What on earth are we doing . Pushing this legislation through over a couple of days. Also on the programme theres to be a Public Inquiry into the Manchester Arena bomb attack, which killed 22 people. A us company says its developed the first drug that can slow down alzheimers disease. And england mind games ahead of the Rugby World Cup semi final. Coach eddiejones says the pressures on the all blacks. And in sport on bbc news after a torrid start to the season for tottenham, can they get back on track in the Champions League later . They host red star belgrade. Good evening from westminster, where in an hours time mps will begin voting on the Prime Ministers brexit deal. If he wins hell be a step closer to delivering his promise of brexit on 31st october. If he loses he could abandon his brexit legislation and push instead for a general election, but whats in the deal mps are voting on shortly . It includes a transition period when the uk will still abide by the eus rules to give time to negotiate a new trade deal. It ensures that eu and uk citizens retain their rights on residency and Social Security and it says the uk will pay around £33 billion to the eu in a so called divorce bill, but it ditches the backstop that was in theresa mays deal and instead essentially draws a new Customs Border in the irish sea. That first vote could be close tonight could be the first time mps actually back a brexit deal but its the second vote on the timetable for passing that legislation that could cause problems. The Prime Minister wants it done in just three days some say its not long enough. If his timetable is rejected, borisjohnson says hell pull the whole bill. Heres our Political Editor laura kuenssberg. Boris editor laura kuenssberg. Johnsons deal, Boris JohnsonsBoris Johnsons deal, Boris Johnsons day. Sweeping to the commons for the first time for mps to vote on the full agreement. Rushing to push it through, but will there be more hiss than speed . called the Prime Minister. And we come together now and the very best traditions of their size door to door coming together . Traditions of their size doortodoor coming together . Chance would be a fine thing. Threatening mps with an election if they dont agree to his timetable tonight and the eu says delay. If parliament refuses to allow brexit to happen and instead gets its way and decides to delay everything untiljanuary or possibly longer, in no circumstances can the government continued with theirs. The bill will have to be pooled and we will have to go forward , pooled and we will have to go forward, much as he may not like it, toa forward, much as he may not like it, to a general election. Labour doesnt believe that threat and could try to block an election a nyway could try to block an election anyway with no intention of backing the agreement with the eu or the rapid timetable to push it through. Page after page of what amounts to nothing worse than a charter for deregulation and a race to the bottom. A deal and a bill that fails to protect our rights and our natural world. Fails to protectjobs and the economy. Fails to protect every region and nation in the united kingdom. None of the opposition parties are on board. Together we can stop brexit and whatever the result is tonight this is not over. This change in this agreement is the most fundamental change to a reunion since the act of union and that merits debate and discussion and this house needs to listen to that. Let this house do itsjob and listen to that. Let this house do its job and rights listen to that. Let this house do itsjob and rights have proper scrutiny over something which is absolutely so fundamental. Inside and outside brexit doesnt split round normal lines. Listen to former tories who will not back it. To see a government with a constitutional measure playing bully boy tactics with this house, it can only be counter productive with this house, it can only be counter productive to the with this house, it can only be counter productive to the very ends of the government itself would like to achieve. Labour then mps pleading with their own leader. Seats that voted very heavily to leave that stood on a manifesto that said that we would respect the result of the referendum feel very strongly that this bill should be allowed to proceed. Theory about the pace and proposals of the Prime Ministers plan matters because borisjohnson is ministers plan matters because Boris Johnson is rising ministers plan matters because borisjohnson is rising as fast ministers plan matters because Boris Johnson is rising as fast as he can against the clock. In theory we could still leave the European Union in nine days. Even though the government has had to ask for the delay didnt want. Do you think the deal will go through tonight . delay didnt want. Do you think the deal will go through tonight . If the laws cannot pass through parliament is up to the eu to decide if there is up to the eu to decide if there isa is up to the eu to decide if there is a delay. They say they hope this is a delay. They say they hope this is the only possible deal and they do not want this dragging on any longer than the uk government. We will always regret the united kingdomto leave the union but at least we can look ourselves in the eye and say that we have done all another power to make sure that this departure is orderly. They must have document . Have you read all the pages . It is a fantastic page turner. Are you hopeful of getting the deal through . A massive change for the whole country and whether this cabinet, best Prime Minister, is willing to risk their shaky grip on power to make it finally come true. So, the first of tonights deciding votes on the brexit deal itself is at around 7pm. The second on the timetable is soon afterwards. In short, we will know tonight whether we leave the eu on halloween. Our deputy Political Editorjohn pienaar looks at what could now happen one way or the other. The government has got a brexit plan, the Withdrawal Agreement bill, and has planned a route, but how far will it get . First, the bill must pass a vote on its broad principles, the second reading its cold, so mps can the second reading its cold, so mps ca n press the second reading its cold, so mps can press on. If the answer is no, journey over, borisjohnson will seek a snap election. If the government when the gets a green light for the first time the journey through parliament gets really tricky. They cannot meet the deadline of october the 31st are mps vote tonight to limit the time for debate and it looks tight. The opposition including the dup, some independent mps, especially former tories, could come together to defeat the government. Boris johnsons big warning as it will not ta ke johnsons big warning as it will not take a long brexit to reoffend when it is offered by the eu. He would drop the bill and challenge the opposition to a snap general election the side of christmas. If the pm wins mps have until thursday to finish their work and send the bill to the lords but the route gets bumpier. A student is coming on whether to hold another referendum that the mps who want as local peoples vote me like the numbers. Some labour mps who want to stay close to the eu via evil tos backlash if the under the brexit referendum. Either way a plan by some brexit critics to keep their uk in what is called the Customs Union could be a bigger obstacle. What is the Customs Union . It is when countries agreed to charge no bar to taxes. They also agree there will be no separate trade deals with countries outside and that is a big pa rt countries outside and that is a big part of the brexit plan. Enough o bsta cles . Part of the brexit plan. Enough obstacles . Not yet. Critics could vote to extend the transition period for as long as it takes to get a Free Trade Agreement with the European Union, so no brexit with no deal. The hardline brexiteers would hate that. A snap election anyone . The brexit journey is hate that. A snap election anyone . The brexitjourney is as tough as ever. Feeling travel sex . Sorry, there is no easy way round. Travel sick . Lets get the latest from laura. Have you any sense of the numbers . It is hard to tell. It is feeling like something that is ebbing and flowing. A lot of mps are agonising over what is the best thing for them to do, whether to try to satisfy their constituents, their party, whether or not the sense of momentum is on their site or not. This is for a lot of mps they know they may not have much public sympathy but it is difficult for them to make these decisions. The conventional wisdom is that the first vote on the second reading, seeing mps do mps think it is worth debating this, that seems more likely than not to go through, but maybe only by a whisker. The second bit about the Prime Ministers timetable, his attempt to get this through at 100 mph, that has been tricky for the government, and i think there it is too close to call. Another is not very long for any of us but an error in the elastic political time is a long time indeed. If both votes fail, and even ifjust the timetable fails, it may be that borisjohnson tries to start a new argument altogether. Whether or not he can persuade the rest of the parliament to go for a general election. It is a cliche but the stakes can hardly be higher. Our europe correspondent adam fleming is in strasbourg, where eu leaders and politicians have been meeting today. Adam, what is being said there . I think they are watching to see what happens where you are tonight because it is a very confusing picture. If there is a need for an extension then the eu would say yes because if they said no they would because if they said no they would be risking an audio brexit and that is the one thing they will do anything to avoid. If there is an extension in an ideal word for the eu it would be a short one, maybe to the middle of next month or two the end of january as the the middle of next month or two the end ofjanuary as the Prime Ministers very unenthusiastic later asked for. If they need more time i have had all sorts of dates, the end of march, the end ofjune, maybe even the end of next year but that is just speculation from diplomats, andi is just speculation from diplomats, and i hope i am making it clear that people here are not sure what is going to happen and they are waiting to see what happens with you in the next couple of hours, but one thing is not going to change, Michel Barnier is staying in the European Commission to oversee whatever happens next. Thats it for now from westminster. Ill be back later in the programme, but now back to clive in the studio. A Public Inquiry will be held into the Manchester Arena bomb attack, which killed 22 people, in may 2017. The home secretary, priti patel says its the best way for those who survived or lost loved ones, to get answers. The announcemernt comes as the younger brother of the bomber, appeared at the old bailey, and pleaded not guilty to murder. Our north of england correspondent, Judith Moritz is at the Manchester Arena for us this evening. Is this what the families and survivors of those who died wanted . It is what they expected because they were due to be inquests in this inquiry will replace those inquests because last month the coroner agreed that the result should be kept secret on the grounds of National Security but he warned it would be difficult to hold an inquest and it was the coroner who asked for a Public Inquiry instead because this may seem like a contradiction but he will be able to hear that evidence himself in private behind closed doors without those families and the public being present. The home secretary said today in granting the inquiry this is an important step for those affected to be able to move on. She knows they want answers as quickly as possible. Having spoken to some of the families and their lawyers they say they are demanding complete candourfrom they say they are demanding complete candour from the authorities and they are frustrated about how low may see this has taken. They want the inquiry to begin as soon as possible but i understand it will not go under way until the completion of criminal proceedings against hashem abedi his trial was due to start injanuary next year and the Public Inquiry will follow one after that. The American Woman who fled the uk, after a fatal road collision with the teenager harry dunn, has asked to be interviewed by British Police in the us. Anne sacoolas is believed to have been driving on the wrong side of the road, when the accident happened in northamptonshire, in august. She later left britain claiming diplomatic immunity, despite telling police she had no immediate plans to return to america. Duncan kennedy reports. He wasjust 19 years he was just 19 years old. Harry dunn died in august, riding his beloved motorbike on a quiet, country road. Since then, his parents charlotte and tim have been everywhere from the white house to whitehall in their efforts to bring the suspect in his case to justice. They say Anne Sacoolas, the driver of the car involved in harrys collision, should return to britain from the United States. Today, the chief co nsta ble of United States. Today, the chief constable of northamptonshire said his officers would go to the us to interview Anne Sacoolas under caution. She wants to meet officers face to face and put her side of the story across and also wants to emphasisejust story across and also wants to emphasise just how devastated she is by all of this. Its nearly eight weeks since harry had his accident ona weeks since harry had his accident on a road in northamptonshire. It was on august the 27th that he died. Three days later, the us embassy told britain that Anne Sacoolas had diplomatic immunity. On the 15th of september, they revealed she had left the uk. Ten days later, Police Confirmed her departure to harrys family. Today, to man charlotte said they were amazed Anne Sacoolas had 110w they were amazed Anne Sacoolas had now offered to be interviewed. Its a huge step in the right direction. Very much so. It feels like that we are finally getting somewhere. We we re are finally getting somewhere. We were surprised, because obviously she left the country and its a complete turnaround for us, really. We we re complete turnaround for us, really. We were not expecting that at all. Police investigating the crash in northamptonshire say they will fly to the United States to interview Anne Sacoolas as soon as their visas are in place. They say they will then bring the information back, handed to the Crown Prosecution Service and it is they who will decide if she is to be charged. Harrys family want the home office to then seek the extradition of Anne Sacoolas. They say it is britain where harry died and a britain where any consequences should be faced. Duncan kennedy, bbc news. An American Pharmaceutical Company says it may have developed the first drug to slow alzheimers disease. The company, biogen, says it will soon seek regulatory approvalfor the drug in the us. Our health and science correspondent, James Gallagher is here. This is the holy grail of Alzheimers Research but there is a long way to go, surely. Exactly. There have been many false dawns before, but there is genuine excitement because what you have to remember is there is no drug that can slow the pace of any dementia, so if this one is capable of doing it in alzheimers, that would genuinely be one of the biggest moments in modern medical research, however the question is, are we there yet. We are not entirely sure we have the answer, so biogn looks at the date and said it didnt work, but now it looked in more detail and its looked at the patients who are getting the highest doses and is there a benefit in terms of memory, language ability and day to day tasks like getting dressed in the morning. So the question now is, what does it really mean . Scientist wa nt to what does it really mean . Scientist want to see the data in much greater levels of detail than they are able to at the moment and only then will they say if this is a turning point or not. Lets take a look at some of the days other top stories. A court has been hearing how the decision to revoke the british citizenship of shamima begum, one of the three Bethnal Green schoolgirls who travelled to syria to join the so called islamic state, has left her at risk of hanging. Her lawyers claim shes in an incredibly fragile and dangerous position in a syrian refugee camp. Ms begum says stripping her of british citizenship leaves her stateless, cotravening, international law. Turkeys president has threatened to resume military action in North Eastern syria, unless kurdish fig