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Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of defense cells that persist even after the patient is discharged from hospital. This cellular reprogramming creates a disorder the authors call post-sepsis syndrome, whose symptoms include frequent reinfections, cardiovascular alterations, cognitive disabilities, declining physical functions, and poor quality of life. The phenomenon explains why so many patients who survive sepsis die sooner after hospital discharge than patients with other diseases or suffer from post-sepsis syndrome, immunosuppression and chronic inflammation. The article presents a review of studies conducted to investigate cases of septic patients who died up to five years after being discharged from hospital.

Marcel cerqueira cesar machadoFrancisco garcia sorianoRaquel bragante gritteTalita souza siqueiraUniversity hospitalPaulo research foundationButantan instituteCruzeiro do sul universityWorld health organizationSepsis prevalence assessment databaseMosul universityFrancisco garciaRui curiபல்கலைக்கழகம் மருத்துவமனைபாலொ ஆராய்ச்சி அடித்தளம்புத்தாண்தான் நிறுவனம்