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Shelter Island Reporter Letters to the Editor: June 3-10 - Shelter Island Reporter

Shelter Island Reporter Letters to the Editor: June 3-10 - Shelter Island Reporter
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Study quantifies how many children in the U.S. have lost a parent during Covid-19 pandemic

Study quantifies how many children in the U.S. have lost a parent during Covid-19 pandemic A letter published in JAMA Pediatrics, co-authored by Rachel Kidman, PhD, of the Program in Public Health at Stony Brook University, presents a statistical model showing that around 40,000 children (est. between 37,000 and 43,000) had lost a parent due to the Covid-19 pandemic by February 2021. This amounts to an average of one child losing a parent for every 13 Covid-19 deaths. Children face immense challenges in the wake of the pandemic. While there have been anecdotal reports of children losing parents, this is the first study to estimate the increase in orphan rates nationwide. The authors also published an Op Ed in the

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40K kids in the US may have lost a parent to COVID-19

Approximately 40,000 children in the United States may have lost a parent to COVID-19 since February 2020, according to a statistical model. The researchers anticipate that without immediate interventions, the trauma from losing a parent could cast a shadow of mental health and economic problems well into the future for this vulnerable population. In the researchers’ model, for approximately every 13th COVID-related death, a child loses one parent. Children who lose a parent have a higher risk of a range of problems, including traumatic prolonged grief and depression, lower educational attainment, economic insecurity, and accidental death or suicide, says Ashton Verdery, associate professor of sociology, demography, and social data analytics at Penn State.

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KRAS gene may drive immune 'evasion' in pancreatic cancer

These mutations occur in more than 90% of pancreatic cancer cases and drastically reduce response to immunotherapy. A new study in Nature Communications takes an initial step toward better understanding how KRAS drives immune evasion and demonstrates a lowering of the KRAS activity resulting in a more favorable immune environment to fight cancer. Previous strategies to block the KRAS oncogene therapeutically have focused on counteracting its growth-promoting role in cancer. “Instead, our study shows that oncogenic KRAS plays a profound immunosuppressive role in cancer maintenance, and that treatment of cancer will be improved by simultaneously inhibiting KRAS and activating immune pathways suppressed by the cancer,” says Oleksi Petrenko, research assistant professor in the department of microbiology and immunology in the Renaissance School of Medicine at Stony Brook University.

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