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This article is a collaboration between MedPage Today and: Current smoking was linked with an increased likelihood of a severe phenotype of Crohn s disease after adjustment for the use of biologic therapy, Canadian researchers reported. In a multivariate analysis, the use of biologic therapy was associated with an elevated risk of severe disease phenotype, with an odds ratio of 2.137 (95% CI 1.471-3.106), but after adjustment for biologic use, the risk for smokers for severe disease was almost twofold higher (OR 1.930, 95% CI 1.112-3.350) compared with nonsmokers or former smokers, according to Neeraj Narula, MD, of the University of Ottawa, and colleagues. Environmental factors such as cigarette smoking are known to influence Crohn s disease onset and progression. Active smoking is associated with more aggressive disease, which includes recurrence after surgery and a poor response to medical therapy, Narula explained during a poster presentation at the virtual Advances in Infl

Neeraj narulaMcmaster university medical centerUniversity of ottawaInflammatory bowel diseaseInflammatory bowelநீரஜ் நருலாமக்மாஸ்டர் பல்கலைக்கழகம் மருத்துவ மையம்பல்கலைக்கழகம் ஆஃப் ஆடவாஅழற்சி குடல் நோய்அழற்சி குடல்