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Scientists show immune cells change behavior unexpectedly to instigate psoriasis lesions

 E-Mail Millions of people suffer from psoriasis, a chronic, autoimmune disorder that causes scaly patches on the skin and often precedes psoriatic arthritis. While no cure exists, treatments range from topical creams to injected medications that block inflammation. To improve treatment options, scientists need to better understand the dysregulation of the immune system that leads to these lesions. Using advanced computational genomic analysis of immune cells from mouse models, a researcher at the Pritzker School of Molecular Engineering (PME) at the University of Chicago and her collaborators discovered that, when exposed to a trigger, certain kinds of immune cells change their behavior in unexpected ways to produce the protein signals that cause lesions.

Sunburn — The morning read of what s hot in Florida politics — 5 6 21

Sunburn — The morning read of what’s hot in Florida politics — 5.6.21 Let’s start the morning with some great news about two really good people: Aly is a vice president of Accounts with On3PR, while Omar is deputy chief of staff to Speaker Chris Sprowls. — @NickConfessore: The fact that this private corporate administrative decision is being covered as something akin to a Supreme Court ruling — rightly so, I think — is the best illustration I can imagine of the sheer power Facebook has achieved over the public square — @BostonJoan: Imagine spending millions to offload blame only to have it returned like a bill lost in the mail, which is now overdue.

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