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Good morning, it’s Monday, May 3, 2021. Over the weekend, Illinois Rep. Cheri Bustos became the latest swing district Democrat to announce her impending retirement. Then, Texas Democrats in a district southwest of Fort Worth splintered their vote, thereby botching any chance they had of picking up a House seat in a special election.
In non-political news, a horse named Medina Spirit won the Kentucky Derby, a record seventh time trainer Bob Baffert has won the “Run for the Roses.” Baffert’s horse won in 2020, too, and with the same rider John Velazquez who was in the winner’s circle on Saturday. This was the fourth Derby win for Johnny V.
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IMAGE: Human enzyme METTL3 adds methyl groups to introduce m6A in SARS-CoV-2 s RNA. That modification prevents the virus RNA from triggering inflammatory molecules known as cytokines. METTL3 also leads to increased. view more
Credit: UC San Diego Health Sciences
Researchers at University of California San Diego School of Medicine have discovered one way in which SARS-CoV-2, the coronavirus that causes COVID-19, hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease.
In short, the virus genome gets tagged with a special marker by a human enzyme that tells the immune system to stand down, while at the same time ramping up production of the surface proteins that SARS-CoV-2 uses as a doorknob to enter cells.
News release
Researchers at University of California San Diego School of Medicine have discovered one way in which SARS-CoV-2, the coronavirus that causes COVID-19, hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease.
In short, the virus’ genome gets tagged with a special marker by a human enzyme that tells the immune system to stand down, while at the same time ramping up production of the surface proteins that SARS-CoV-2 uses as a “doorknob” to enter cells.
The study, published April 22, 2021 in
Cell Reports, helps lay the groundwork for new anti-viral immunotherapies treatments that work by boosting a patient’s immune system, rather than directly killing the virus.
While the documentary will undoubtedly focus on many important aspects of Hemingway’s life and work, it is my hope that it will spend sufficient time emphasizing something that gets lost in Hemingway hagiography and myth-spinning his tireless discipline with the craft of writing