Research finds that the prevalence of antimicrobial resistance (AMR) of uropathogenic Escherichia coli (UPEC) from outpatient uncomplicated UTIs at KPSC has slightly decreased between 2016 and 2021, both for in-person and virtual settings, although the magnitude of the decrease was mostly small. Resistance to penicillins, fluoroquinolones, and TMP-SMX was common.