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Zwelethu: Our Land — A story of struggle, conflict an

Zwelethu: Our Land — A story of struggle, conflict an
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Turing Oversold

Turing Oversold
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1931: Theoretical Computer Science & AI Theory Founded by Goedel

1931: Theoretical Computer Science & AI Theory Founded by Goedel
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NIMH » Past Research

Psychosocial Stress, Environmental Enrichment, and Hippocampal Neurogenesis A naturalistic model of chronic stress that mimics depressive conditions in humans is psychosocial stress, achieved in mice by creating a housing condition in which an aggressive dominant mouse and a subordinate mouse live together separated by a perforated barrier. The persistent conflict results in socially defeated subordinate mice that show behavioral signs of increased anxiety, helplessness, anhedonia, and inappropriate social interaction, assessed in validated behavioral tests. We showed that environmental enrichment housing in large cages with tubes, toys, and a running wheel following social defeat restores the normal behavior of the subordinate mice. We found that adult neurogenesis is required for the restorative effects. We also found that the environmental enrichment is protective when it is given prior to the psychosocial stress, and these effects are neurogenesis-dependent and require norma

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