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Six KU Leuven researchers receive ERC Advanced Grant
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Montis Biosciences Awarded VLAIO Grant to Expand its Pipeline of Novel Immune-Oncology Therapeutics
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H1 and T
FH cells, lead to clonal expansion and are likely to contribute to ICB response. In pre-treatment biopsies, the relative frequency of immunoregulatory dendritic cells (PD-L1
+), specific macrophage phenotypes (CCR2
+ or MMP9
+) and cancer cells exhibiting major histocompatibility complex class I/II expression correlated positively with T cell expansion. Conversely, undifferentiated pre-effector/memory T cells (TCF7
+, GZMK
+, C3
+) were inversely correlated with T cell expansion. These data identify various immunophenotypes and associated gene sets that are positively or negatively correlated with T cell expansion following anti-PD1 treatment.
Immune microenvironments and biomarkers associated with immunotherapy response
“This study thus provides insights into potential predictive biomarkers of post-ICB clinical benefit,” said QIAN Junbin, adding that the research paradigm is expected to be applied to the study of other tumors and even other diseases.