AB Science SA (Euronext - FR0010557264 - AB) today announces publication of a peer-reviewed article titled ‘ Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2' in the journal Science [1]. The article reports on research that identifies masitinib as a broad antiviral agent capable of treating SARS-CoV-2 (the virus that causes COVID-19), including demonstration of in vivo activity in mice, with efficacy maintained, in vitro, against SARS-CoV-2 variants of concern. This article and its accompanying online supplemental material are accessible online from the journal website: https://science.sciencemag.org/lookup/doi/10.1126/science.abg5827 Research led by Professor Savas Tay and Dr. Nir Drayman from the Pritzker School for Molecular Engineering (University of Chicago, USA) screened a library of 1,900 clinically safe drugs and identified masitinib as the most potent inhibitor of the main target responsible for virus reproduction, a protease called 3CLpro.