to quarantine in hotels, but no start date has been set. More than a week after it was announced, there are still no published plans on Quarantine Hotels and some hoteliers are getting frustrated. I think in my company, if we went and announced something nationally and we hadnt thought about how we were going to deliver that, and we hadnt engaged with the people who would actually have to deliver that, then im not sure i would even be in a job. Yesterday, the Prime Minister had said plans would be announced today. Number 10 said the Prime Minister had been misinformed. The announcement was always going to be made when the operation of the Hotel Quarantine was ready and it was with, i think the Prime Minister was saying within days, but. No, he said it would be today. Well, my understanding is that it was always going to be within the next few days. The governments policy only applies to arrivals from 33 high risk countries. Labour wants that applied to every country and are calling for a wider plan, fast. We are in a race iiow. Virus against vaccination. Lets secure our borders while we carry out the vaccination process. The uk could use elements of other Quarantine Hotel systems in other countries, like australia and new zealand. But there are other options to consider. Airports, airlines and hotels still have a lot of questions about how this is going to work. They range from the practical side, like whether guests can go out for managed exercise, down to safety and security questions, like whether passengers from high and low risk countries should be travelling together on the same flight or kept together at terminals. If you look at the australian model, there is Perimeter Fencing. Do we need to put up Perimeter Fencing . What sort of Air Ventilation is required . Who would supply security . Is it us . Weve got that available, but is that us or is it a Third Party Contractor . What if somebody breaches those rules, someone leaves the room, are we to fine them . Can they have outside phone calls . Just so many questions that really need to be answered. Creating managed quarantine is complicated and none of those involved want the system to be poorly thought through. But with the policy already announced and likely to dissuade travellers from booking far ahead, the industry says it needs answers for how this is going to work. Caroline davies, bbc news. One of the scientists that sits on the governments Advisory Group sage says he expects theyll be a phased opening up as the Vaccinations Levels increase with life more or less back to normal for the summer. Lets take a look at the key dates over the next few weeks. By 15th february, the government aims to have vaccinated everyone in the first four priority groups thats care home residents, front line health staff, everybody over the age of 70 and people who are clinically extremely vulnerable. On 22nd of february, the Prime Minister will set out a roadmap for how the government intends to ease restrictions in england. Schools would be the first to open to all pupils the government say that will happen on 8th of march at the earliest, in england. Schools may open earlier in wales scotland with a possible phased reopening from the 22nd february. Lets speak to our Political Correspondent nick eardley whos in westminster. Data coming out all the time. We talk about the vaccines. How much is all of this Putting Pressure on the Prime Minister over this issue of Easing Lockdown . Prime minister over this issue of Easing Lockdown . Well, we have erha s Easing Lockdown . Well, we have perhaps heard Easing Lockdown . Well, we have perhaps heard less Easing Lockdown . Well, we have perhaps heard less from Easing Lockdown . Well, we have perhaps heard less from some i Easing Lockdown . Well, we have| perhaps heard less from some of those in borisjohnsons party who want him to move more swiftly over the last few weeks, just because the data was so bad. But as the number of cases comes down, as the vaccine roll out continues to go pretty well, there are those influential backbenchers in borisjohnsons party who are increasingly knocking on his door and saying, we need to think about trying to get part of society open again. They are looking, for example, to the announcement in scotland, seeing the possibility of schools opening there on the 22nd of february, as a way that england could look to accelerate things a bit, potentially with a similar sort of aspiration. Ive got to say, i dont think number 10 is ive got to say, i dont Think Numberio is in ive got to say, i dont think number 10 is in that place at the moment. I think they are being very cautious. We heard the Prime Minister being very cautious in the downing street briefing last night. And i think in part that is due to the fact they dont want to open things up and closed them again. Some have been really stung by what happened over the christmas period, and the perception they were doing u turns on what could and couldnt open. Its also worth bearing in mind there are still those fears about variants coming into the country from other parts of the world. That is why the Quarantine Process is being strengthened in the next few weeks. It feels like we have been talking about it for ages. We are told that it will be next week when we finally get details of how that looks, and there have been some operational challenges to getting that done. Some operational challenges to getting that done. Nick, thank you for now. Getting that done. Nick, thank you for now the getting that done. Nick, thank you for now. The success getting that done. Nick, thank you for now. The success of getting that done. Nick, thank you for now. The success of the for now. The success of the Vaccination Programme will help the economy rebound strongly, says the man coming in. It has predicted growth in the spring as people become more confident about spending. Andy verityjoins me. Explain more about what the bank has been saying. In explain more about what the bank has been sa inc. , explain more about what the bank has been saying been saying. In some ways, jayne, the picture been saying. In some ways, jayne, the picture is been saying. In some ways, jayne, the picture is that been saying. In some ways, jayne, the picture is that it been saying. In some ways, jayne, the picture is that it didnt been saying. In some ways, jayne, the picture is that it didnt work the picture is that it didnt work out quite as bad last year as the bank earlier in the year thought it would. So, if you look at what happened to gross domestic product, thatis happened to gross domestic product, that is a measure of the size of the economy, everything we produce, every haircut, every bus ride, every car that is made, that shrank by 8 in 2020. But it could have been worse. At one point, the bank was saying it could be more like i2 . In the Fourth Quarter of the year there was actually slight growth, in spite of the tiered restrictions that were introduced. However, the banker saying that in the First Quarter of this year they are expecting the economy to shrink by 4 . If you add those together, the 4 shrinkage we are about to get on the 8 we have had, that means a 12 drop from peak to trough. That is nearly twice as bad as the financial crisis. So it is a really steep drop. On other hand, with the Bank Of England is saying is that when the Vaccination Programme starts taking effect over the coming year, the economy should get a big boost from that. So even though unemployment will rise, and quite seriously, up to close to 8 , about 2. 5 Million People, it should come down again as the economy continues to grow. It is projecting that the economy gets back to its pre covid level in the First Quarter of next year. After that, it says things are going to slow down a little bit. So dont expect Interest Rates to rise to combat inflation anytime soon. Rates to rise to combat inflation anytime soon rates to rise to combat inflation anytime soon. The pandemic has resulted in thousands of people having their scans or treatment for cancer delayed. Charities warn that in some cases the disease will have progressed while people were waiting to be seen and that emotional support is vital for those patients. Jayne mccubbin has been speaking to one woman whos been helped by a charity. On february the 6th, 2020, minna and kavi were married. A month later she was due to have potentially life saving surgery for pancreatic cancer. But this was the news on february the 6th. A third person has tested positive for coronavirus here in the uk. The virus had started to spread across the country and the impact on Cancer Services was devastating. Everything was good to go, and then coronavirus. Minnas surgery was cancelled. So then when i went back in april, the tumour had started growing and it was too late to do the procedure any more. Minna speaks to me from her bed at home, where her cancer journey is near its end. People suffer in silence. They dont know how much help there is. And what kind of help there is. In lockdown, facing a terminal diagnosis, she says her impossible situation was made bearable by one woman. A macmillan volunteer called julie, who she has never met, but who was on the end of a phone when she needed her most. We found a special connection. And it was like, you know when they say sometimes it was meant to be . Basically, because my mum had passed in 2017 with cancer, i wanted to give something back. People keep saying to you, be strong, you will fight it. You will go through it. To a certain point it is fantastic. But at some point its, like, ive had enough. Ive heard enough. Let me just feel how i feel. You know . You know, let me tell you exactly how i feel without you telling me that i need to be strong. And she was there for that. You must think of her, i guess, often . Oh, yeah, absolutely. Up to today i didnt know what had happened since my last conversation with her. She is really, really, really, really poorly at the moment. But she did record a