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 E-Mail IMAGE: Charu Aggarwal, MD, MPH (top), Ronac Mamtani, MD, (bottom left), and Lova Sun, MD. view more  Credit: Penn Medicine PHILADELPHIA Real-word evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer, according to research from the Abramson Cancer Center at the University of Pennsylvania. In a new study published online today in JAMA Oncology, researchers show that patients harboring a KRAS gene mutation with high levels of PDL-1 lived longer when treated with immunotherapy alone, compared to patients without this mutation. This survival difference by KRAS status was not seen, however, in patients treated with both chemotherapy and immunotherapy, suggesting combination therapy for patients without the mutation may be preferred.

University of pennsylvaniaUnited statesCharu aggarwalLova sunRogerb cohenCoreyj langerRonac mamtaniPerelman school of medicineAbramson cancer centerFlatiron healthPerelman schoolAssociate professorLung cancer excellenceMiles tanMedicine healthClinical trials