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Asymmetric synthesis of aziridine with a new catalyst can help develop novel medicines

 E-Mail IMAGE: Scientists from Japan recently proposed a possible transition state for the reaction between aziridines and oxazolones in presence of a cinchona alkaloid sulfonamide catalyst, producing desirable aziridine-oxazolone compounds with high. view more  Credit: Image courtesy: Shuichi Nakamura from NITech Unless you ve studied chemistry in college, it s unlikely you ve come across the name aziridine. An organic compound with the molecular formula, C2H4NH, aziridines are well-known among medicinal chemists, who make use of the compound to prepare pharmaceutical drugs such as Mitomycin C, a chemotherapeutic agent known for its anti-tumor activity. Specifically, aziridines are what chemists call enantiomers molecules that are mirror images of each other and cannot be superposed on one another. A peculiarity with enantiomers is that the biological activity of one is different from its mirror image and only one of them is desirable for making drugs. Chemists, ther

Shedding Light on the Role of Undesired Impurities in Gallium Nitride Semiconductors

Shedding Light on the Role of Undesired Impurities in Gallium Nitride Semiconductors
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