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How is Genetic Therapy Advancing?

How is Genetic Therapy Advancing?
labmate-online.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from labmate-online.com Daily Mail and Mail on Sunday newspapers.

City ofUnited kingdomSally ann cryanDavid graingerSonia gandhiIntegrative synthetic biology centre in warwickCancer genomics laboratoryUniversity of birminghamFrancis crick instituteRoyal college of surgeonsDrug deliveryRoyal collegeIntegrative synthetic biology centrePeter van looGenetic mapநகரம் ஆஃப்

Study highlights Evolutionary Aspect of Tumour Development

Study highlights Evolutionary Aspect of Tumour Development
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United kingdomUnited statesMaxime tarabichiBroad instituteUniversity of texas md anderson cancer centerBig data institute at university of oxfordWellcome sanger instituteUniversity of torontoCancer genomics laboratoryCancer research united kingdomBiomedical research centreOntario institute for cancer researchFrancis crick instituteVector instituteUniversity of leuvenIvan loo

Genomic study points to new treatment approaches for advanced small-cell lung cancer

E-Mail COLUMBUS, Ohio - A new study of advanced small-cell lung cancer (SCLC) led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has identified molecular patterns linked to patients developing resistance to certain therapies. This study, published in the journal JTO Clinical and Research Reports, examined more than 60 tumors from five patients. OSUCCC - James researchers identified distinct mutational and molecular changes in four SCLC subtypes. The findings provide new insights into the patterns treatment resistance and could offer new targets for the development of more effective immunotherapy and other therapies for advanced SCLC, which progresses quickly and is usually fatal.

United statesOhio state universityRussell bonnevilleAnoosha paruchuriAmym smithPatricia allenbyGregory ottersonArthurg jamesLianbo yuThuy daoAharong freudSharon coleMelaniea krookHui zi chenEric samorodnitskyWalter wang

Patchwork tumors prevalent across multiple cancer types

E-Mail Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analysed the whole genomes of tumour samples from over 2,600 patients with different types of cancer. They identified a high prevalence of genetic diversity within individual tumours, which they further characterised. Their findings confirm that, even at late stages of development, tumour evolution is driven by changes that benefit the cancer. When cancer cells divide, errors occur in the process of copying their DNA. These copying errors mean that different tumours can be made up of cells presenting a wide range of genetic diversity. This variation is a challenge for doctors as a treatment that works for one group of genetically related tumour cells, called a subclone, may not be effective against another. And certain subclones can initiate tumour spread or drug resistance.

United kingdomUnited statesCity ofMaxime tarabichiRobert waley cohenUniversity college londonBroad instituteKing college londonCancer analysis of whole genomes consortiumUniversity of torontoCancer genomics laboratoryImperial college londonWinton group leaderOntario institute for cancer researchResearch councilUniversity of texas md anderson cancer center

Genetic diversity within tumors suggests continuous evolution

Date Time Genetic diversity within tumors suggests continuous evolution By analyzing tumors from more than 2,600 patients and from 38 cancer types, researchers from The University of Texas MD Anderson Cancer Center and fellow member institutions of the international Pan-Cancer Analysis of Whole Genomes Consortium have characterized the extensive genetic diversity across cancer and within individual tumors. The study, published today in Cell, found that 95% of the analyzed tumors had at least one subclone, or genetically distinct group of tumor cells, and these subclones were often very diverse – even in the same tumor. The findings suggest that tumors continue to evolve in ways that help the cancer survive.

New yorkUnited statesMemorial sloan kettering cancer centerUnited kingdomQuaidd morrisWenyi wangUniversity of texas md anderson cancer centerUniversity of oxfordMd anderson moon shots programCancer analysis of whole genomes consortiumUniversity of torontoCancer genomics laboratoryFrancis crick instituteCancer centerPan cancer analysisWhole genomes consortium