Researchers study the behavior of regulatory T cells to understand periodontal disease
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don t understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?
In a paper published recently in
Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. Looking at periodontal disease in a mouse model, scientists found that a specific type of T cell, known as regulatory T cells, start behaving in unexpected ways. These cells lose their ability to regulate bone loss and instead begin promoting inflammation.
E-Mail
IMAGE: Dr. Carla Alvarez, a postdoctoral researcher at Forsyth and lead author of the paper. view more
Credit: Matthew Modoono/Forsyth Institute
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don t understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?
In a paper published recently in
Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. Looking at periodontal disease in a mouse model, scientists found that a specific type of T cell, known as regulatory T cells, start behaving in unexpected ways. These cells lose their ability to regulate bone loss and instead begin promoting inflammation.
Santos deny that Messi has broken Pele s record!
BeSoccer 3 months ago
Santos claim that Pele scored over 1000 goals for them. EFE A statement on Santos official website criticises the fact that only goals scored in official tournaments count towards the number of goals scored. They say that Pele has actually scored 1091 goals for Santos if you include all of the matches.
Santos do not agree
Santos investigators and historians association do not agree with it.
This group, under the signature of Fernando Ribeiro,
issued a statement on the club s official website in which they deny that the Brazilian star only scored 643 goals for Santos.
Messi s Barcelona record disputed by Santos: Pele scored 1,091
play
Why are Santos disputing Messi breaking Pele s record? (1:18)
Gab Marcotti explains Santos claims that Lionel Messi did not break Pele s record of most goals for one club. (1:18)
Pele s total for Santos, recognised by many as 643, was considered the most by any player at a single club until Messi scored his 644th for Barca during a 3-0 win over Real Valladolid.
Three-time World Cup winner Pele even congratulated Messi, but Santos claimed in an Instagram post that goals by their former player in prestigious friendlies should count towards his overall total. In the last few days, there has been a lot of talk in the media and on social media about how many goals Pele scored in a Santos shirt, a post on the club s Instagram page read.
A photo combination of Pele and Lionel Messi created on December 28, 2020.
Lionel Messi hit a historic landmark recently when he scored his 644th goal for Barcelona against Real Valladolid in La Liga, surpassing Pelé as the player with the most goals scored for a single club.
However, Brazilian football club Santos, in a statement released on Saturday, claimed that Messi is yet to surpass its legend’s record.
Santos put Pele’s total goal haul at 1,091.
There has been a lot of controversy about how many goals the all-time leading goal scorer for Brazil actually scored for Santos. While he has been credited with 643 goals for the Brazilian club Pele has claimed in the past that he scored over 1,000.