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© NATALLIA YATSKOVA/ISTOCK.COM, In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger. Contrary to established dogma, the spleen is not the principal source of the pro-inflammatory cytokine called tumor necrosis factor (TNF), which drives the sort of system-wide inflammation seen in sepsis. A paper in Science Signaling last week (April 20) reports that the liver and lungs of rats produce more TNF than the spleen does, but the spleen remains the master regulator, of the liver at least, instructing the nearby organ, via lipid signals, on how much TNF to make.

Kevin traceyAlexandre steinerHenrique serezaniVanderbilt universityDuke university luis ulloaFeinstein institutes for medical researchScience signalingLuis ulloaFeinstein institutesMedical researchகெவின் ட்ரேசிஅலெக்ஸாண்ட்ரே ஸ்டீனர்வாண்டர்பில்ட் பல்கலைக்கழகம்ஃபைன்ஸ்டீன் நிறுவனங்கள் க்கு மருத்துவ ஆராய்ச்சிஅறிவியல் சமிக்ஞைலூயிஸ் யூலோவ