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Turning a pancreatic cancer cell s addiction into a death sentence

E-Mail IMAGE: Senior author and Princess Margaret Scientist Dr. Marianne Koritzinsky s research reveals the potential of targeted therapies to exploit unique metabolic features of pancreatic cancer cells. view more Credit: Visual Services, UHN (Toronto, Friday, May 7, 2021) Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre (PM) Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or addicted to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell.

United statesAlexandra radkewyczMarianne koritzinskyPionyr immunotherapeuticsBradlyg woutersDavid hedleyJason moffatPaulc boutrosUniversity health networkScientific advisory boards of biosymetrics incMichener institute for educationTerry fox foundation research instituteSenior public affairs advisorUniversity of torontoAmerican association for the advancement of scienceInstitute of medical science

Ashkenas and Woodgett: Why experts changed the vaccine dosage schedule

Ashkenas and Woodgett: Why experts changed the vaccine dosage schedule
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Bonnie henryAstrazeneca vaxzevriaJimr woodgettJohn ashkenasBc healthLunenfeld tanenbaum research instituteNational advisory committee on immunizationDepartment of medical biophysicsUniversity of torontoPostmedia network incHealth canadaWhy canadaNational advisory committeeOfficer bonnie henryMedical biophysicsPostmedia network

Letters to the editor: Uniting Conservatives is like herding cats

Letters to the editor: Uniting Conservatives is like herding cats National Post © Provided by National Post A man is silhouetted walking past a Conservative party logo before the opening of the party s national convention in Halifax, in 2018. ‘Right-wing divisions run deep and can’t be reconciled within one party’ The Conservative party tries to be a home for everyone on the political right. That is an impossible mandate as it includes a very wide range of interpretations of what “on the right” means. Right-wing divisions run deep and can’t be reconciled within one party. There are Red Tories, centre-right moderates, fiscal conservatives, social conservatives, xenophobic nativists, and climate-change deniers or believers.

British columbiaJean seelyLarry baswickSteven narodReiner jaaksonMeng wanzhouDaniel kowbellJustin trudeauMartinj yaffeBernie madoffMike kennedyTerence corcoranPaula gordonHerb schultzJamesp crowleyHarjit sajjan

Transforming immune killer T-cells into super soldiers to fight against cancer

Transforming immune killer T-cells into super soldiers to fight against cancer Creating super soldiers of specific white blood cells to boost an anti-tumor response has been shown in a series of elegant experiments by Princess Margaret researchers. Research led by Ph.D. candidate Helen Loo Yau, Post-doctoral fellow Dr. Emma Bell and Senior Scientist Dr. Daniel D. De Carvalho describes a DNA modifying epigenetic therapy that can transform immune killer T-cells into super soldiers by boosting their ability to kill cancer cells. Their findings could potentially enhance immunotherapy, a new paradigm in cancer treatment currently effective for a minority of cancer patients. Some patients respond well to immunotherapy, with their tumours drastically shrinking in size, but others respond only partially or not at all. Clinicians and scientists around the world are working to understand why immunotherapy only helps some patients.

Emma bellEmily hendersonUniversity of torontoDepartment of medical biophysicsPrincess margaretHelen loo yauSenior scientistMolecular cellAssociate professorMedical biophysicsCancer treatmentT cellஎம்மா மணிஎமிலி ஹென்டர்சன்பல்கலைக்கழகம் ஆஃப் டொராண்டோதுறை ஆஃப் மருத்துவ உயிர் இயற்பியல்

Turbocharging the killing power of immune cells against cancer

Turbocharging the killing power of immune cells against cancer
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Alexandra radkewyczEmma bellJohn staggChristian kleinUniversity health networkPrincess margaret cancer foundationTerry fox research instituteMichener institute for educationDnamx incDepartment of medical biophysicsCanadian institutes of health researchSenior public affairs advisorPrincess margaret cancer centreUniversity of torontoScotiabank research chairCanadian cancer society innovation award