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 E-Mail Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight. Reduced expression of mINDY, which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target.

Baden wubergAndreas birkenfeldAndreasl birkenfeldDepartment of internal medicineGerman diabetes centerGerman research centerEnvironmental healthDiabetes researchGerman institute of human nutrition difNephrology of the university hospitalGerman centerHelmholtz center munichUniversity hospitalPaul langerhans institute dresden of helmholtz zentrumInstitute of diabetes researchCarl gustav carus university hospital