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Scientists from Nanjing University and University of Macau have discovered nano-scaled apoptotic bodies (ABs) as a new brain-targeting drug carrier, bringing new promise for the Parkinson s Disease as well as other brain diseases.
The blood-brain barrier (BBB) is the most restrictive barrier that keeps most biomolecules and drugs from the brain, setting barriers for the treatment of cerebrovascular diseases. With the increasingly serious ageing problem, the treatment of brain diseases now faces tough challenges, and therefore efficient brain drug delivery strategies are urgently needed.
Apoptotic bodies (ABs), secreted from dying cells, have been discovered for half a century but their roles are underestimated. ABs are rarely considered for drug delivery, due to their uneven size distribution (varying from hundreds to thousands of nanometres) and complex composition (especially large chromosomal DNA fragments and various kinds of cytoplasmic proteins). However, with t