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Views: Visits 9 The results of ground-breaking research conducted by Malaria Consortium show that low previous malaria exposure is associated with more severe symptoms of COVID-19 and adverse outcomes compared with high exposure to malaria. Patients co-infected with malaria and COVID-19 tend to have a higher frequency of confusion and vomiting but co-infection was not detrimental to a patient’s outcome. The results were recently published in preprint in The Lancet. Malaria causes significant morbidity and mortality with an estimated 229 million cases and 409,000 deaths reported globally in 2019 alone, over 90 percent of these in sub-Saharan Africa. The potential implications of any clinical interactions between COVID-19 and malaria infection is therefore a major public health concern in Africa, where the chances of co-infection is relatively high. The objective of the study was to better characterise COVID-19 cases in a high malaria burden setting and to determine