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Study shows how mutant huntingtin protein triggers brain cell death In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington s disease, raising high hopes for a quick cure. Yet today, there s still no approved treatment. One difficulty has been a limited understanding of how the mutant huntingtin protein sets off brain cell death, says neuroscientist Srinivasa Subramaniam, Ph.D., of Scripps Research, Florida. In a new study published in Nature Communications on Friday, Subramaniam s group has shown that the mutated huntingtin protein slows brain cells protein-building machines, called ribosomes. The ribosome has to keep moving along to build the proteins, but in Huntington s disease, the ribosome is slowed. The difference maybe two, three, four-fold slower. That makes all the difference.

United statesSrinivasa subramaniamEmily hendersonScripps researchScripps research instituteNature communications onNature communicationsHuntington 39s diseaseBrain cellCell deathProtein synthesisஒன்றுபட்டது மாநிலங்களில்ஸ்ரீநிவாச சுப்ரமணியம்எமிலி ஹென்டர்சன்ஸ்கிரிப்ட்கள் ஆராய்ச்சிஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம்