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What Are Puberty Blockers? Recent conservative legislation has targeted a class of drugs used to treat transgender adolescents. But what do these drugs actually do? Sebastian Liafsha, right, with his mother, Heather, of Lexington, S.C., used puberty blockers starting at age 14.Credit.Leslie Ryann McKellar for The New York Times When Sebastian Liafsha came out as transgender in middle school, his mother, Heather, jumped into research mode. Ms. Liafsha, a registered nurse in Lexington, S.C., put together a three-inch-thick binder packed with printouts of various laws, medical guidelines, pharmaceutical records and more. It was there that she would record the dates and details of Sebastian’s puberty blocker injections every three months for two and a half years, starting at age 14.

New yorkUnited statesAsa hutchinsonLeslie ryann mckellarStephen rosenthalSebastian liafshaJessica kremenAmerican academy of pediatricsNew york timesWorld professional association for transgender healthEndocrine societyDrug administrationBoston children hospital gender multispecialty serviceAmerican academyBoston childrenGender multispecialty service