E-Mail
Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the
Journal of Clinical Investigation (JCI) insight. Reduced expression of mINDY, which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target.
E-Mail
IMAGE: The researchers examined data from study participants of the EPIC-Potsdam study who developed type 2 diabetes during the follow-up of the study. Thus, an increase in risk for microvascular complications. view more
Credit: Source: DIfE
Successful weight loss is considered to be an integral part of the therapy for type 2 diabetes. Nevertheless, studies keep appearing that question the importance of losing weight. However, new data from a large-scale observational study carried out at DIfE in cooperation with the German Center for Diabetes Research (DZD) support the current recommendations of physicians. The findings, published in the journal
Diabetologia, suggest that obesity and weight gain can lead to vascular disorders, the leading cause of disease and death for people with type 2 diabetes.
E-Mail
IMAGE: Obesity and cardiometabolic diseases do not only trigger a more severe course of COVID-19, the SARS-CoV-2 infection could promote the development of these conditions. view more
Credit: Norbert Stefan
In a
Nature Reviews Endocrinology article authors from the German Center for Diabetes Research (DZD) highlight the interconnection of obesity and impaired metabolic health with the severity of COVID-19. First, they provide information about the independent relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19. Then they discuss mechanisms for a complicated course of COVID-19 and how this disease may impact on the global obesity and cardiometabolic pandemics. Finally, they provide recommendations for prevention and treatment in clinical practice and in the public health sector to combat these global pandemics.