3D Printing Used to Create Engineered Flat Brain Organoid Scaffolds
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March 17, 2021
An international research team from the Autonomous University of Madrid and the Technical University of Denmark (TUD) reported that it used 3D printing to create scaffolds for engineered flat brain organoids. The scaffolds allowed the brain organoid size to be significantly increased and, after 20 days, self-generated folding was observed, according to the scientists who published their study, “Next generation human brain models: engineered flat brain organoids featuring gyrification,” in
Biofabrication.
“Brain organoids are considered to be a highly promising in vitro model for the study of the human brain and, despite their various shortcomings, have already been used widely in neurobiological studies. Especially for drug screening applications, a highly reproducible protocol with simple tissue culture steps and consistent output, is required,” the investig
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The research, by an international team from the Autonomous University of Madrid and the Technical University of Denmark, used 3D printing to create scaffolds for engineered flat brain organoids. The scaffolds allowed the brain organoid size to be significantly increased and after 20 days, self-generated folding was observed. Their results are published in the IOP Publishing journal
The work aims to address several of the shortcomings of existing brain organoids. One of the lead authors, Theresa Rothenbücher, said: The lack of vascularization leads to diffusion limitations for nutrients and oxygen, resulting in a necrotic tissue core for organoids larger than approximately 500 μm. In an attempt to solve this problem, brain organoids have been vascularized. While including endothelial cells in the culture system increases the complexity of the model, the generated vessel structures show no functionality (blood flow) in vitro. We are able to circumvent this issue by apply
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University of Tasmania
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