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Study reveals how egg cells get so big March 5, 2021MIT Egg cells are by far the largest cells produced by most organisms. In humans, they are several times larger than a typical body cell and about 10,000 times larger than sperm cells. There’s a reason why egg cells, or oocytes, are so big: They need to accumulate enough nutrients to support a growing embryo after fertilization, plus mitochondria to power all of that growth. However, biologists don’t yet understand the full picture of how egg cells become so large. A new study in fruit flies, by a team of MIT biologists and mathematicians, reveals that the process through which the oocyte grows significantly and rapidly before fertilization relies on physical phenomena analogous to the exchange of gases between balloons of different sizes. Specifically, the researchers showed that “nurse cells” surrounding the much larger oocyte dump their contents into the larger cell, just as air flows from a smaller balloon into a lar

Imran alsousFrank masonJonathan jacksonNicolas romeoAdam martinJasmin imran alsousRoberte collins distinguished scholarship fundHarvard universityProceedings of the national academy sciencesJamess mcdonnell foundationVanderbilt university school of medicineNational instituteNational academyVanderbilt university schoolGeneral medical sciencesComplex systems scholar award