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Immune Cells in Cerebrospinal Fluid Predict Response of Brain Metastasis to Immunotherapy March 9, 2021 Studies by researchers at the Vall d’Hebron Institute of Oncology (VHIO), and the National Centre for Genomic Analysis-Centre for Genomic Regulation (CNAG-CRG), Barcelona, have demonstrated how immune cells that access the cerebrospinal fluid (CSF) of patients with brain metastases faithfully recapitulate the characteristics of the brain tumor immune cells, and could represent novel biomarkers of response to immune checkpoint inhibitor (ICI) therapy. The team used single-cell RNA sequencing combined with T cell receptor genotyping to characterize immune cells in brain lesions and matched CSF. The single-cell profiling allowed them to chart the major cell types and transient tumor-sepcific states in the brain metastasis (BrM) tumor microenvironment (TME). Describing their results in

Israel generalComunidad autonoma de catalunaJoan seoaneHolger heynSingle cell genomics teamNature communicationsNational centre for genomic analysisHebron institute of oncologyCentre for genomic regulationHebron university hospitalTranslational researchHebron instituteNational centreGenomic analysis centreGenomic regulationCell genomics team