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Kidney cancer treatments: Controlling cholesterol may key to treating clear cell renal cell carcinoma
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Penn Study Finds New Possible Cell Target to Treat Clear Cell Renal Cell Carcinoma
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Penn study discovers a targetable vulnerability in clear cell renal cell carcinoma
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Four Penn faculty elected to the National Academy of Sciences The new members of the Academy, honored scholars recognized for their unique and ongoing contributions to original research, include researchers from the Perelman School of Medicine, School of Engineering and Applied Science, and Annenberg School for Communication. As newly elected members of the U.S. National Academy of Sciences, (clockwise from top left) Marisa Bartolomei and M. Celeste Simon from the Perelman School of Medicine, Michael Kearns from the School of Engineering and Applied Science, and Diana C. Mutz from the Annenberg School for Communication join a class of honored scholars recognized for their unique and ongoing contributions to original research.
Credit: The Wistar Institute
PHILADELPHIA (April 1, 2021 Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment. The study, published in
Nature Cell Biology, reports that methyltransferase-like 3 (METTL3) and 14 (METTL14) proteins moonlight as transcriptional regulators that allow for establishment of the senescence-associated secretory phenotype (SASP).
Cellular senescence is a stable state of growth arrest in which cells stop dividing but remain viable and produce an array of inflammatory and growth-promoting molecules collectively defined as SASP. These molecules account for the complex crosstalk between senescent cells and neighboring cells and the effect of cellular senescence in various physiological processes and diseases. Although senescence is regarded as a potent barrier for tum