Only an anthropologist would treasure millennia-old human feces found in dry caves.
Just ask Dr. Meradeth Snow, a University of Montana researcher and co-chair of UM’s Department of Anthropology. She is part of an international team, led by the Harvard Medical School-affiliated Joslin Diabetes Center, that used human “paleofeces” to discover that ancient people had far different microorganisms living in their guts than we do in modern times.
Snow said studying the gut microbes found in the ancient fecal material may offer clues to combat diseases like diabetes that afflict people living in today’s industrialized societies.
Dr. Meradeth Snow
Ancient people had far different microorganisms in their guts than modern humans
Only an anthropologist would treasure millennia-old human feces found in dry caves. Just ask Dr. Meradeth Snow, a University of Montana researcher and co-chair of UM s Department of Anthropology.
She is part of an international team, led by the Harvard Medical School-affiliated Joslin Diabetes Center, that used human paleofeces to discover that ancient people had far different microorganisms living in their guts than we do in modern times.
Snow said studying the gut microbes found in the ancient fecal material may offer clues to combat diseases like diabetes that afflict people living in today s industrialized societies.
The University of Montana
Only an anthropologist would treasure millennia-old human feces found in dry caves.
Just ask Dr. Meradeth Snow, a University of Montana researcher and co-chair of UM’s Department of Anthropology. She is part of an international team, led by the Harvard Medical School-affiliated Joslin Diabetes Center, that used human “paleofeces” to discover that ancient people had far different microorganisms living in their guts than we do in modern times.
Snow said studying the gut microbes found in the ancient fecal material may offer clues to combat diseases like diabetes that afflict people living in today’s industrialized societies.
The work could lead to new immunotherapy treatments.
The immune system fights bacteria, viruses, and other pathogens by utilizing several types of T cells, all of which have receptors that are specific to particular antigens. On killer T cells, the receptor works in concert with three signaling modules and a coreceptor to destroy the infected cell.
“When we saw that the 5MCAR T cells completely eliminated the harmful T cells that invaded the pancreas, we were blown away.”
The researchers copied the evolutionary design to engineer a five-module chimeric antigen receptor, or 5MCAR, T cell.
“The 5MCAR was an attempt to figure out if we could build something by biomimicry, using some of evolution’s natural pieces, and redirect T cells to do what we want them to do. We engineered a 5MCAR that would direct killer T cells to target autoimmune T cells that mediate type 1 diabetes,” says Michael Kuhns, an associate professor in the immunobiology department at the University of A