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There s a new test for cancer risks from a longtime Jewish genetic screening program

May 20, 2021 9:54 am It was only after Abby Match was diagnosed with an aggressive form of breast cancer that she learned she was a carrier of a mutation in her BRCA1 gene associated with a significantly elevated risk for developing breast cancer at a young age. (Courtesy of Match) Advertisement After discovering a suspicious lump in her breast one day while in the shower, Abby Match was diagnosed in August with an aggressive form of breast cancer. She subsequently underwent a bilateral mastectomy, a hysterectomy, chemotherapy and radiation. It was only after she discovered she was sick that Match, 35, learned she was a carrier of a mutation in her BRCA1 gene associated with a significantly elevated risk for developing breast cancer at a young age, and also for ovarian and other cancers. One in 40 Ashkenazi Jews have a BRCA mutation, which is 10 times higher than in the general population.

JScreen Is Making Cancer Genetic Testing Accessible

JScreen Is Making Cancer Genetic Testing Accessible Ashkenazi men and women face a 1-in-40 risk of carrying mutations in the BRCA1 and BRCA2 genes (genes linked to breast, ovarian, prostate, pancreatic and melanoma cancers) more than 10 times the risk in the general population. JScreen, a national public health initiative based at Emory University, Atlanta, has announced what could be a major breakthrough: a program that offers at-home testing for more than 60 cancer susceptibility genes linked to certain hereditary risks. “This type of testing is important because it alerts people to their risks before they get cancer,” explained Jane Lowe Meisel, MD, an associate professor at Emory’s School of Medicine. “They can then take action to help prevent cancer altogether or to detect it at an early, treatable stage.”

Black women with breast cancer show high comorbidity rates

December 10, 2020 Black women had high rates of health conditions linked to worse breast cancer outcomes in a study published on December 7 in Cancer. These trends could be contributing to worse breast cancer outcomes for Black women despite years of better treatment options and widespread screening mammography. The retrospective study, led by Kirsten Nyrop, PhD, looked at differences among 548 Black and white women diagnosed with early-stage breast cancer. Black patients had higher rates of hypertension, high cholesterol, and diabetes at diagnosis, even after the authors adjusted for age and body mass index (BMI) score. Both obesity and HR+ breast cancers have been rising in the U.S. for decades. While new treatments and widespread screening mammography have resulted in better breast cancer outcomes overall, Black women are still more likely to die from breast cancer than white women.

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