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Exploring COVID-19 Immune Responses Using Flow Cytometry
Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and continues to affect millions across the world. Disease severity varies with some patients requiring mechanical ventilation, and the mortality rate is thought to be as high as 10%. Several studies have used flow cytometry to investigate how the immune system reacts to SARS-CoV-2.
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What did the immune profiling of hospitalized patients reveal?
Research revealed that dysregulation of the immune system was linked to the pathogenesis of COVID-19. However, the role remained unclear. Matthew et al. carried out an observational study to investigate the immune response to SARS-CoV-2. The cohort included adults hospitalized with COVID-19 (COVID-19 patients), adults who had COVID-19 (recovered donors) but were not hospitalized, and volunteers who had not had COVID-19 (health