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Immune Cells in Brain Predict Response to Immunotherapy by Angela Mohan on  March 8, 2021 at 6:18 PM Immune cells accessing cerebrospinal fluid recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies, as per the study in Nature Communications, led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor. Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and anti-CTLA4, have shown significant clinical benefits in patients with progressive or metastatic solid tumors, including some brain metastasis. Notably, these immune-based therapies have improved outcomes for some of those suffering from lung cancer and melanoma. Together, these tumor types (represent between 30-40% of all cancers), along with breast cancer, are three common malignancies that lead to brain metastases.

Comunidad autonoma de catalunaJoan seoaneHolger heynSingle cell genomics teamNature communicationsNational centre for genomic analysisCentre for genomic regulationHebron university hospitalTranslational researchNeurosurgery servicesCorresponding authorNational centreGenomic analysis centreGenomic regulationCell genomics teamIntelligence quotient