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Record Industry Vet Steve Greenberg Exits S-Curve, BMG
March 5, 2021 at 4:09 PM (PT)
Steve Greenberg
S-CURVE RECORDS founder STEVE GREENBERG, whose musical exploits range from the BAHA MEN s Who Let The Dogs Out and HANSON s MMMBop to BETTY WRIGHT and JOSS STONE, has left BMG and the label he founded in 2000 and sold to the company in 2015.
GREENBERG will continue to manage the sibling pop-rock trio AJR, currently enjoying a huge radio hit with “Bang” and an album release MARCH 26th. That group and all the other artists on the S-CURVE roster will be absorbed by BMG. Among the artists on the roster were ANDY GRAMMER, LESLIE ODOM JR., WE THE KINGS, BAY LEDGES, RACHEL CROW, MAXI PRIEST, HAILEY KNOX, DURAN DURAN, FOUNTAINS OF WAYNE, SARAH HUDSON, TOM JONES, DAVID BROZA, SWAMP DOGG, CARE BEARS ON FIRE and TINTED WINDOWS, the band formed by TAYLOR HANSO
Study improves understanding of the chemistry behind potent antibiotic synthesis
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine.
The antibiotic thiostrepton is very potent against Gram-positive pathogens and can even target certain breast cancer cells in culture. While it has been used topically in veterinary medicine, so far it has been ineffective in humans because it is poorly absorbed. We studied the first steps in thiostrepton s biosynthesis in hopes of eventually being able to hijack certain processes and make analogs of the molecule that might have better medicinal properties. Importantly, this reaction is found in the biosynthesis of numerous other antibiotics, and so the work has the potential to be
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IMAGE: The synthesis of the potent antibiotic thiostrepton uses a radical SAM protein TsrM, whose crystal structure is shown at left while bound to an iron-sulfur cluster and cobalamin. New images. view more
Credit: Booker Lab, Penn State
UNIVERSITY PARK, Pa. Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. The antibiotic thiostrepton is very potent against Gram-positive pathogens and can even target certain breast cancer cells in culture, said Squire Booker, a biochemist at Penn State and investigator with the Howard Hughes Medical Institute. While it has been used topically in veterinary medicine, so far it has been ineffective in humans because it is poorly absorbed. We studied
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