Exposure to endocrine-disrupting chemicals may increase likelihood of postpartum depression
Endocrine-disrupting chemicals may influence hormonal shifts during pregnancy as well as contribute to postpartum depression, according to a small study published in the Endocrine Society s
Journal of Clinical Endocrinology & Metabolism.
Postpartum depression is a serious and common psychiatric disorder that affects up to 1 in 5 childbearing women. The cause of postpartum depression is not well understood, but hormonal changes during pregnancy have been found to be an important factor. Harmful chemicals such as bisphenols and phthalates that are found in plastics and personal care products are known to affect sex hormones.
Researchers reveal novel therapeutic target in the treatment of certain cancers
Mount Sinai Researchers Find Removal of AKAP11 Protein by Autophagy as a key to Fuel Mitochondrial Metabolism and Tumor Cell Growth through activating protein kinase A (PKA) (Patent pending)
Corresponding Author: Zhenyu Yue, PhD, Professor of Neurology, Aidekman Family Professorship, Director of Basic and Translational Research in Movement Disorders, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai.
Bottom Line: We uncovered a mechanism that tumor cells exploit selective autophagy for metabolic reprogramming that benefits tumor cell growth and offers resistance to glucose deprivation. Our study suggests that AKAP220-mediated autophagy as a novel therapeutic target for specific cancer treatment.
Amino acids signaling controls whole-body glucose homeostasis, study shows
Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells. Amino acids have also recently been recognized as chemical signals that control cell growth and metabolism. Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism s genes is made inoperative, known as genetic knockout. Steven Zheng, PhD, chief of Cancer Pharmacology and researcher at Rutgers Cancer Institute is senior author of the work and shares more about the findings published in the March 16 online edition of
Women who are fit and healthy tend to burn more fat when they exercise
Females who are fit and healthy tend to burn more fat when they exercise than men, according to new research from a team of sports nutritionists.
The research, comprising two new studies from academics led by the University of Bath s Centre for Nutrition, Exercise & Metabolism, analysed the factors that most influenced individuals capacity to burn body fat when undertaking endurance sports.
How the body burns fat is important to all of us for good metabolic health, insulin sensitivity and in reducing the risk of developing Type II diabetes. But, for endurance sport competitions, such as running or cycling, how the body burns fat can make the difference between success and failure.
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Electromagnetic fields hinder spread of breast cancer, study shows
Electricity may slow – and in some cases, stop – the speed at which breast cancer cells spread through the body, a new study indicates.
The research also found that electromagnetic fields might hinder the amount of breast cancer cells that spread. The findings, published recently in the journal Bioelectricity, suggest that electromagnetic fields might be a useful tool in fighting cancers that are highly metastatic, which means they are likely to spread to other parts of the body, the authors said.
“We think we can hinder metastasis by applying these fields, but we also think it may be possible to even destroy tumors using this approach,” said Vish Subramaniam, senior author of the paper and former professor of mechanical and aerospace engineering at The Ohio State University. Subramaniam retired from Ohio State in December.