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Covid-19, Ireland and China: Why aren t we using the Sinovac and Sinopharm vaccines?

Covid-19, Ireland and China: Why aren t we using the Sinovac and Sinopharm vaccines? Priscilla Lynch looks at Chinese-Irish relations during the Covid-19 pandemic. By Priscilla Lynch Sunday 6 Jun 2021, 12:05 AM 1 hour ago 4,359 Views 4 Comments WHY ISN’T IRELAND, or the EU, using the Chinese vaccines yet? Will they ever be used here? It’s possible but unlikely anytime soon. While China has developed and approved a number of Covid-19 vaccines, none are yet licensed in Europe. A number of African, Latin American and Asian countries have chosen to approve and use the Vero Cell vaccine by the Beijing-based pharmaceutical company Sinovac and the Sinopharm vaccine, produced by Beijing Bio-Institute of Biological Products Co Ltd, subsidiary of China National Biotec Group (CNBG)

Response mechanism of ICB among patients with breast cancer and novel approach to predicting therapeutic efficacy

H1 and T FH cells, lead to clonal expansion and are likely to contribute to ICB response. In pre-treatment biopsies, the relative frequency of immunoregulatory dendritic cells (PD-L1 +), specific macrophage phenotypes (CCR2 + or MMP9 +) and cancer cells exhibiting major histocompatibility complex class I/II expression correlated positively with T cell expansion. Conversely, undifferentiated pre-effector/memory T cells (TCF7 +, GZMK +, C3 +) were inversely correlated with T cell expansion. These data identify various immunophenotypes and associated gene sets that are positively or negatively correlated with T cell expansion following anti-PD1 treatment. Immune microenvironments and biomarkers associated with immunotherapy response “This study thus provides insights into potential predictive biomarkers of post-ICB clinical benefit,” said QIAN Junbin, adding that the research paradigm is expected to be applied to the study of other tumors and even other diseases.

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