A new Presidential Commission on Supreme Court Reform will be co-chaired by Leighton Homer Surbeck Professor of Law Professor Cristina Rodríguez ’00 and includes a total of 13 Yale Law School faculty and alumni.
President Joe Biden announced his intent to nominate 11 members of his Administration to lead on national security and law enforcement at White House and across key agencies.
Christy Abizaid DOD
The President has tapped Christy Abizaid for Director of National Counterterrorism Center at the Office of the Director of National Intelligence, Chris Inglis for National Cyber Director in the Executive Office of the President, Christine Wormuth for Secretary of the Army at the Department of Defense, Gil Cisneros for Under Secretary of Defense, Personnel and Readiness at the Department of Defense, Anne Milgram for Administrator of the Drug Enforcement Administration at Department of Justice, Susanna Blume for Director of Cost Assessment and Program Evaluation at the Department of Defense, Marcela Escobari for Assistant Administrator for Latin America and the Caribbean at USAID, C.S. Eliot Kang for Assistant Secretary of State for International Security and Non-Proliferation at the Depa
Researchers from North Carolina State University have found a way to fine-tune the molecular assembly line that creates antibiotics via engineered biosynthesis.
by Tracey Peake April 14, 2021 .
RALEIGH – Bacteria – such as E. coli – harness biosynthesis to create molecules that are difficult to make artificially.
“We already use bacteria to make a number of drugs for us,” says Edward Kalkreuter, former graduate student at NC State and lead author of a paper describing the research. “But we also want to make alterations to these compounds; for example, there’s a lot of drug resistance to erythromycin. Being able to make molecules with similar activity but improved efficacy against resistance is the general goal.”
Picture an automobile assembly line: each stop along the line features a robot that chooses a particular piece of the car and adds it to the whole. Now substitute erythromycin for the car, and an acyltransferase (AT) – an enzyme – as the robot at the stations along the assembly line. Each AT “robot” will select a chemical block, or extender unit, to add to the molecule. At each station the AT robot has
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Researchers Streamline Molecular Assembly Line to Design, Test Drug Compounds
Researchers from North Carolina State University have found a way to fine-tune the molecular assembly line that creates antibiotics via engineered biosynthesis. The work could allow scientists to improve existing antibiotics as well as design new drug candidates quickly and efficiently.
Bacteria – such as E. coli – harness biosynthesis to create molecules that are difficult to make artificially.
“We already use bacteria to make a number of drugs for us,” says Edward Kalkreuter, former graduate student at NC State and lead author of a paper describing the research. “But we also want to make alterations to these compounds; for example, there’s a lot of drug resistance to erythromycin. Being able to make molecules with similar activity but improved efficacy against resistance is the general goal.”