Credit: UT Southwestern Medical Center
Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, published online today in
Cell Stem Cell, could offer hope for the hundreds of thousands of people worldwide who suffer a spinal cord injury each year.
Cells in some body tissues proliferate after injury, replacing dead or damaged cells as part of healing. However, explains study leader Chun-Li Zhang, Ph.D., professor of molecular biology and a W.W. Caruth, Jr. Scholar in Biomedical Research at UTSW, the spinal cord typically does not generate new neurons after injury - a key roadblock to recovery. Because the spinal cord acts as a signal relay between the brain and the rest of the body, he adds, its inability to self-repair permanently halts communication between these two areas, leading to paralysis, loss of sensation,
E-Mail
IMAGE: This illustration shows the atomic level resolution of the tetracycline antibiotic bound to the EphB1 receptor. view more
Credit: UT Southwestern Medical Center
DALLAS - Feb. 22, 2021 - Three decades-old antibiotics administered together can block a type of pain triggered by nerve damage in an animal model, UT Southwestern researchers report. The finding, published online today in
PNAS, could offer an alternative to opioid-based painkillers, addictive prescription medications that are responsible for an epidemic of abuse in the U.S.
Over 100 million Americans are affected by chronic pain, and a quarter of these experience pain on a daily basis, a burden that costs an estimated $600 billion in lost wages and medical expenses each year. For many of these patients - those with cancer, diabetes, or trauma, for example - their pain is neuropathic, meaning it s caused by damage to pain-sensing nerves.
Biodegradable microcapsules guide neuronal development by delivering nerve growth factor ANI | Updated: Feb 21, 2021 17:36 IST
Moscow [Russia], February 21 (ANI): Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in-vitro experiment. These microcapsules play a critical role in nerve growth factor, a peptide that is necessary for neuron growth.
The findings of the study were published in the journal Pharmaceutics. Many neurodegenerative conditions that can lead to severe disorders are associated with depleted levels of growth factors in the brain - neuropeptides that help neurons grow, proliferate and survive.
Some clinical studies of Alzheimer s and Parkinson s diseases have shown that delivering these growth factors to specific degenerating neurons can have a therapeutic effect.
Hastası için ABD ye gidip, Moyamoya eğitimi aldı, dönüşte ameliyat yaptı haberler.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from haberler.com Daily Mail and Mail on Sunday newspapers.