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Benny Landsman, 4, at Dayton Children’s Hospital April 8, 2021, before surgery to receive the first clinical trial of a new gene therapy for Canavan disease. (Courtesy of the Landsman family/ via Dayton Jewish Observer)
Benny Landsman, 4, is prepped for surgery at Dayton Children’s Hospital, April 8, 2021. (Courtesy of the Landsman family/ via Dayton Jewish Observer)
Benny Landsman with Paola Leone and Dr. Christopher G. Janson at Dayton Children’s Hospital, April 8, 2021. (Courtesy of the Landsman family/ via Dayton Jewish Observer)
Jordana Holovach with her late son, Jacob, who died of Canavan disease at age 19. (Courtesy of Jordana Holovach/ via Dayton Jewish Observer)
By Marshall Weiss, The Dayton Jewish Observer (reprinted with permission) | May 06, 2021
In an operating room at Dayton Children’s Hospital on April 8, 4-year-old Benny Landsman of Brooklyn received the first new clinical trial of an FDA-approved gene therapy for Canavan disease.
Neurosurgeon Dr. Robert Lober placed four catheters in holes drilled into Benny’s skull, down a track to a fluid space in the brain’s ventricles. Lober then manually injected a fluid containing 370 trillion viral genomes of the new therapy.
By his side in the operating room were the trial’s clinical leader, Dr. Christopher G. Janson, also with Dayton Children’s and Premier Health’s Clinical Neuroscience Institute, and longtime Canavan researcher Paola Leone, professor of cell biology at Rowan University in Glassboro, New Jersey, and director of Rowan’s Cell and Gene Therapy Center.
While the Landsman family is optimistic that the gene therapy will help their two sons, they also hope it will help families not receive same dire prognosis.
Alzheimer’s Association presenting special education programs
DAYTON People in the Miami Valley will have an opportunity to ask a neurologist questions and attend dementia education programs on a Saturday this month as part of special programming by the Alzheimer’s Association Miami Valley Chapter.
Dr. Christopher Janson, who leads the Cognitive Clinic at the Clinical Neuroscience Institute, will answer questions and present on Understanding Alzheimer’s and Dementia 4:30-5:30 p.m. Thursday, Feb. 25 during a webinar event. Janson, who is a memory specialist, will provide insight into recognizing problematic memory changes, what to expect during the dementia assessment and the specific questions a good assessment can answer. The session, which is free, will be conducted via Zoom. To attend, call 800-272-3900 to register and the Zoom link will be provided.