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High glucose levels, even in the normoglycemic range, may potentiate microvascular complications.    Hyperglycemia can lead to a multitude of health complications. In persons with diabetes, and even in those without, it has been observed to lead to ischemic heart disease. Also, in people with diabetes, a high glucose level is a definitive risk factor for microvascular disease. Although this is known, it is uncertain if hyperglycemia increases the risk of peripheral micro- and macrovascular diseases in the general population. Additionally, it is unknown whether the extent of this same risk varies between vascular compartments.      Previous studies have found complications of microvascular dysfunction in people with prediabetes, such as retinopathy and neuropathy. However, these findings can be misleading due to the accompanying cardiometabolic risk factors such as obesity, hyperlipidemia, and hypertension.    

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